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Reliable Novel Liquid Biopsy technology for early detection of colorectal cancer

Objective

The overall aim of LIQBIOPSENS project is the further development and validation in real settings of a novel diagnostic platform for the early and fast detection of ctDNA and their KRAS and BRAF mutations associated to colorectal cancer through blood samples. The main features of LIQBIOPSENS are: reliability (detection rates vary from 95–100 %), low-cost (40-50 € per sample analysis), sensitivity (in the zM range), multiplexing capabilities (analysis of 27 KRAS and BRAF mutations simultaneously), short analysis time (30-60 min.), user-friendly interface and flexibility. Solution proposed by the LIQBIOPSENS project relies on the multidisciplinary integration of different Key Enabled Technologies: microelectronics, microfluidics, nanomaterials and genomics. In particular, LIQBIOPSENS platform is based on the integration of two novel complementary technologies. On the one hand, the revolutionary DGL© technology property of DestiNA Genomics Ltd, capable of delivering faster, more error-free detection of nucleic acids and their mutations than current enzyme-based detection systems, making 'false positive' results a thing of the past. On the other hand, a novel high resolution acoustic wave microsensor technology property of AWSensors, that allows an accurate, inexpensive, label-free, direct and real time transduction method to quantitatively evaluate the results of the application of the above mentioned DGL© technique.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid
  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/physical sciences/electromagnetism and electronics/microelectronics
  • /engineering and technology/nanotechnology/nano-materials
  • /medical and health sciences/clinical medicine/oncology/cancer/colorectal cancer

Call for proposal

H2020-ICT-2015
See other projects for this call

Funding Scheme

IA - Innovation action

Coordinator

ADVANCED WAVE SENSORS S.L.
Address
C/ Ciscar 40-8
46005 Valencia
Spain
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 415 668,75

Participants (6)

DESTINA GEONOMICS LTD
United Kingdom
EU contribution
€ 386 281,88
Address
7 11 Melville Street
EH3 7JA Edinbourgh
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
EU contribution
€ 450 000
Address
N Plastira Str 100
70013 Irakleio
Activity type
Research Organisations
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 433 750
Address
Avenida De La Constitucion 18
41071 Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
BEABLE SL

Participation ended

Spain
EU contribution
€ 0
Address
Calle Genova 7 5 Izq Esc Int 7
28004 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
EU contribution
€ 501 625
Address
Place De L Universite 1
1348 Louvain La Neuve
Activity type
Higher or Secondary Education Establishments
SISTEMAS GENOMICOS SL
Spain
EU contribution
€ 119 875
Address
Ronda G Marconi - Parque Tecnologico De Valencia 6
46980 Paterna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)