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DOLORisk: Understanding risk factors and determinants for neuropathic pain

Objective

Neuropathic pain (NP) is common (population prevalence of 7-8%) and will present a rising health burden in the future. NP results in significant morbidity, reduces quality of life and has a major deleterious impact on health in aging. The reason why some subjects develop neuropathic pain and others do not following the same injury is not known. The exact nature of risk factors for NP and their interaction are currently poorly understood and will be the focus of this project. We will establish an international consortium of leading researchers in the field of NP (DOLORisk consortium) involving members of established academic European consortia studying pain/genomics and neuropathy as well as the SMEs Neuroscience Technologies and Mentis Cura. The project will be highly translational and the starting point will be the study of patients with NP or at risk of developing NP.
Specific objectives will be to:
1) Identify the influence of demographic factors, environmental/societal and clinical factors on the risk of developing and maintenance of NP
2) To apply modern genomics to validate (using a targeted approach) and find novel (using genome wide association) genetic risk factors for NP.
3) Use tissue samples and patient derived cells from Biobanks to validate of molecular pathways contributing to chronic pain in patients.
4) To determine if patient stratification using physiological (sensory profile, endogenous analgesic mechanisms and nerve excitability) and psychological factors can predict NP risk and progression.
5) Development of a risk model/algorithm for (severe) NP, combining measurable genetic and environmental factors.

Our aim is to understand pain pathophysiology in terms of risk factors and protective mechanisms ranging from molecular pathways to societal impacts. The desired impact is to provide a firm platform to improve diagnosis and stratify patients according to risk profile, employ preventive strategies and ultimately develop novel therapeutics.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2014-two-stage

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution
€ 1 343 090,00
Address
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (11)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 436 764,00
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITY OF DUNDEE
United Kingdom
Net EU contribution
€ 586 880,00
Address
Nethergate
DD1 4HN Dundee

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Region
Eastern Scotland Angus and Dundee City
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
MENTIS CURA EHF
Iceland
Net EU contribution
€ 177 500,00
Address
Laugavegi 176
105 Reykjavik

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ísland Ísland Höfuðborgarsvæði
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 538 348,75
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
Net EU contribution
€ 411 250,00
Address
Olshausenstrasse 40
24118 Kiel

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Region
Schleswig-Holstein Schleswig-Holstein Kiel, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
LUNDS UNIVERSITET
Sweden
Net EU contribution
€ 686 250,00
Address
Paradisgatan 5c
22100 Lund

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Net EU contribution
€ 406 250,00
Address
Senate Building Technion City
32000 Haifa

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITEIT GENT
Belgium
Net EU contribution
€ 386 282,50
Address
Sint Pietersnieuwstraat 25
9000 Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
NEUROSCIENCE TECHNOLOGIES SLP
Spain
Net EU contribution
€ 466 588,00
Address
Baldiri Reixac 15-21
08028 Barcelona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
AARHUS UNIVERSITET
Denmark
Net EU contribution
€ 403 576,25
Address
Nordre Ringgade 1
8000 Aarhus C

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Region
Danmark Midtjylland Østjylland
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
AARHUS UNIVERSITETSHOSPITAL
Denmark
Net EU contribution
€ 138 440,00
Address
Palle Juul-jensens Boulevard 99
8200 Aarhus

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Region
Danmark Midtjylland Østjylland
Activity type
Research Organisations
Other funding
€ 0,00