CORDIS
EU research results

CORDIS

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Reliable Novel Liquid Biopsy technology for early detection of colorectal cancer

Project information

Grant agreement ID: 687785

  • Start date

    1 January 2016

  • End date

    31 December 2018

Funded under:

H2020-EU.2.1.1.

  • Overall budget:

    € 2 702 268,75

  • EU contribution

    € 2 307 200,63

Coordinated by:

ADVANCED WAVE SENSORS S.L.

Spain

Objective

The overall aim of LIQBIOPSENS project is the further development and validation in real settings of a novel diagnostic platform for the early and fast detection of ctDNA and their KRAS and BRAF mutations associated to colorectal cancer through blood samples. The main features of LIQBIOPSENS are: reliability (detection rates vary from 95–100 %), low-cost (40-50 € per sample analysis), sensitivity (in the zM range), multiplexing capabilities (analysis of 27 KRAS and BRAF mutations simultaneously), short analysis time (30-60 min.), user-friendly interface and flexibility. Solution proposed by the LIQBIOPSENS project relies on the multidisciplinary integration of different Key Enabled Technologies: microelectronics, microfluidics, nanomaterials and genomics. In particular, LIQBIOPSENS platform is based on the integration of two novel complementary technologies. On the one hand, the revolutionary DGL© technology property of DestiNA Genomics Ltd, capable of delivering faster, more error-free detection of nucleic acids and their mutations than current enzyme-based detection systems, making 'false positive' results a thing of the past. On the other hand, a novel high resolution acoustic wave microsensor technology property of AWSensors, that allows an accurate, inexpensive, label-free, direct and real time transduction method to quantitatively evaluate the results of the application of the above mentioned DGL© technique.
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Coordinator

ADVANCED WAVE SENSORS S.L.

Address

C/ Ciscar 40-8
46005 Valencia

Spain

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU Contribution

€ 415 668,75

Participants (6)

DESTINA GEONOMICS LTD

United Kingdom

EU Contribution

€ 386 281,88

IDRYMA TECHNOLOGIAS KAI EREVNAS

Greece

EU Contribution

€ 450 000

SERVICIO ANDALUZ DE SALUD

Spain

EU Contribution

€ 433 750

BEABLE SL

Spain

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

EU Contribution

€ 501 625

SISTEMAS GENOMICOS SL

Spain

EU Contribution

€ 119 875

Project information

Grant agreement ID: 687785

  • Start date

    1 January 2016

  • End date

    31 December 2018

Funded under:

H2020-EU.2.1.1.

  • Overall budget:

    € 2 702 268,75

  • EU contribution

    € 2 307 200,63

Coordinated by:

ADVANCED WAVE SENSORS S.L.

Spain