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Molecular Subtype Specific Stem Cell Dynamics in Developing and Established Colorectal Cancers

Publications

Cancer stem cells: here, there, and everywhere

Author(s): Sophie C. Lodestijn, Kristiaan J. Lenos, Daniël M. Miedema, Maarten F. Bijlsma, Louis Vermeulen
Published in: Molecular & Cellular Oncology, Issue 6/1, 2019, Page(s) 1540235, ISSN 2372-3556
Publisher: Frontiers
DOI: 10.1080/23723556.2018.1540235

Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development

Author(s): Ronja S. Adam, Sanne M. van Neerven, Cayetano Pleguezuelos-Manzano, Salvatore Simmini, Nicolas Léveillé, Nina E. de Groot, Andrew N. Holding, Florian Markowetz, Louis Vermeulen
Published in: Cancer Cell International, Issue 20/1, 2020, ISSN 1475-2867
Publisher: BioMed Central
DOI: 10.1186/s12935-020-01661-6

A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype

Author(s): E Fessler, M Jansen, F De Sousa E Melo, L Zhao, P R Prasetyanti, H Rodermond, R Kandimalla, J F Linnekamp, M Franitza, S R van Hooff, J H de Jong, S C Oppeneer, C J M van Noesel, E Dekker, G Stassi, X Wang, J P Medema, L Vermeulen
Published in: Oncogene, Issue 35/46, 2016, Page(s) 6026-6037, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/onc.2016.134

Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry

Author(s): Anne Trinh, Kari Trumpi, Felipe De Sousa E Melo, Xin Wang, Joan H. de Jong, Evelyn Fessler, Peter J.K. Kuppen, Marlies S. Reimers, Marloes Swets, Miriam Koopman, Iris D. Nagtegaal, Marnix Jansen, Gerrit K.J. Hooijer, George J.A. Offerhaus, Onno Kranenburg, Cornelis J. Punt, Jan Paul Medema, Florian Markowetz, Louis Vermeulen
Published in: Clinical Cancer Research, Issue 23/2, 2017, Page(s) 387-398, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-16-0680

Polycomb complex PRC1 as gatekeeper of intestinal stem cell identity

Author(s): Nicolas Léveillé, Louis Vermeulen
Published in: Stem Cell Investigation, Issue 3, 2016, Page(s) 22-22, ISSN 2306-9759
Publisher: AmeGroups
DOI: 10.21037/sci.2016.06.03

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

Author(s): Maartje van der Heijden, Daniël M. Miedema, Bartlomiej Waclaw, Veronique L. Veenstra, Maria C. Lecca, Lisanne E. Nijman, Erik van Dijk, Sanne M. van Neerven, Sophie C. Lodestijn, Kristiaan J. Lenos, Nina E. de Groot, Pramudita R. Prasetyanti, Andrea Arricibita Varea, Douglas J. Winton, Jan Paul Medema, Edward Morrissey, Bauke Ylstra, Martin A. Nowak, Maarten F. Bijlsma, Louis Vermeulen
Published in: Proceedings of the National Academy of Sciences, Issue 116/13, 2019, Page(s) 6140-6145, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1813417116

A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue

Author(s): Kristiaan J. Lenos, Sophie C. Lodestijn, Scott K. Lyons, Maarten F. Bijlsma, Daniël M. Miedema, Louis Vermeulen
Published in: Nature Protocols, Issue 14/9, 2019, Page(s) 2648-2671, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-019-0194-y

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Author(s): Kristiaan J. Lenos, Daniël M. Miedema, Sophie C. Lodestijn, Lisanne E. Nijman, Tom van den Bosch, Xavier Romero Ros, Filipe C. Lourenço, Maria C. Lecca, Maartje van der Heijden, Sanne M. van Neerven, Anita van Oort, Nicolas Leveille, Ronja S. Adam, Felipe de Sousa E Melo, Joy Otten, Patrick Veerman, Guillaume Hypolite, Lianne Koens, Scott K. Lyons, Giorgio Stassi, Douglas J. Winton, Jan Paul Med
Published in: Nature Cell Biology, Issue 20/10, 2018, Page(s) 1193-1202, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0179-z

Bcl-2 is a critical mediator of intestinal transformation

Author(s): Maartje van der Heijden, Cheryl D. Zimberlin, Anna M. Nicholson, Selcuk Colak, Richard Kemp, Sybren L. Meijer, Jan Paul Medema, Florian R. Greten, Marnix Jansen, Douglas J. Winton, Louis Vermeulen
Published in: Nature Communications, Issue 7/1, 2016, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms10916

The consensus molecular subtypes of colorectal cancer

Author(s): Justin Guinney, Rodrigo Dienstmann, Xin Wang, Aurélien de Reyniès, Andreas Schlicker, Charlotte Soneson, Laetitia Marisa, Paul Roepman, Gift Nyamundanda, Paolo Angelino, Brian M Bot, Jeffrey S Morris, Iris M Simon, Sarah Gerster, Evelyn Fessler, Felipe De Sousa E Melo, Edoardo Missiaglia, Hena Ramay, David Barras, Krisztian Homicsko, Dipen Maru, Ganiraju C Manyam, Bradley Broom, Valerie Boige, B
Published in: Nature Medicine, Issue 21/11, 2015, Page(s) 1350-1356, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.3967

Wnt Signaling in Cancer Stem Cell Biology

Author(s): Felipe de Sousa e Melo, Louis Vermeulen
Published in: Cancers, Issue 8/7, 2016, Page(s) 60, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers8070060

Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data

Author(s): Anne Trinh, Claudia Lädrach, Heather E. Dawson, Sanne ten Hoorn, Peter J. K. Kuppen, Marlies S. Reimers, Miriam Koopman, Cornelis J. A. Punt, Alessandro Lugli, Louis Vermeulen, Inti Zlobec
Published in: British Journal of Cancer, Issue 119/10, 2018, Page(s) 1244-1251, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-018-0230-7

Balancing signals in the intestinal niche

Author(s): Sanne M Neerven, Louis Vermeulen
Published in: The EMBO Journal, Issue 36/4, 2017, Page(s) 389-391, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201796431

Chromosomal copy number heterogeneity predicts survival rates across cancers

Author(s): Erik van Dijk, Tom van den Bosch, Kristiaan J. Lenos, Khalid El Makrini, Lisanne E. Nijman, Hendrik F. B. van Essen, Nico Lansu, Michiel Boekhout, Joris H. Hageman, Rebecca C. Fitzgerald, Cornelis J. A. Punt, Jurriaan B. Tuynman, Hugo J. G. Snippert, Geert J. P. L. Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M. Miedema
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23384-6

Apc-mutant cells act as supercompetitors in intestinal tumour initiation

Author(s): Sanne M. van Neerven, Nina E. de Groot, Lisanne E. Nijman, Brendon P. Scicluna, Milou S. van Driel, Maria C. Lecca, Daniël O. Warmerdam, Vaishali Kakkar, Leandro F. Moreno, Felipe A. Vieira Braga, Delano R. Sanches, Prashanthi Ramesh, Sanne ten Hoorn, Arthur S. Aelvoet, Marouska F. van Boxel, Lianne Koens, Przemek M. Krawczyk, Jan Koster, Evelien Dekker, Jan Paul Medema, Douglas J. Winton, Maarte
Published in: Nature, Issue 594/7863, 2021, Page(s) 436-441, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03558-4

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