Objective
Cardiac Ventricular Remodelling (VR), i.e. the alteration of tissue microstructure that is a hallmark of several cardiac diseases, can have profound effects on cardiac function. A novel imaging technique, Diffusion Tensor Imaging (DTI) offers the potential to quantify VR in vivo and could thus have a significant impact on the assessment and treatment of cardiac disease. This project proposes the development of advanced analytical tools to evaluate its usability in the quantitative characterization of cardiac microstructure. The tools developed will aim at a) providing a mathematical description of normality in cardiac microstructure; and b) analysing local variation as an alternative descriptor for remodelling. A combination of preclinical and clinical validation will be performed, with histological slices used as ground truth for the identification of microstructural features. Emphasis will be placed on the development and application of a rigorous mathematical framework for the processing of tensor fields, including the quantification of local differences between tensors and the construction of statistical models for the quantification of pathology.
The project joins an early researcher with extensive expertise in the statistical analysis of manifold-value data and its uses in medical imaging with an internationally recognized group in the analysis of cardiac microstructure and its links to electromechanical function. The host group has a network of collaborators including all relevant areas, from MRI physics to cardiac physiology. The program also includes the provision of further training opportunities for the applicant in different aspects from student supervision to preparation of research proposals, representing a unique opportunity for his development as an independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology
- medical and health sciences basic medicine anatomy and morphology
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology
- natural sciences computer and information sciences artificial intelligence machine learning deep learning
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.