Multi-scale model of bacterial cell-cell interactions

Project Information

T6S

Grant agreement ID: 679209

DOI 10.3030/679209

Project closed

EC signature date 20 May 2016

Start date 1 January 2017

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 751 853,00

EU contribution € 1 751 853,00

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

Publications

Peer reviewed articles (23)

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

Author(s): Annika Hausmann, Desirée Böck, Petra Geiser, Dorothée L. Berthold, Stefan A. Fattinger, Markus Furter, Judith A. Bouman, Manja Barthel-Scherrer, Crispin M. Lang, Erik Bakkeren, Isabel Kolinko, Médéric Diard, Dirk Bumann, Emma Slack, Roland R. Regoes, Martin Pilhofer, Mikael E. Sellin, Wolf-Dietrich Hardt
Published in: Mucosal Immunology, Issue 13/3, 2020, Page(s) 530-544, ISSN 1933-0219
Publisher: Nature Publishing Group
DOI: 10.1038/s41385-019-0247-0

Structure and Function of a Bacterial Gap Junction Analog

Author(s): Gregor L. Weiss, Ann-Katrin Kieninger, Iris Maldener, Karl Forchhammer, Martin Pilhofer
Published in: Cell, Issue 178/2, 2019, Page(s) 374-384.e15, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.05.055

Architecture and function of human uromodulin filaments in urinary tract infections

Author(s): Gregor L. Weiss, Jessica J. Stanisich, Maximilian M. Sauer, Chia-Wei Lin, Jonathan Eras, Dawid S. Zyla, Johannes Trück, Olivier Devuyst, Markus Aebi, Martin Pilhofer, Rudi Glockshuber
Published in: Science, Issue 369/6506, 2020, Page(s) 1005-1010, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz9866

Structural Determinants and Their Role in Cyanobacterial Morphogenesis.

Author(s): Benjamin Lennart Springstein; Dennis J. Nürnberg; Gregor L. Weiss; Martin Pilhofer; Karina Stucken
Published in: Life, Issue 1, 2020, ISSN 2075-1729
Publisher: nd
DOI: 10.17169/refubium-29294

Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis

Author(s): Jingwei Xu, Charles F. Ericson, Yun-Wei Lien, Florentine U. N. Rutaganira, Fabian Eisenstein, Miki Feldmüller, Nicole King, Martin Pilhofer
Published in: Nature Microbiology, 2022, ISSN 2058-5276
Publisher: nd
DOI: 10.1038/s41564-022-01059-2

Cryo-Electron Tomography Reveals the Complex Ultrastructural Organization of Multicellular Filamentous Chloroflexota (Chloroflexi) Bacteria

Author(s): Vasil A. Gaisin, Romain Kooger, Denis S. Grouzdev, Vladimir M. Gorlenko, Martin Pilhofer
Published in: Frontiers in Microbiology, Issue 11, 2020, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2020.01373

Fully automated, sequential focused ion beam milling for cryo-electron tomography

Author(s): Tobias Zachs, Andreas Schertel, João Medeiros, Gregor L Weiss, Jannik Hugener, Joao Matos, Martin Pilhofer
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.52286

Mechanistic insight into bacterial entrapment by septin cage reconstitution

Author(s): Damián Lobato-Márquez , Jingwei Xu , Gizem Özbaykal Güler , Adaobi Ojiakor , Martin Pilhofer , Serge Mostowy
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24721-5

In situ architecture, function, and evolution of a contractile injection system

Author(s): Désirée Böck, João M. Medeiros, Han-Fei Tsao, Thomas Penz, Gregor L. Weiss, Karin Aistleitner, Matthias Horn, Martin Pilhofer
Published in: Science, Issue 357/6352, 2017, Page(s) 713-717, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aan7904

Robust workflow and instrumentation for cryo-focused ion beam milling of samples for electron cryotomography

Author(s): João M. Medeiros, Désirée Böck, Gregor L. Weiss, Romain Kooger, Roger A. Wepf, Martin Pilhofer
Published in: Ultramicroscopy, Issue 190, 2018, Page(s) 1-11, ISSN 0304-3991
Publisher: Elsevier BV
DOI: 10.1016/j.ultramic.2018.04.002

The in situ structures of mono-, di-, and trinucleosomes in human heterochromatin

Author(s): Shujun Cai, Désirée Böck, Martin Pilhofer, Lu Gan
Published in: Molecular Biology of the Cell, Issue 29/20, 2018, Page(s) 2450-2457, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e18-05-0331

Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis

Author(s): Masanori Toyofuku, Gerardo Cárcamo-Oyarce, Tatsuya Yamamoto, Fabian Eisenstein, Chien-Chi Hsiao, Masaharu Kurosawa, Karl Gademann, Martin Pilhofer, Nobuhiko Nomura, Leo Eberl
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-00492-w

In situ and high‐resolution cryo‐EM structure of a bacterial type VI secretion system membrane complex

Author(s): Chiara Rapisarda, Yassine Cherrak, Romain Kooger, Victoria Schmidt, Riccardo Pellarin, Laureen Logger, Eric Cascales, Martin Pilhofer, Eric Durand, Rémi Fronzes
Published in: The EMBO Journal, Issue 38/10, 2019, Page(s) e100886, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018100886

Bidirectional contraction of a type six secretion system

Author(s): Piotr Szwedziak, Martin Pilhofer
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09603-1

A contractile injection system stimulates tubeworm metamorphosis by translocating a proteinaceous effector

Author(s): Charles F Ericson, Fabian Eisenstein, João M Medeiros, Kyle E Malter, Giselle S Cavalcanti, Robert W Zeller, Dianne K Newman, Martin Pilhofer, Nicholas J Shikuma
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.46845

Improved applicability and robustness of fast cryo-electron tomography data acquisition

Author(s): Fabian Eisenstein, Radostin Danev, Martin Pilhofer
Published in: Journal of Structural Biology, Issue 208/2, 2019, Page(s) 107-114, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2019.08.006

A Bacterial Phage Tail-like Structure Kills Eukaryotic Cells by Injecting a Nuclease Effector

Author(s): Iara Rocchi, Charles F. Ericson, Kyle E. Malter, Sahar Zargar, Fabian Eisenstein, Martin Pilhofer, Sinem Beyhan, Nicholas J. Shikuma
Published in: Cell Reports, Issue 28/2, 2019, Page(s) 295-301.e4, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.06.019

Effector loading onto the VgrG carrier activates type VI secretion system assembly

Author(s): Chih‐Feng Wu, Yun‐Wei Lien, Devanand Bondage, Jer‐Sheng Lin, Martin Pilhofer, Yu‐Ling Shih, Jeff H Chang, Erh‐Min Lai
Published in: EMBO reports, Issue 21/1, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201947961

Cultivation of a vampire: ‘Candidatus Absconditicoccus praedator’

Author(s): Michail M. Yakimov,Alexander Y. Merkel,Vasil A. Gaisin,Martin Pilhofer,Enzo Messina,John E. Hallsworth,Alexandra A. Klyukina,Ekaterina N. Tikhonova,Vladimir M. Gorlenko
Published in: Environmental Microbiology, 2021, ISSN 1462-2920
Publisher: tbd
DOI: 10.1111/1462-2920.15823

The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism

Author(s): Jessica J Stanisich, Dawid S Zyla, Pavel Afanasyev, Jingwei Xu, Anne Kipp, Eric Olinger, Olivier Devuyst, Martin Pilhofer, Daniel Boehringer, Rudi Glockshuber
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60265

The Polar Legionella Icm/Dot T4SS Establishes Distinct Contact Sites with the Pathogen Vacuole Membrane

Author(s): Désirée Böck; Dario Hüsler; Bernhard Steiner; João M. Medeiros; Amanda Welin; Katarzyna A. Radomska; Wolf-Dietrich Hardt; Martin Pilhofer; Hubert Hilbi
Published in: mBio, Issue 1, 2021, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mbio.02180-21

Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium

Author(s): Stefan A. Fattinger, Desirée Böck, Maria Letizia Di Martino, Sabrina Deuring, Pilar Samperio Ventayol, Viktor Ek, Markus Furter, Saskia Kreibich, Francesco Bosia, Anna A. Müller-Hauser, Bidong D. Nguyen, Manfred Rohde, Martin Pilhofer, Wolf-Dietrich Hardt, Mikael E. Sellin
Published in: PLOS Pathogens, Issue 16/5, 2020, Page(s) e1008503, ISSN 1553-7374
Publisher: plos
DOI: 10.1371/journal.ppat.1008503

Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria

Author(s): Gregor L. Weiss, Fabian Eisenstein, Ann-Katrin Kieninger, Jingwei Xu, Hannah A. Minas, Milena Gerber, Miki Feldmüller, Iris Maldener, Karl Forchhammer, Martin Pilhofer
Published in: Nature Microbiology, 2022, ISSN 2058-5276
Publisher: nd
DOI: 10.1038/s41564-021-01055-y