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Multidisciplinary Approaches to Translational Research In Conduct Syndromes

Objetivo

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypothesis that reactive and instrumental aggression result from aberrant autonomic reactivity coupled to the differential impairment of three basic neural functions: 1) regulation of control mechanisms of aggression, 2) emotional value rating of others, and 3) empathy and moral decision making. MATRICS will employ the same psychological tasks assessing 1), 2) and 3) in animal aggression models and human CD samples concurrent with the assessment of neural, neurochemical, (epi)-genetic and autonomic nervous system markers. These data will be integrated with matching expression profiling from neurons derived from CD IPSCs. MATRICS also examines how environmental risks, whether or not they interact with genetic factors, are translated in epigenetic and neural changes. MATRICS will data-mine existing large integrated imaging-genetics cohorts (NeuroIMAGE; IMAGEN) and prospective cohorts (TRAILS; ALSPAC) with follow-up into adulthood and the (epi)genetic profiling of the PERS CD cohort, and collect a large new CD cohort and controls for collection of MRI, (epi)-genetic, biochemical and environmental measures. Bayesian machine learning tools will integrate multi-source and multi-level data, and generate predictive algorithms of persistent aggression into adulthood. MATRICS will identify new potentially ‘druggable’ targets, develop novel animal models and conduct pilot medication and neuro/biofeedback studies in high-risk and CD patients. MATRICS builds on existing fruitful EU collaborations which maximises feasibility and successful output.

Convocatoria de propuestas

FP7-HEALTH-2013-INNOVATION-1
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Coordinador

STICHTING RADBOUD UNIVERSITEIT
Dirección
Houtlaan 4
6525 XZ Nijmegen
Países Bajos
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 256 728,85
Contacto administrativo
Maarten Van Langen (Mr.)

Participantes (19)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Suiza
Aportación de la UE
€ 270 740
Dirección
Batiment Ce 3316 Station 1
1015 Lausanne
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Carmen Sandi (Prof.)
ISTITUTO SUPERIORE DI SANITA
Italia
Aportación de la UE
€ 267 900
Dirección
Viale Regina Elena 299
00161 Roma
Tipo de actividad
Research Organisations
Contacto administrativo
Rosa Maria Martoccia (Dr.)
GENOWAY
Francia
Aportación de la UE
€ 65 630
Dirección
31 Rue Saint Jean De Dieu Technopark 2
69007 Lyon
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Gaelle Lebel (Ms.)
KING'S COLLEGE LONDON
United Kingdom
Aportación de la UE
€ 886 928
Dirección
Strand
WC2R 2LS London
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Paul Labbett (Mr.)
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Alemania
Aportación de la UE
€ 238 675
Dirección
Square J 5
68159 Mannheim
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Tobias Banaschewski (Prof.)
UNIVERSITY OF DUNDEE

La participación finalizó

United Kingdom
Aportación de la UE
€ 15 445,76
Dirección
Nethergate
DD1 4HN Dundee
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Zoe Kidd (Mrs.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Países Bajos
Aportación de la UE
€ 184 288
Dirección
Hanzeplein 1
9713 GZ Groningen
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Johanna M. Van Apeldoorn (Ms.)
THE UNIVERSITY OF EXETER
United Kingdom
Aportación de la UE
€ 300 000
Dirección
The Queen's Drive Northcote House
EX4 4QJ Exeter
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Gaynor Hughes (Ms.)
UNIVERSITA DEGLI STUDI DI CAGLIARI
Italia
Aportación de la UE
€ 127 240
Dirección
Via Universita 40
09124 Cagliari
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Alessandro Zuddas (Prof.)
neuroConn GmbH
Alemania
Aportación de la UE
€ 98 700
Dirección
Albert-einstein-strasse 3
98693 Ilmenau
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Ralf Kersten (Prof.)
UNIVERSITAET ULM
Alemania
Aportación de la UE
€ 54 508
Dirección
Helmholtzstrasse 16
89081 Ulm
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Frank Gleixner (Mr.)
CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER
Francia
Aportación de la UE
€ 49 200
Dirección
Avenue Du Doyen Gaston Giraud 191
34000 Montpellier
Tipo de actividad
Research Organisations
Contacto administrativo
Valérie Handweiler (Mrs.)
PHENOSYS GMBH
Alemania
Aportación de la UE
€ 60 000
Dirección
Schumannstrasse 18
10117 Berlin
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
York Winter (Prof.)
CONCENTRIS RESEARCH MANAGEMENT GMBH
Alemania
Aportación de la UE
€ 313 700
Dirección
Ludwigstr. 4
82256 Furstenfeldbruck
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Ameli Schwalber (Dr.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
España
Aportación de la UE
€ 18 838,09
Dirección
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Tipo de actividad
Other
Contacto administrativo
Pastora Martinez Samper (Dr.)
SERVICIO MADRILENO DE SALUD
España
Aportación de la UE
€ 17 869,30
Dirección
Plaza Carlos Trias Bertran 7
28020 Madrid
Tipo de actividad
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contacto administrativo
Bardinet Thierry (Mr.)
CERTAIN INDEXES LIMITED
United Kingdom
Aportación de la UE
€ 167 580
Dirección
Park Road 4 Sileby
LE12 7TJ Loughborough
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Greg Prescott (Mr.)
DRUG TARGET ID BV
Países Bajos
Aportación de la UE
€ 50 000
Dirección
Toernooiveld 200
6525 EC Nijmegen
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Geert Poelmans (Dr.)
Fondazione Stella Maris
Italia
Aportación de la UE
€ 56 029
Dirección
Viale Del Tirreno 331
56118 Pisa
Tipo de actividad
Research Organisations
Contacto administrativo
Barbara Collina Grenci (Dr.)