CHECKPOINTS IN CHECK: Novel Chemical Toolbox for Local Cancer Immunotherapy

Informazioni relative al progetto

CHEMCHECK

ID dell’accordo di sovvenzione: 679921

DOI 10.3030/679921

Progetto chiuso

Data della firma CE 21 Giugno 2016

Data di avvio 1 Luglio 2016

Data di completamento 31 Dicembre 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 500 000,00

Contributo UE € 1 500 000,00

Coordinato da

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

Pubblicazioni

Peer reviewed articles (15)

Application of a Highly Selective Cathepsin S Two-step Activity-Based Probe in Multicolor Bio-Orthogonal Correlative Light-Electron Microscopy

Autori: van Dalen, FJ, Bakkum, T, van Leeuwen, T, Groenewold, M, Deu, E, Koster, AJ, van Kasteren, SI, Verdoes, M.
Pubblicato in: Frontiers in Chemistry, Numero 8, 2020, Pagina/e 628433, ISSN 2296-2646
Editore: Frontiers Media S.A.
DOI: 10.3389/fchem.2020.628433

Distinct antigen uptake receptors route to the same storage compartments for cross-presentation in dendritic cells

Autori: Ho, NI, Camps, MG, Garcia-Vallejo, JJ, Bos, E, Koster, AJ, Verdoes, M, van Kooyk, Y
Pubblicato in: Immunology, Numero 164(3), 2021, Pagina/e 494-506, ISSN 0019-2805
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imm.13382

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

Autori: Johan M. S. van der Schoot, Felix L. Fennemann, Michael Valente, Yusuf Dolen, Iris M. Hagemans, Anouk M. D. Becker, Camille M. Le Gall, Duco van Dalen, Alper Cevirgel, Jaco A. C. van Bruggen, Melanie Engelfriet, Tomislav Caval, Arthur E. H. Bentlage, Marieke F. Fransen, Maaike Nederend, Jeanette H. W. Leusen, Albert J. R. Heck, Gestur Vidarsson, Carl G. Figdor, Martijn Verdoes, Ferenc A. Scheeren
Pubblicato in: Science Advances, Numero 5/8, 2019, Pagina/e eaaw1822, ISSN 2375-2548
Editore: Custom publishers
DOI: 10.1126/sciadv.aaw1822

Semiflexible Immunobrushes Induce Enhanced T Cell Activation and Expansion

Autori: Hammink, R, Weiden, J, Voerman, D, Popelier, C, Eggermont, LJ, Schluck, M, Figdor, CG, Verdoes, M
Pubblicato in: ACS Appl Meter Interfaces, Numero 13(14), 2021, Pagina/e 16007-16018, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.0c21994

"Enhanced Antitumor Efficacy through an ""AND gate"" Reactive Oxygen-Species-Dependent pH-Responsive Nanomedicine Approach"

Autori: Jager, E, Humajova, J, Dolen, Y, Kucka, J, Jager, A, Konefal, R, Pankrac, J, Pavlova, E, Heizer, T, Sefc, L, Hruby, M, Figdor, CG, Verdoes, M.
Pubblicato in: Adv Healthc Mater, 2021, Pagina/e e2100304, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/adhm.202100304

Autophagy regulates long-term cross-presentation by murine dendritic cells.

Autori: Ho, NI, Camps, MGM, Verdoes, M, Munz, C, Ossendorp, F
Pubblicato in: Eur J Immunology, Numero 51(4), 2021, Pagina/e 835-847, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048961

The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation

Autori: Maksim V. Baranov, Frans Bianchi, Anastasiya Schirmacher, Melissa A.C. van Aart, Sjors Maassen, Elke M. Muntjewerff, Ilse Dingjan, Martin ter Beest, Martijn Verdoes, Samantha G.L. Keyser, Carolyn R. Bertozzi, Ulf Diederichsen, Geert van den Bogaart
Pubblicato in: iScience, Numero 11, 2019, Pagina/e 160-177, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2018.12.015

Molecular Repolarisation of Tumour-Associated Macrophages

Autori: Floris van Dalen, Marleen van Stevendaal, Felix Fennemann, Martijn Verdoes, Olga Ilina
Pubblicato in: Molecules, Numero 24/1, 2019, Pagina/e 9, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24010009

Toll-like Receptor Agonist Conjugation: A Chemical Perspective

Autori: Bob J. Ignacio, Tyler J. Albin, Aaron P. Esser-Kahn, Martijn Verdoes
Pubblicato in: Bioconjugate Chemistry, Numero 29/3, 2018, Pagina/e 587-603, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.7b00808

Endolysosomal-Escape Nanovaccines through Adjuvant-Induced Tumor Antigen Assembly for Enhanced Effector CD8 + T Cell Activation

Autori: Liping Qiu, Michael Valente, Yusuf Dolen, Eliezer Jäger, Martin ter Beest, Liyan Zheng, Carl G. Figdor, Martijn Verdoes
Pubblicato in: Small, Numero 14/15, 2018, Pagina/e 1703539, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201703539

Synthetic Semiflexible and Bioactive Brushes

Autori: Dion Voerman, Marjolein Schluck, Jorieke Weiden, Ben Joosten, Loek J. Eggermont, Tuur van den Eijnde, Bob Ignacio, Alessandra Cambi, Carl G. Figdor, Paul H. J. Kouwer, Martijn Verdoes, Roel Hammink, Alan E. Rowan
Pubblicato in: Biomacromolecules, Numero 20/7, 2019, Pagina/e 2587-2597, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.9b00385

Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells

Autori: Marjolein Schluck, Roel Hammink, Carl G. Figdor, Martijn Verdoes, Jorieke Weiden
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2019.00931

Attacking Tumors From All Sides: Personalized Multiplex Vaccines to Tackle Intratumor Heterogeneity

Autori: Felix L. Fennemann, I. Jolanda M. de Vries, Carl G. Figdor, Martijn Verdoes
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2019.00824

Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents

Autori: Hagemans IM, Wierstra PJ, Steuten K, Molkenboer-Kuenen JDM, van Dalen D, Ter Beest M, van der Schoot JMS, Ilina O, Gotthardt M, Figdor CG, Scheeren FA, Heskamp S,* Verdoes M.*
Pubblicato in: J Nanobiotechnology, Numero 20, 2022, Pagina/e 64, ISSN 1477-3155
Editore: BioMed Central
DOI: 10.1186/s12951-022-01272-5

Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots.

Autori: Jorieke Weiden; Marjolein Schluck; Melina Ioannidis; Eric A. W. van Dinther; Mahboobeh Rezaeeyazdi; Fawad Omar; Juulke Steuten; Dion Voerman; Jurjen Tel; Mustafa Diken; Sidi A. Bencherif; Carl G. Figdor; Martijn Verdoes
Pubblicato in: ACS Biometar Sci Eng, Numero 1, 2021, Pagina/e 5622-5632, ISSN 2373-9878
Editore: ACS Publications
DOI: 10.1021/acsbiomaterials.0c01648

Other (2)

Dual site-specific chemoenzymatic antibody fragment conjugation using CRISPR-based hybridoma engineering

Autori: Camille M. Le Gall, Johan M.S. van der Schoot, Iván Ramos-Tomillero, Melek Parlak Khalily, Floris J. van Dalen, Zacharias Wijfjes, Liyan Smeding, Duco van Dalen, Anna Cammarata, Kimberly M. Bonger, Carl G. Figdor, Ferenc A. Scheeren, Martijn Verdoes
Pubblicato in: 2020
Editore: Biorxiv
DOI: 10.1101/2020.12.08.415182

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering.

Autori: Johan M.S. van der Schoot, Felix L. Fennemann, Michael Valente, Yusuf Dolen, Iris M. Hagemans, Anouk M.D. Becker, Camille M. Le Gall, Duco van Dalen, Alper Cevirgel, J. Armando C. van Bruggen, Melanie Engelfriet, Marieke F. Fransen, Tomislav Caval, Arthur E.H. Bentlage, Maaike Nederend, Jeanette H.W. Leusen, Albert J.R. Heck, Gestur Vidarsson, Carl G. Figdor, Martijn Verdoes*, Ferenc A. Scheeren
Pubblicato in: 2019
Editore: bioRxiv
DOI: 10.1101/551382