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Mapping the Deprived Visual System: Cracking function for prediction

Objective

One of the most striking demonstrations of experience-dependent plasticity comes from studies of blind individuals showing that the occipital cortex (traditionally considered as purely visual) massively changes its functional tuning to support the processing of non-visual inputs. These mechanisms of crossmodal plasticity, classically considered compensatory, inevitably raise crucial challenges for sight-restoration. The neglected relation between crossmodal plasticity and sight-recovery will represent the testing ground of MADVIS in order to gain important novel insights on how specific brain regions become, stay and change their functional tuning toward the processing of specific stimuli. The main goal of MADVIS is therefore to make a breakthrough on two fronts: (1) understanding how visual deprivation at different sensitive periods in development affects the functional organization and connectivity of the occipital cortex; and (2) use the fundamental knowledge derived from (1) to test and predict the outcome of sight restoration. Using a pioneering interdisciplinary approach that crosses the boundaries between cognitive neurosciences and ophthalmology, MADVIS will have a large impact on our understanding of how experience at different sensitive periods shapes the response properties of specific brain regions. Finally, in its attempt to fill the existing gap between crossmodal reorganization and sight restoration, MADVIS will eventually pave the way for a new generation of predictive surveys prior to sensory restoration.

Call for proposal

ERC-2013-StG
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Host institution

UNIVERSITE CATHOLIQUE DE LOUVAIN
Address
Place De L Universite 1
1348 Louvain La Neuve
Belgium

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Activity type
Higher or Secondary Education Establishments
Principal investigator
Olivier Marie-Claire Michel Ghislain Collignon (Dr.)
Administrative Contact
Anne Bovy (Mrs.)
EU contribution
€ 571 697,47

Beneficiaries (2)

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
EU contribution
€ 571 697,47
Address
Place De L Universite 1
1348 Louvain La Neuve

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Activity type
Higher or Secondary Education Establishments
Principal investigator
Olivier Marie-Claire Michel Ghislain Collignon (Dr.)
Administrative Contact
Anne Bovy (Mrs.)
UNIVERSITA DEGLI STUDI DI TRENTO
Italy
EU contribution
€ 917 289,53
Address
Via Calepina 14
38122 Trento

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vanessa Ravagni (Mrs.)