Objetivo How do naïve cells in a developing tissue know when to divide and when to stop dividing when the tissue reaches its final size? How do they acquire information about their position to generate morphological patterns? Morphogen gradients have been shown to control pattern formation and growth. While the mechanisms of patterning are starting to be understood, the mechanism of growth by morphogens is not yet deciphered.In a few recent reports, we studied the biophysics and cell biology of the Dpp morphogen gradient during growth of Drosophila imaginal discs. We showed that the Dpp gradient expands and scales with the size of the growing tissue. Scaling occurs by the regulation of Dpp lysosomal degradation as a function of tissue size. We also showed that any cell in the developing tissue (no matter the developmental stage, the position of the cell in the gradient or the imaginal disc considered) divides when it sees an increase of Dpp signaling by α=50% from the beginning of the cell cycle. The proliferation rate g of cells is proportional to the relative time derivative of signaling (i.e. C ̇/C, the time derivative of Dpp signaling level C ̇ (Cdot) normalized to the actual signaling level C): g=(ln2/α)*(Cdot/C). We will study the molecular cell-biology of growth control by morphogens in an interdisciplinary combination of physical theory, biophysics and biochemistry in the context of development. Ámbito científico natural sciencesbiological sciencesbiochemistrynatural sciencesbiological sciencescell biologynatural sciencesbiological sciencesbiophysics Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-AG-LS3 - ERC Advanced Grant - Cellular and Developmental Biology Convocatoria de propuestas ERC-2013-ADG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-AG - ERC Advanced Grant Institución de acogida UNIVERSITE DE GENEVE Aportación de la UE € 2 389 109,00 Dirección RUE DU GENERAL DUFOUR 24 1211 Geneve Suiza Ver en el mapa Región Schweiz/Suisse/Svizzera Région lémanique Genève Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Alex Waehry (Dr.) Investigador principal Marcos Antonio Gonzalez Gaitan (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITE DE GENEVE Suiza Aportación de la UE € 2 389 109,00 Dirección RUE DU GENERAL DUFOUR 24 1211 Geneve Ver en el mapa Región Schweiz/Suisse/Svizzera Région lémanique Genève Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Alex Waehry (Dr.) Investigador principal Marcos Antonio Gonzalez Gaitan (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Alemania Aportación de la UE € 110 400,00 Dirección HOFGARTENSTRASSE 8 80539 Munchen Ver en el mapa Región Bayern Oberbayern München, Kreisfreie Stadt Tipo de actividad Research Organisations Contacto administrativo Ilona Auguszt (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos