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Expanding the industrial use of Robust Oxidative Biocatalysts for the conversion and production of alcohols (ROBOX)

Objective

Oxygen functionalities are key functional groups in many of today’s chemicals and materials. The efficient introduction of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but were so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> €1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency.

In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications. ROBOX will demonstrate 11 target reactions on large scale for these markets in order to prepare them for scale up to commercial-scale plants.

ROBOX is industry-driven with 2 major industrial players and 6 SME’s. It will assess the potential of technologies applied to become platform technologies technologies (multi-parameter screening systems, computational methodologies, “plug bug” expression systems) for broad replication throughout the chemical industry. The markets addressed within ROBOX represent a joint volume of over 6.000 ktons/year. The introduction of bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).

Field of science

  • /natural sciences/chemical sciences/electrochemistry/electrolysis
  • /natural sciences/chemical sciences/organic chemistry/alcohols
  • /social sciences/economics and business/economics/bioeconomy
  • /social sciences/economics and business/economics/production economics
  • /medical and health sciences/health sciences/nutrition
  • /engineering and technology/industrial biotechnology/bioprocessing technologies/biocatalysis
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes
  • /natural sciences/computer and information sciences/artificial intelligence/computational intelligence
  • /natural sciences/chemical sciences/organic chemistry/ketones
  • /social sciences/economics and business/business and management/commerce

Call for proposal

H2020-LEIT-BIO-2014-1
See other projects for this call

Funding Scheme

IA - Innovation action

Coordinator

RIJKSUNIVERSITEIT GRONINGEN
Address
Broerstraat 5
9712CP Groningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 062 896,25

Participants (20)

GIVAUDAN SUISSE SA
Switzerland
EU contribution
€ 0
Address
Chemin De La Parfumerie 5
1214 Vernier
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CHEMSTREAM BVBA
Belgium
EU contribution
€ 298 812,50
Address
Drie Eikenstraat 661
2650 Edegem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DYADIC NEDERLAND BV

Participation ended

Netherlands
EU contribution
€ 89 577,52
Address
Nieuwe Kanaal 7 S
6709 PA Wageningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
C-LECTA GMBH
Germany
EU contribution
€ 274 952,13
Address
Perlickstrasse 5
04103 Leipzig
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EVOXX TECHNOLOGIES GMBH
Germany
EU contribution
€ 312 025
Address
Alfred Nobel Strasse 10
40789 Monheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LentiKat's a.s.

Participation ended

Czechia
EU contribution
€ 55 810,18
Address
Pod Vinici 83
471 27 Straz Pod Ralskem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ACIB GMBH
Austria
EU contribution
€ 282 278,75
Address
Krenngasse 37/2
8010 Graz
Activity type
Research Organisations
TECHNISCHE UNIVERSITAET GRAZ
Austria
EU contribution
€ 675 415
Address
Rechbauerstrasse 12
8010 Graz
Activity type
Higher or Secondary Education Establishments
DSM MATERIALS SCIENCE CENTER BV

Participation ended

Netherlands
EU contribution
€ 762 832,88
Address
Urmonderbaan 22
6167 RD Geleen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
EU contribution
€ 447 205
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
Germany
EU contribution
€ 741 418,75
Address
Templergraben 55
52062 Aachen
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 472 391,01
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 705 258,75
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Participation ended

Germany
EU contribution
€ 211 232,10
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
UNIVERSIDAD AUTONOMA DE BARCELONA
Spain
EU contribution
€ 489 782,50
Address
Calle Campus Universitario Sn Cerdanyola V
08290 Cerdanyola Del Valles
Activity type
Higher or Secondary Education Establishments
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 0
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 458 296,25
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
PNO CONSULTANTS BV
Netherlands
EU contribution
€ 97 370
Address
Laan Van Zuid Hoorn 15
2289 DC Rijswijk
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GENENCOR INTERNATIONAL BV
Netherlands
EU contribution
€ 265 759,10
Address
Archimedesweg 30
2333 CN Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INNOSYN BV
Netherlands
EU contribution
€ 478 362,50
Address
Urmonderbaan 22
6167 RD Geleen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)