Objective
Oxygen functionalities are key functional groups in many of today’s chemicals and materials. The efficient introduction of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but were so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> €1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency.
In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications. ROBOX will demonstrate 11 target reactions on large scale for these markets in order to prepare them for scale up to commercial-scale plants.
ROBOX is industry-driven with 2 major industrial players and 6 SME’s. It will assess the potential of technologies applied to become platform technologies technologies (multi-parameter screening systems, computational methodologies, “plug bug” expression systems) for broad replication throughout the chemical industry. The markets addressed within ROBOX represent a joint volume of over 6.000 ktons/year. The introduction of bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).
Fields of science
- engineering and technologyenvironmental engineeringwaste managementwaste treatment processesrecycling
- natural scienceschemical sciencesorganic chemistryalcohols
- natural scienceschemical sciencescatalysisbiocatalysis
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
- natural sciencescomputer and information sciencesartificial intelligencecomputational intelligence
Programme(s)
Funding Scheme
IA - Innovation actionCoordinator
9712CP Groningen
Netherlands
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Participants (24)
1214 Vernier
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2650 Edegem
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
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6709 PA Wageningen
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
04103 Leipzig
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
40789 Monheim
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
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471 27 STRAZ POD RALSKEM
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
8010 Graz
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
8010 Graz
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6167 RD Geleen
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Participation ended
6167 RD Geleen
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
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2613 AX Delft
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
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6411 TE Heerlen
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27100 Pavia
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52062 Aachen
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M13 9PL Manchester
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2800 Kongens Lyngby
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Participation ended
80686 Munchen
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08193 Cerdanyola Del Valles
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8092 Zuerich
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6200 MD Maastricht
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2289 DC Rijswijk
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
1930 Zaventem
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
2342 BH OEGSTGEEST
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6167 RD Geleen
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.