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Design of polyPEPTIdes diblock copolymers as emulsifiers to produce safe, controlled and reliable novel stimuli-responsive nanoCAPSules for skin care applications

Design of polyPEPTIdes diblock copolymers as emulsifiers to produce safe, controlled and reliable novel stimuli-responsive nanoCAPSules for skin care applications

Objective

PeptiCaps aims at producing and validating a new family of stimuli-responsive nanocapsules able to encapsulate efficiently and protect specific active ingredients for skin care application. Those nanocapsules will be assembled by nanoemulsion technique using amphiphilic and biocompatible polypeptides diblock copolymers with one hydrophilic poly(ethylene glycol) block and one hydrophobic polypeptide block. Adjustment of the length of each block to finely tune the hydrophilic/Lipophilic balance of the macroemulsifier will allow the encapsulation of either hydrophobic or hydrophilic active ingredients. In addition, polypeptides block will be specifically designed to respond to changes in pH and the presence of enzyme occurring for the skin conditions targeted to allow a triggered release of the active ingredient. After scaling-up selected macroemulsifiers under GMP-like process, two manufacturing processes will be used for the production of the nanocapsules, i.e. high-pressure homogenizer and tubular flow contactor. The most promising process will be selected to produce selected nanocapsules. Physico-chemical properties and (eco)toxicity of the nanocapsules will be extensively characterised using techniques and protocols recommended by the EU Cosmetic regulation to establish their risk and safety assessment. The advantages of safe nanocapsules from PeptiCaps will be demonstrated on validated relevant skin models for each application. All results obtained will be gathered to constitute a Dossier for the validation of the nanocapsules as cosmetic product by the authorities. In addition, PeptiCaps will actively participate to the standardization for nano-safety by developing software to predict the toxicity of nanomaterials (CORAL). Finally, a business plan will be elaborated for the commercialization of PeptiCaps nanocapsules for all cosmetic applications as well as other markets (dermatology and food) to ensure full exploitation of the PeptiCaps technology.
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Coordinator

FUNDACION CIDETEC

Address

Paseo Miramon 196 Parque Tecnologico De Miramon
20014 San Sebastian

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 895 000

Participants (8)

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UNIVERSITE DE BORDEAUX

France

EU Contribution

€ 417 278,75

UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA

Spain

EU Contribution

€ 460 656,25

AHAVA DEAD SEA LABORATORIES LTD

Israel

EU Contribution

€ 371 522,50

POLYPEPTIDE THERAPEUTIC SOLUTIONS SL

Spain

EU Contribution

€ 482 875

UNIVERSITE LYON 1 CLAUDE BERNARD

France

EU Contribution

€ 419 093,75

ANGEL CONSULTING SAS DI MATTEO ZANOTTI RUSSO & C

Italy

EU Contribution

€ 147 500

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Italy

EU Contribution

€ 435 500

SPINVERSE OY

Finland

EU Contribution

€ 222 867,50

Project information

Grant agreement ID: 686141

  • Start date

    5 October 2015

  • End date

    4 October 2018

Funded under:

H2020-EU.2.1.2.2.

H2020-EU.2.1.2.5.

H2020-EU.2.1.2.3.

  • Overall budget:

    € 3 852 293,75

  • EU contribution

    € 3 852 293,75

Coordinated by:

FUNDACION CIDETEC

Spain

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