Objetivo The aim of this study is to develop piezoelectric ceramics for the use as bone replacement materials utilizing their piezoelectric behaviour to stimulate bone and vascular cell growth. The work is based on the finding that mechanical and electrical stimuli exert a strong influence on the osseogenesis on the cellular level. As piezoelectric ceramics develop electric surface charges under mechanical load it is expected that they accelerate the healing process and support the development of a strong bond between bone and implant.The quality of bone and vascular ingrowth is determined by various factors such as biocompatibility of the replacement material, surface morphology and electric surface states. Especially the porosity of the ceramic is of crucial importance as the pores have to be large enough and of open structure to allow ingrowth of both bone and vascular cells. However, increasing porosity is likely to alter the local piezoelectric behaviour and by this the local surface charges responsible for cell growth stimulation. To pave the way for the development of piezoelectric implants it is crucial to understand the influence of microstructural features such as porosity and grain size on the piezoelectric properties. I will approach this task by developing biocompatible ceramics with a wide range of microstructural characteristics. I will investigate the influence of porosity and grain size on a macroscopic scale using piezoelectric testing techniques, on a mesoscopic scale employing Piezo Force Microscopy and on the structural scale via diffraction studies. The biocompatibility as well as the influence of the piezoelectric behaviour on the osseogenesis will be clarified by in-vitro cell experiments on unpoled and electrically poled ceramics. The knowledge gained will form the basis for the development of a new class of implant materials exploiting the piezoelectric characteristics to improve the healing process and to create long lasting interfacial bonds. Ámbito científico engineering and technologymaterials engineeringceramicsmedical and health sciencesmedical biotechnologyimplantsartificial bone Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Convocatoria de propuestas H2020-MSCA-IF-2014 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-ST - Standard EF Coordinador NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Aportación neta de la UEn € 208 400,40 Dirección HOGSKOLERINGEN 1 7491 Trondheim Noruega Ver en el mapa Región Norge Trøndelag Trøndelag Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 208 400,40