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Reliable Novel Liquid Biopsy technology for early detection of colorectal cancer

Objective

The overall aim of LIQBIOPSENS project is the further development and validation in real settings of a novel diagnostic platform for the early and fast detection of ctDNA and their KRAS and BRAF mutations associated to colorectal cancer through blood samples. The main features of LIQBIOPSENS are: reliability (detection rates vary from 95–100 %), low-cost (40-50 € per sample analysis), sensitivity (in the zM range), multiplexing capabilities (analysis of 27 KRAS and BRAF mutations simultaneously), short analysis time (30-60 min.), user-friendly interface and flexibility. Solution proposed by the LIQBIOPSENS project relies on the multidisciplinary integration of different Key Enabled Technologies: microelectronics, microfluidics, nanomaterials and genomics. In particular, LIQBIOPSENS platform is based on the integration of two novel complementary technologies. On the one hand, the revolutionary DGL© technology property of DestiNA Genomics Ltd, capable of delivering faster, more error-free detection of nucleic acids and their mutations than current enzyme-based detection systems, making 'false positive' results a thing of the past. On the other hand, a novel high resolution acoustic wave microsensor technology property of AWSensors, that allows an accurate, inexpensive, label-free, direct and real time transduction method to quantitatively evaluate the results of the application of the above mentioned DGL© technique.

Coordinator

ADVANCED WAVE SENSORS S.L.
Net EU contribution
€ 415 668,75
Address
C/ Ciscar 40-8
46005 Valencia
Spain

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 415 668,75

Participants (7)

DESTINA GEONOMICS LTD
United Kingdom
Net EU contribution
€ 317 944,38
Address
7 11 Melville Street
EH3 7JA Edinbourgh

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
North Eastern Scotland Aberdeen City and Aberdeenshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 317 944,38
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

DESTINA GENOMICA SLNE
Spain
Net EU contribution
€ 68 337,50
Address
Avenida De La Innoaci0n 1 Edificio Bic
18100 Granada

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Andalucía Granada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 68 337,50
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
Net EU contribution
€ 450 000,00
Address
N Plastira Str 100
70013 Irakleio

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Region
Ηράκλειο Κρήτη Νησιά Αιγαίου
Activity type
Research Organisations
Other funding
€ 450 000,00
SERVICIO ANDALUZ DE SALUD
Spain
Net EU contribution
€ 433 750,00
Address
Avenida De La Constitucion 18
41071 Sevilla

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Region
Andalucía Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 433 750,00
BEABLE SL

Participation ended

Spain
Net EU contribution
€ 0,00
Address
Calle Genova 7 5 Izq Esc Int 7
28004 Madrid
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
Net EU contribution
€ 501 625,00
Address
Place De L Universite 1
1348 Louvain La Neuve

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Region
Région wallonne Prov. Brabant Wallon Arr. Nivelles
Activity type
Higher or Secondary Education Establishments
Other funding
€ 501 625,00
SISTEMAS GENOMICOS SL
Spain
Net EU contribution
€ 119 875,00
Address
Ronda G Marconi - Parque Tecnologico De Valencia 6
46980 Paterna

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Comunitat Valenciana Valencia/València
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 119 875,00