CORDIS
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Integrating Epidemiology and Experimental Biology to Improve Risk Assessment of Exposure to Mixtures of Endocrine Disruptive Compounds

Objective

A large body of evidence supports associations between exposure to anthropogenic chemicals and endocrine disruptive effects, leading to disorders in humans and wildlife. Based on the scientific documentation it is beyond doubt that endocrine disrupting chemicals (EDCs) are of concern and need to be handled according to the risks they pose, as single chemicals or as mixtures. To develop chemical risk assessment to respond to these concerns, there is an urgent need to improve our understanding of the mechanisms and health effects of EDCs, in particular in mixtures. This will require selection, refinement and development of tools for assessment of EDC mixtures to bring current risk assessment procedures to a level where they can support risk management. This project is designed to promote the use of safe chemicals for the next generation. EDC-MixRisk aims to meet the societal need for improved decision-making regarding human exposure risks to mixtures of EDCs. EDC-MixRisk will determine risks for multiple adverse health outcomes based on molecular mechanisms involved after early life exposure to EDC mixtures. The task is approached through interdisciplinary cooperation between experts in epidemiology, experimental toxicology and molecular biology, and risk assessment. The value of this combined research effort is: i) Identification of EDC mixtures that are associated with multiple adverse health outcomes in three health domains (growth and metabolism, neurodevelopment and sexual development) in epidemiology; ii) Identification of molecular mechanisms and pathways underlying the associations between exposure and adverse health outcomes by the use and development of state-of-the-art experimental models and iii) Development of a transparent and systematic framework in risk assessment for integrating epidemiological and experimental research to facilitate the assessment of risk and societal impact, thus promoting better risk management for EDCs and their mixtures.
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Coordinator

KAROLINSKA INSTITUTET

Address

Nobels Vag 5
17177 Stockholm

Sweden

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 089 181,25

Participants (12)

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KARLSTADS UNIVERSITET

Sweden

EU Contribution

€ 1 194 481,25

GOETEBORGS UNIVERSITET

Sweden

EU Contribution

€ 316 750

LUNDS UNIVERSITET

Sweden

EU Contribution

€ 585 000

STOCKHOLMS UNIVERSITET

Sweden

EU Contribution

€ 450 061,25

UPPSALA UNIVERSITET

Sweden

EU Contribution

€ 418 532,50

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 428 436,25

UNIVERSITAET LEIPZIG

Germany

EU Contribution

€ 62 500

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON

Greece

EU Contribution

€ 321 250

TERVEYDEN JA HYVINVOINNIN LAITOS

Finland

EU Contribution

€ 350 537,50

ISTITUTO EUROPEO DI ONCOLOGIA SRL

Italy

EU Contribution

€ 489 000

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

United States

EU Contribution

€ 265 570

OREBRO UNIVERSITY

Sweden

EU Contribution

€ 252 030

Project information

Grant agreement ID: 634880

Status

Closed project

  • Start date

    1 May 2015

  • End date

    30 April 2019

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 6 223 330

  • EU contribution

    € 6 223 330

Coordinated by:

KAROLINSKA INSTITUTET

Sweden