Objective
Restoring normal vessel structure and function is now considered as a highly promising therapeutic opportunity for angiogenesis-related diseases, including cancer. Despite extensive use of microtubule targeting compounds in vascular-directed anticancer treatment, knowledge of the cellular mechanisms underlying microtubule regulation during angiogenesis is still elusive. By combining my previous experience in endothelial cell biology and the long term expertise of the host laboratory in microtubules dynamics as well as in high resolution imaging techniques, our project is aimed at studying microtubule dynamics and microtubule function in the precise context of sprouting angiogenesis. To achieve that goal, we propose to address the role of microtubule regulatory proteins using advanced high resolution live imaging of 3D culture of endothelial cells. We will identify endothelial specific MT regulators through expression, interaction and functional studies, assess their impact on microtubule dynamics during 3D tubulogenesis and validate their role both in the 3D morphogenesis model and in vivo, using zebrafish. This project is aimed at answering fundamental questions in the angiogenesis field as well as providing new opportunities for therapeutic strategies. At the same time, my experience in the laboratory of Dr Akhmanova will allow me to develop knowledge and skills in order to prepare me to reach a position of professional maturity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology cell polarity
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3584 CS Utrecht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.