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Female cancer prediction using cervical omics to individualise screening and prevention

Objective

While prevention of most female specific cancers (ovarian, breast, endometrial) has not progressed substantially in recent years, significant progress has been made with cervical cancer due to accessibility of the cell of origin (cervical smear) and availability of a test for the causal agent (human papilloma virus); together these enable identification of high risk individuals and interventions to prevent infection or halt progression to invasive cancer.
Our consortium has developed an exciting opportunity to utilise clinically abundant cervical cells in tandem with a multi-omics enabled (genome, epigenome, metagenome) analysis pipeline to understand an individual’s risk of developing a female specific cancer and to direct a personalised screening and prevention strategy. Cervical cells – currently collected within cervical cancer screening – provide an ideal window into other female specific cancers because they are (i) an excellent non-invasive source of high quality DNA, (ii) provide a readout for environmental exposure, (iii) are part of the Müllerian tract and (iv) are hormone sensitive, recording (via the epigenome) various hormonal conditions over a lifetime that trigger cancer development. The FORECEE project is aligned with the novel concept of “P4 Medicine” (predictive, preventive, personalized, and participatory): it aims to translate the risk prediction tool’s output into personalised recommendations for screening and prevention of female cancers.
Our consortium comprises a multi-disciplinary team of experts in clinical oncology, risk-benefit communication, omics technologies, decision analysis, health economics and public health. We will examine the effectiveness of the proposed cervical cell omics analysis method and investigate the legal, social, ethical and behavioural issues related to implementation of the risk prediction tool, through direct interaction with stakeholder groups, to ensure its rapid translation into clinical practice across Europe.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /social sciences/economics and business/economics
  • /social sciences/economics and business
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /medical and health sciences/clinical medicine/oncology
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITY COLLEGE LONDON
Address
Gower Street
WC1E 6BT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 890 699,11

Participants (13)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 711 182,50
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 426 520
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments
HELSE BERGEN HF*HAUKELAND UNIVERSITY HOSPITAL
Norway
EU contribution
€ 269 697,50
Address
Jonas Lies Vei 65
5021 Bergen
Activity type
Higher or Secondary Education Establishments
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
EU contribution
€ 160 500
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY HOSPITALS SOUTHAMPTON NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 78 926,50
Address
Tremona Road
SO16 6YD Southampton
Activity type
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 299 200
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 210 077,50
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE

Participation ended

United Kingdom
EU contribution
€ 0
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 557 866
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
ONCOTYROL-CENTER FOR PERSONALIZED CANCER MEDICINE GMBH
Austria
EU contribution
€ 498 440
Address
Karl Kapferer Strasse 5/3
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 248 987,50
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
EURAM LIMITED

Participation ended

United Kingdom
EU contribution
€ 83 679,64
Address
Lucy Tower Street Tower House
LN1 1XW Lincoln
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Eurofins Genomics Europe Sequencing GmbH
Germany
EU contribution
€ 558 970
Address
Jakob Stadler Platz 7
78467 Konstanz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)