CHECKPOINTS IN CHECK: Novel Chemical Toolbox for Local Cancer Immunotherapy

Project Information

CHEMCHECK

Grant agreement ID: 679921

DOI 10.3030/679921

Project closed

EC signature date 21 June 2016

Start date 1 July 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

Publications

Peer reviewed articles (15)

Application of a Highly Selective Cathepsin S Two-step Activity-Based Probe in Multicolor Bio-Orthogonal Correlative Light-Electron Microscopy

Author(s): van Dalen, FJ, Bakkum, T, van Leeuwen, T, Groenewold, M, Deu, E, Koster, AJ, van Kasteren, SI, Verdoes, M.
Published in: Frontiers in Chemistry, Issue 8, 2020, Page(s) 628433, ISSN 2296-2646
Publisher: Frontiers Media S.A.
DOI: 10.3389/fchem.2020.628433

Distinct antigen uptake receptors route to the same storage compartments for cross-presentation in dendritic cells

Author(s): Ho, NI, Camps, MG, Garcia-Vallejo, JJ, Bos, E, Koster, AJ, Verdoes, M, van Kooyk, Y
Published in: Immunology, Issue 164(3), 2021, Page(s) 494-506, ISSN 0019-2805
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imm.13382

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

Author(s): Johan M. S. van der Schoot, Felix L. Fennemann, Michael Valente, Yusuf Dolen, Iris M. Hagemans, Anouk M. D. Becker, Camille M. Le Gall, Duco van Dalen, Alper Cevirgel, Jaco A. C. van Bruggen, Melanie Engelfriet, Tomislav Caval, Arthur E. H. Bentlage, Marieke F. Fransen, Maaike Nederend, Jeanette H. W. Leusen, Albert J. R. Heck, Gestur Vidarsson, Carl G. Figdor, Martijn Verdoes, Ferenc A. Scheeren
Published in: Science Advances, Issue 5/8, 2019, Page(s) eaaw1822, ISSN 2375-2548
Publisher: Custom publishers
DOI: 10.1126/sciadv.aaw1822

Semiflexible Immunobrushes Induce Enhanced T Cell Activation and Expansion

Author(s): Hammink, R, Weiden, J, Voerman, D, Popelier, C, Eggermont, LJ, Schluck, M, Figdor, CG, Verdoes, M
Published in: ACS Appl Meter Interfaces, Issue 13(14), 2021, Page(s) 16007-16018, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c21994

"Enhanced Antitumor Efficacy through an ""AND gate"" Reactive Oxygen-Species-Dependent pH-Responsive Nanomedicine Approach"

Author(s): Jager, E, Humajova, J, Dolen, Y, Kucka, J, Jager, A, Konefal, R, Pankrac, J, Pavlova, E, Heizer, T, Sefc, L, Hruby, M, Figdor, CG, Verdoes, M.
Published in: Adv Healthc Mater, 2021, Page(s) e2100304, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202100304

Autophagy regulates long-term cross-presentation by murine dendritic cells.

Author(s): Ho, NI, Camps, MGM, Verdoes, M, Munz, C, Ossendorp, F
Published in: Eur J Immunology, Issue 51(4), 2021, Page(s) 835-847, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048961

The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation

Author(s): Maksim V. Baranov, Frans Bianchi, Anastasiya Schirmacher, Melissa A.C. van Aart, Sjors Maassen, Elke M. Muntjewerff, Ilse Dingjan, Martin ter Beest, Martijn Verdoes, Samantha G.L. Keyser, Carolyn R. Bertozzi, Ulf Diederichsen, Geert van den Bogaart
Published in: iScience, Issue 11, 2019, Page(s) 160-177, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2018.12.015

Molecular Repolarisation of Tumour-Associated Macrophages

Author(s): Floris van Dalen, Marleen van Stevendaal, Felix Fennemann, Martijn Verdoes, Olga Ilina
Published in: Molecules, Issue 24/1, 2019, Page(s) 9, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24010009

Toll-like Receptor Agonist Conjugation: A Chemical Perspective

Author(s): Bob J. Ignacio, Tyler J. Albin, Aaron P. Esser-Kahn, Martijn Verdoes
Published in: Bioconjugate Chemistry, Issue 29/3, 2018, Page(s) 587-603, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.7b00808

Endolysosomal-Escape Nanovaccines through Adjuvant-Induced Tumor Antigen Assembly for Enhanced Effector CD8 + T Cell Activation

Author(s): Liping Qiu, Michael Valente, Yusuf Dolen, Eliezer Jäger, Martin ter Beest, Liyan Zheng, Carl G. Figdor, Martijn Verdoes
Published in: Small, Issue 14/15, 2018, Page(s) 1703539, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201703539

Synthetic Semiflexible and Bioactive Brushes

Author(s): Dion Voerman, Marjolein Schluck, Jorieke Weiden, Ben Joosten, Loek J. Eggermont, Tuur van den Eijnde, Bob Ignacio, Alessandra Cambi, Carl G. Figdor, Paul H. J. Kouwer, Martijn Verdoes, Roel Hammink, Alan E. Rowan
Published in: Biomacromolecules, Issue 20/7, 2019, Page(s) 2587-2597, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.9b00385

Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells

Author(s): Marjolein Schluck, Roel Hammink, Carl G. Figdor, Martijn Verdoes, Jorieke Weiden
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2019.00931

Attacking Tumors From All Sides: Personalized Multiplex Vaccines to Tackle Intratumor Heterogeneity

Author(s): Felix L. Fennemann, I. Jolanda M. de Vries, Carl G. Figdor, Martijn Verdoes
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2019.00824

Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents

Author(s): Hagemans IM, Wierstra PJ, Steuten K, Molkenboer-Kuenen JDM, van Dalen D, Ter Beest M, van der Schoot JMS, Ilina O, Gotthardt M, Figdor CG, Scheeren FA, Heskamp S,* Verdoes M.*
Published in: J Nanobiotechnology, Issue 20, 2022, Page(s) 64, ISSN 1477-3155
Publisher: BioMed Central
DOI: 10.1186/s12951-022-01272-5

Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots.

Author(s): Jorieke Weiden; Marjolein Schluck; Melina Ioannidis; Eric A. W. van Dinther; Mahboobeh Rezaeeyazdi; Fawad Omar; Juulke Steuten; Dion Voerman; Jurjen Tel; Mustafa Diken; Sidi A. Bencherif; Carl G. Figdor; Martijn Verdoes
Published in: ACS Biometar Sci Eng, Issue 1, 2021, Page(s) 5622-5632, ISSN 2373-9878
Publisher: ACS Publications
DOI: 10.1021/acsbiomaterials.0c01648

Other (2)

Dual site-specific chemoenzymatic antibody fragment conjugation using CRISPR-based hybridoma engineering

Author(s): Camille M. Le Gall, Johan M.S. van der Schoot, Iván Ramos-Tomillero, Melek Parlak Khalily, Floris J. van Dalen, Zacharias Wijfjes, Liyan Smeding, Duco van Dalen, Anna Cammarata, Kimberly M. Bonger, Carl G. Figdor, Ferenc A. Scheeren, Martijn Verdoes
Published in: 2020
Publisher: Biorxiv
DOI: 10.1101/2020.12.08.415182

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering.

Author(s): Johan M.S. van der Schoot, Felix L. Fennemann, Michael Valente, Yusuf Dolen, Iris M. Hagemans, Anouk M.D. Becker, Camille M. Le Gall, Duco van Dalen, Alper Cevirgel, J. Armando C. van Bruggen, Melanie Engelfriet, Marieke F. Fransen, Tomislav Caval, Arthur E.H. Bentlage, Maaike Nederend, Jeanette H.W. Leusen, Albert J.R. Heck, Gestur Vidarsson, Carl G. Figdor, Martijn Verdoes*, Ferenc A. Scheeren
Published in: 2019
Publisher: bioRxiv
DOI: 10.1101/551382