Objective
The overall aim of LIQBIOPSENS project is the further development and validation in real settings of a novel diagnostic platform for the early and fast detection of ctDNA and their KRAS and BRAF mutations associated to colorectal cancer through blood samples. The main features of LIQBIOPSENS are: reliability (detection rates vary from 95–100 %), low-cost (40-50 € per sample analysis), sensitivity (in the zM range), multiplexing capabilities (analysis of 27 KRAS and BRAF mutations simultaneously), short analysis time (30-60 min.), user-friendly interface and flexibility. Solution proposed by the LIQBIOPSENS project relies on the multidisciplinary integration of different Key Enabled Technologies: microelectronics, microfluidics, nanomaterials and genomics. In particular, LIQBIOPSENS platform is based on the integration of two novel complementary technologies. On the one hand, the revolutionary DGL© technology property of DestiNA Genomics Ltd, capable of delivering faster, more error-free detection of nucleic acids and their mutations than current enzyme-based detection systems, making 'false positive' results a thing of the past. On the other hand, a novel high resolution acoustic wave microsensor technology property of AWSensors, that allows an accurate, inexpensive, label-free, direct and real time transduction method to quantitatively evaluate the results of the application of the above mentioned DGL© technique.
Fields of science
- medical and health scienceshealth sciencespublic health
- medical and health sciencesclinical medicineoncologylung cancer
- medical and health sciencesclinical medicineoncologybreast cancer
- medical and health sciencesclinical medicineoncologycolorectal cancer
- natural sciencesbiological sciencesgeneticsmutation
Programme(s)
Topic(s)
Funding Scheme
IA - Innovation action
Coordinator
46005 Valencia
Spain
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Participants (7)
EH3 7JA Edinbourgh
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
18100 Granada
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
70013 Irakleio
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41071 Sevilla
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Participation ended
28004 Madrid
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1348 Louvain La Neuve
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46980 Paterna
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.