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Scientific Excellence in Animal Reproductive Medicine and Embryo Technology

Deliverables

One Exploitation Plan on working with the pharmaceutical sector

UCPH will provide advice to EMU in analyzing their potential market and developing a go-to-market strategy. This will include determining what if any intellectual property rights can be asserted on the procedures or products that are developed. It will also examine production issues such as scalability and distribution. Financial issues such as pricing strategies, marketing and investments required will also be considered.

Infrastructure Development Strategy

EMU with UCPH assistance will create a strategy for increasing its research excellence through changes in facilities and equipment. The plan will: • Assess the feasibility of EMU reaching a standard of excellence while continuing to use partner facilities in Estonia or abroad • Make a cost-benefit analysis to compare the anticipated scientific benefits to the purchase, operating and maintenance costs of new or upgraded infrastructure in the short, intermediate and long term. • Identify potential sources of funding that could support the upgrade of EMU facilities. This includes state, EU and international programmes as well as alternative financing scheme. The plan will be completed in Month 25. • Determine how EMU should proceed to ensure that it can reach research excellence, be capable of scaling up of embryo production and improve animal welfare.

One Technology Transfer Plan for Bovine Embryo Production

UCPH will help EMU develop its strategy, answering questions of legal arrangements, intellectual property, risk assessments, and financing needs. All of these questions will be addressed in a technology transfer plan.

Bovine IVF Embryo Production Plan

Experts from USFD will work with EMU researchers to create a plan that will lay out how EMU can scale up production of bovine IVF embryos for potential commercialization.

Data Management Plan

EMU will prepare detailed protocols for storing and managing animal reproductive data. The plan will lay out how the data should be managed over the long term so that it can be used in comparisons with other samples to identify changes over time.

One Scenario Analysis on potential methods of commercializing EMU’s bovine embryo development

UCPH will work with EMU to map out the potential methods of commercializing its bovine embryo development techniques. The analysis will include the following: • Providing technology transfer consultation - teaching animal breeders how to produce high quality embryos on their own using the techniques developed at EMU. Perhaps via licensing agreements. • Partnerships for embryo production – working with one or more partners to produce and sell high quality embryos to animal breeders in the Baltics, Ukraine, Belarus, Russia and/or other markets

One Scenario Analysis on potential methods of working with the pharmaceutical sector

EMU, with the help of partners will analyse 3 potential scenarios in regards to working with the pharmaceutical industry. For each method, UTARTU will assess feasibility in terms of infrastructure requirements, potential yields, timeframes for development and initial demand. • Transgenic farm animals as bioreactors to synthesize biopharmaceutical products such as peptides and hormones: This is the scenario that EMU has made the most progress towards, • Transgenic animals as test subjects for drug development where phenotypic and epigenetic information can be monitored. • Inheritable genetic modification to produce animals as bioreactors or test subjects

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Publications

MyHC and MyLC isoforms in Akhal-Teke horses of different gender and genetic background

Author(s): K. Leisson, K. Alev, P. Kaasik, T. Kaart, Ü. Jaakma, T. Seene
Published in: Livestock Science, Issue 157/1, 2013, Page(s) 263-270, ISSN 1871-1413
DOI: 10.1016/j.livsci.2013.05.028

85 LOW-MOLECULAR-WEIGHT METABOLITES IN BOVINE IN VITRO PRODUCTION CULTURE MEDIA AS EMBRYO QUALITY MARKERS

Author(s): M. N�mm, E. Mark, K. Kilk, S. K�ks, �. Jaakma
Published in: Reproduction, Fertility and Development, Issue 27/1, 2015, Page(s) 135, ISSN 1031-3613
DOI: 10.1071/RDv27n1Ab85

Sequencing and annotated analysis of the Holstein cow genome

Author(s): Sulev Kõks, Rutt Lilleoja, Ene Reimann, Andres Salumets, Paula Reemann, Ülle Jaakma
Published in: Mammalian Genome, Issue 24/7-8, 2013, Page(s) 309-321, ISSN 0938-8990
DOI: 10.1007/s00335-013-9464-0

Sexually active groups in cattle—A novel estrus sign

Author(s): G. Sveberg, A.O. Refsdal, H.W. Erhard, E. Kommisrud, M. Aldrin, I.F. Tvete, F. Buckley, A. Waldmann, E. Ropstad
Published in: Journal of Dairy Science, Issue 96/7, 2013, Page(s) 4375-4386, ISSN 0022-0302
DOI: 10.3168/jds.2012-6407

49 EFFECTS OF CULTURE CONDITIONS AND GENE TRANSFECTION ON THE DEVELOPMENT OF BOVINE SOMATIC CELL NUCLEAR TRANSFER EMBRYOS

Author(s): P. Pärn, M. Plaas, M. Nõmm, Ü. Jaakma, S. Kõks
Published in: Reproduction, Fertility and Development, Issue 25/1, 2013, Page(s) 172, ISSN 1031-3613
DOI: 10.1071/RDv25n1Ab49

Uterine bacterial flora in postpartum Danish Holstein dairy cows determined using DNA-based fingerprinting: Correlation to uterine condition and calving management

Author(s): K. Elkjær, M.-L. Ancker, H. Gustafsson, N.C. Friggens, A. Waldmann, L. Mølbak, H. Callesen
Published in: Animal Reproduction Science, Issue 138/1-2, 2013, Page(s) 39-48, ISSN 0378-4320
DOI: 10.1016/j.anireprosci.2013.01.016

The relationship between fatty acid profiles in milk identified by Fourier transform infrared spectroscopy and onset of luteal activity in Norwegian dairy cattle

Author(s): Martin, A.D.; Afseth, N.K.; Kohler, A.; Randby, Å.; Eknæs, M., Waldmann, A.; Dørum, G.; Måge, I; Reksen, O.
Published in: Journal of Dairy Science, 2015, ISSN 0022-0302
DOI: 10.3168/jds.2015-9343

Comparison of Holstein-Friesian and Norwegian Red dairy cattle for estrus length and estrous signs

Author(s): G. Sveberg, G.W. Rogers, J. Cooper, A.O. Refsdal, H.W. Erhard, E. Kommisrud, F. Buckley, A. Waldmann, E. Ropstad
Published in: Journal of Dairy Science, Issue 98/4, 2015, Page(s) 2450-2461, ISSN 0022-0302
DOI: 10.3168/jds.2014-8905

Bovine sperm plasma membrane proteomics through biotinylation and subcellular enrichment

Author(s): Sergo Kasvandik, Gerly Sillaste, Agne Velthut-Meikas, Aavo-Valdur Mikelsaar, Triin Hallap, Peeter Padrik, Tanel Tenson, Ülle Jaakma, Sulev Kõks, Andres Salumets
Published in: PROTEOMICS, Issue 15/11, 2015, Page(s) 1906-1920, ISSN 1615-9853
DOI: 10.1002/pmic.201400297

Influence of the uterine inflammatory response after insemination with frozen–thawed semen on serum concentrations of acute phase proteins in mares

Author(s): U. Tuppits, T. Orro, S. Einarsson, K. Kask, A. Kavak
Published in: Animal Reproduction Science, Issue 146/3-4, 2014, Page(s) 182-186, ISSN 0378-4320
DOI: 10.1016/j.anireprosci.2014.02.007

Relationship between acute phase proteins and subsequent fertility of dairy cows after postpartum uterine inflammation.

Author(s): Jeremejeva, J.; Orro, T.; Kask, K.
Published in: Veterinarija ir Zootechnika, 2015, ISSN 1392-2130

Sex- and Age-Related Morphological Characteristics of European Elk ( Alces alces ) Pelves

Author(s): E. Nahkur, E. Ernits, V. Andrianov, M. Jalakas, E. Järv
Published in: Anatomia, Histologia, Embryologia, Issue 43/4, 2014, Page(s) 273-281, ISSN 0340-2096
DOI: 10.1111/ahe.12072

Bacillus Smithii TBMI12 endospores as a potential komponent of probiotic feed addative for pigs

Author(s): Suitso, I.; Jõgi, E.; Orro, T.; Kavak, A.; Kalmus, K.; Viltrop, A.; Nurk, A.
Published in: Veterinarija ir Zootechnica, 2014, ISSN 1392-2130

Histochemical and Immunohistochemical Investigation of Pelvic Symphysis in Holstein-Friesian Cattle

Author(s): Hussar, Piret; Järveots, Tõnu; Jalakas, Mihkel
Published in: Papers on Anthropology, 2015, ISSN 1406-0140
DOI: 10.12697/issn1406-0140

Blood plasma variables as indicators of cytological endometritis risk in multiparous Holstein dairy cows

Author(s): Waldmann, A.; Valdmann, M.; Kurykin, J.; Mällo, G.-K.; Kaart, T.; Larsen, T.
Published in: 15th International Conference on Production Diseases on Farm Animals. Book of Abstracts, 2013

Current Investigations into Dairy Cow Welfare at the Estonian University of Life Sciences

Author(s): Arney, David; Jaakson, Hanno; Henno, Merike; Valdmann, Andres; Ling, Katri
Published in: Proceedings of the First DairyCare Conference 2014, 2014

Cytological evaluation of uterine health status in the cow

Author(s): Waldmann, A.; Valdmann, M.; Kurykin, J.; Mällo, G.-K.; Kaart, T.; Larsen, T.
Published in: UTERINE HEALTH. Proceedings from a European seminar in Uppsala, Sweden, November 7, 2013., 2014

Lateral flow milk progesterone test - comparisons with EIA for confirmation of oestrus and nonpregnancy diagnosis in cows

Author(s): Waldmann, A.; Raud, A.
Published in: Reproduction in Domestic Animals, 2015

Blood plasma insulin-like growth factor 1 (IGF-1) concentrations in combination with the cytological endometritis status as predictors for reproductive performance and likelihood of culling in multiparous dairy cows.

Author(s): Waldmann, A.; Valdmann, M.; Kurykin, J.; Kaart, T.; Mällo, G.-K. In: JL Juengel, A Miyamoto, C Price, LP Reynolds, MF Smith, R Webb.
Published in: Proceedings of the Ninth International Symposium on Reproduction in Domestic Ruminants, 2014

Effects of milk progesterone and activity level on pregnancy rate in dairy cows using the Ovsynch protocol. 

Author(s): Kiiver, H.; Kommisrud, E.; Soidra, K.; Waldmann, A.
Published in: Reproduction in Domestic Animals, 2015

Effect of season and storage time on boar semen motility in Estonia

Author(s): Kavak, Ants; Kütt, Pille; Kaart, Tanel
Published in: Reproduction in Domestic Animals, 2015

Effect of season and breed on boar semen quality in Estonia

Author(s): Kavak, Ants; Kütt, Pille; Kaart, Tanel
Published in: Reproduction in Domestic Animals, 2014

Ossification of the pelvic symphysis in ruminants

Author(s): Nahkur, E.; Ernits, E.; Andrianov, V.; Jalakas, M.; Järv, E.
Published in: Anatomia, Histologia, Embryologia, 2014

The metagenomic analysis of the mares’ intrauterine fluid

Author(s): Tuppits, Ulrika; Orro, Toomas; Einarsson, Stig; Salumets, Andres; Truu, Jaak; Kavak, Ants
Published in: Reproduction in Domestic Animals, 2014