Objective
Depressive symptoms frequently occur during pregnancy and may have a tremendous impact on the developing child. Unfortunately, pharmacological antidepressant treatments during pregnancy can negatively impact behavioral development and health of the offspring. In humans it is difficult to discern between the effects of the drug and the effects of the depression itself, therefore it is unclear whether children exposed to antidepressants in utero are at increased risk, and if so, what the underlying molecular mechanisms are that may point to potential solutions.
My overall aim is to identify molecular mechanisms and behavioral alterations in the offspring due to antenatal depression, antidepressant treatment during pregnancy, and their combination. To achieve this goal I will use an advanced rat model for depression to allow an experimental approach. I will identify the effects of antenatal depression, antidepressant treatment during pregnancy, and their combination on: (1) behavior of the offspring, (2) gene expression patterns with micro-array in the fetal brain, and (3) epigenetic profile of genes from the micro-array in adult brain and blood plasma.
So far, Genome Wide Association Studies have not yielded new targets for the treatment of depressed (pregnant) patients.
The outcome of this study will not only advance our knowledge on genes underlying the alterations found in brain and blood of the offspring due to antenatal depression, antidepressant treatment and their combination, but will also reveal early biomarkers as the epigenetic profile for the altered genes are studied. Ultimately, the results of this project will be beneficial for human health as it will open up new avenues for biomedical research and therapeutic applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine obstetrics
- natural sciences biological sciences microbiology
- natural sciences biological sciences genetics epigenetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9712CP Groningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.