The evolutionary significance of synonymous variations: Can codon usage preferences drive the propagation of antibiotic resistance?

Projektinformationen

HGTCODONUSE

ID Finanzhilfevereinbarung: 682819

DOI 10.3030/682819

Projekt abgeschlossen

EK-Unterschriftsdatum 13 April 2016

Startdatum 1 Juni 2016

Enddatum 31 Mai 2022

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 1 992 366,00

EU-Beitrag € 1 992 366,00

Koordiniert durch

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Ziel

The intensive use of antibiotics provided an unprecedented improvement in infectious disease treatments but at the expense of creating ideal conditions for the selection of widespread resistance. Propagation of antibiotic resistances is favoured by horizontal gene transfer and by bacterial life in multispecies community. However, compositions of resistome and bacterial communities are often correlated, suggesting that propagation of resistances does not occur at random. This project will test the hypothesis that mismatch in codon preferences between the transferred genes and the receiving genome is a fundamental factor shaping resistome structure and evolution. Such central role of codon preferences may have been hitherto overlooked. The project combines mutant collection characterization, experimental evolution approaches –one in a multispecies context and one in a variable environment context-, full genome sequencing of evolved populations, phylogenomics and mathematical modelling integrating the experimental results of the other approaches, and generating a predictive tool about the evolutionary outcome of various real-life situations.

Wissenschaftliches Gebiet

• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › microbiology › bacteriology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antibiotics
• natural sciences › biological sciences › genetics › genomes
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance › antibiotic resistance

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-CoG-2015 - ERC Consolidator Grant

Aufforderung zur Vorschlagseinreichung

ERC-2015-CoG

Finanzierungsplan

ERC-COG - Consolidator Grant

Gastgebende Einrichtung

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

• Netto-EU-Beitrag: € 1 992 366,00
• Adresse: RUE MICHEL ANGE 3 ; 75794 Paris ; Frankreich
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: € 1 992 366,00

Begünstigte (1)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Frankreich

• Netto-EU-Beitrag: € 1 992 366,00
• Adresse: RUE MICHEL ANGE 3 ; 75794 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: € 1 992 366,00