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Towards solving myopia: from genes to pathways using an integrated approach

Towards solving myopia: from genes to pathways using an integrated approach

Objective

Background:
Myopia (near-sightedness) is a growing public health issue due to its rapidly rising prevalence. In particular high myopia carries a significant risk of blindness for which there are no treatment options. The disease etiology of this trait is complex and largely unknown. We recently identified a large number of disease loci and genes, which provide significant clues for pathogenic pathways. However, they explain only a limited proportion of myopia’s heritability, and the direct functional effects of risk variants, their interaction with environmental factors, and their potential for intervention are unknown.
Aim:
To identify disease mechanisms that underlie myopia and create starting points for therapy.
Approach:
1. Decipher the genetic background of myopia, identify gene effects and influence of environment in humans.
In very large consortia (~250,000 study participants) with ample data on epidemiology, myopia phenotype, and genomic markers, we will exploit the recent technological advances to analyze a large number of genetic variants including those altering protein function. We will annotate significant hits to major pathways, study gene effects on phenotype, identify retinal cell structures which drive myopiagenesis, investigate gene-environment interaction, and develop a prediction model for progression to high myopia.
2. Identify gene effects, influence of environment, and targets for intervention in animals.
In mice and zebrafish which have been manipulated for high myopia risk genes, we will study ocular biometry, retinal anatomy, visual behavior, and molecular and biochemical effects of genes as a function of environment. Interventions tailored to altering gene effects will be explored.
Impact:
Integrating the results obtained from these genetic, epidemiologic, functional and molecular studies will advance our understanding of the underlying biology of myopia and help create novel therapeutic targets to reduce the burden of high myopia.

Host institution

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Address

Dr Molewaterplein 40
3015 Gd Rotterdam

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 000 000

Beneficiaries (1)

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ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 2 000 000

Project information

Grant agreement ID: 648268

Status

Ongoing project

  • Start date

    1 September 2015

  • End date

    31 August 2020

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 000 000

  • EU contribution

    € 2 000 000

Hosted by:

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands