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Aggression subtyping for improved insight and treatment innovation in psychiatric disorders

Aggression subtyping for improved insight and treatment innovation in psychiatric disorders

Objective

Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental subtypes, we investigate the aetiology of maladaptive aggression in paediatric conduct disorders most strongly predisposing to pathological aggression, ADHD and conduct disorder, and in the general population. We employ highly innovative approaches in humans and animal models and maximize the output from the project by optimally balancing the use of large, existing data sets with new data acquisition. Through this, we build a knowledge chain from molecule to behaviour, investigating known and novel genes, gene-networks and their epigenetic interactions, and mapping their mode of action from the molecular via the cellular to the brain-circuit level. This is accompanied by highly powered analyses of the neural substrates of the aggression subtypes.
Based on innovative bioinformatic multimodal data integration, our interdisciplinary research will lead to novel, accurate algorithms for reliable aggression prediction, which will be validated in existing longitudinal studies in children and tested for their predictive value in adult outcome. In addition to this approach towards prevention, we test promising non-pharmacological biofeedback for personalised treatment and prevention of overt aggression. For the identification of novel pharmacological compounds in aggression treatment, we introduce a new animal model, the zebrafish.
The Aggressotype consortium is based on successful existing collaborations. It includes experts in childhood and adult psychiatry and research-intensive SMEs ensuring maximal dissemination, clinical implementation and business development opportunities.
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Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT

Address

Geert Grooteplein Noord 9
6525 Ez Nijmegen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 777 771,98

Participants (25)

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KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 202 160,40

UNIVERSITAT DE BARCELONA

Spain

EU Contribution

€ 61 500

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA

Spain

EU Contribution

€ 80 000

UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT

Germany

EU Contribution

€ 124 981,56

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

Germany

EU Contribution

€ 478 661,60

UNIVERSITETET I BERGEN

Norway

EU Contribution

€ 100 000

THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

United States

EU Contribution

€ 140 000

TARTU ULIKOOL

Estonia

EU Contribution

€ 200 000

UNIVERSITY OF LEICESTER

United Kingdom

EU Contribution

€ 255 000

UNIVERSITEIT MAASTRICHT

Netherlands

EU Contribution

€ 475 000

ISLENSK ERFDAGREINING EHF

Iceland

EU Contribution

€ 9 792

GENALICE BV

Netherlands

EU Contribution

€ 200 000

GENOWAY S.A.

France

EU Contribution

€ 100 000

VIEW POINT SA

France

EU Contribution

€ 250 000

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 210 000

Concentris Research Management GmbH

Germany

EU Contribution

€ 360 000

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 45 000

UNIVERSITY OF DUNDEE

United Kingdom

EU Contribution

€ 36 276,02

UNIVERSITAET ULM

Germany

EU Contribution

€ 45 000

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

EU Contribution

€ 45 000

SERVICIO MADRILENO DE SALUD

Spain

EU Contribution

€ 47 160

OSPEDALE PEDIATRICO BAMBINO GESU

Italy

EU Contribution

€ 45 000

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Germany

EU Contribution

€ 279 018,44

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 216 357

STATENS SERUM INSTITUT

Denmark

EU Contribution

€ 216 321

Project information

Grant agreement ID: 602805

Status

Closed project

  • Start date

    1 November 2013

  • End date

    31 October 2018

Funded under:

FP7-HEALTH

  • Overall budget:

    € 7 863 780,82

  • EU contribution

    € 6 000 000

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands