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Bile acid, immune-metabolism, lipid and glucose homeostasis

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Publications

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction

Author(s): Emilie Catry, Laure B Bindels, Anne Tailleux, Sophie Lestavel, Audrey M Neyrinck, Jean-François Goossens, Irina Lobysheva, Hubert Plovier, Ahmed Essaghir, Jean-Baptiste Demoulin, Caroline Bouzin, Barbara D Pachikian, Patrice D Cani, Bart Staels, Chantal Dessy, Nathalie M Delzenne
Published in: Gut, Issue 67/2, 2018, Page(s) 271-283, ISSN 0017-5749
DOI: 10.1136/gutjnl-2016-313316

The logic of transcriptional regulator recruitment architecture at cis -regulatory modules controlling liver functions

Author(s): Julie Dubois-Chevalier, Vanessa Dubois, Hélène Dehondt, Parisa Mazrooei, Claire Mazuy, Aurélien A. Sérandour, Céline Gheeraert, Penderia Guillaume, Eric Baugé, Bruno Derudas, Nathalie Hennuyer, Réjane Paumelle, Guillemette Marot, Jason S. Carroll, Mathieu Lupien, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Published in: Genome Research, Issue 27/6, 2017, Page(s) 985-996, ISSN 1088-9051
DOI: 10.1101/gr.217075.116

Alternative macrophages in atherosclerosis: not always protective!

Author(s): Benoit Pourcet, Bart Staels
Published in: Journal of Clinical Investigation, Issue 128/3, 2018, Page(s) 910-912, ISSN 0021-9738
DOI: 10.1172/JCI120123

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice

Author(s): Benoit Pourcet, Mathilde Zecchin, Lise Ferri, Justine Beauchamp, Sadicha Sitaula, Cyrielle Billon, Stéphane Delhaye, Jonathan Vanhoutte, Alicia Mayeuf-Louchart, Quentin Thorel, Joel T. Haas, Jérome Eeckhoute, David Dombrowicz, Christian Duhem, Alexis Boulinguiez, Steve Lancel, Yasmine Sebti, Thomas P. Burris, Bart Staels, Hélène M. Duez
Published in: Gastroenterology, Issue 154/5, 2018, Page(s) 1449-1464.e20, ISSN 0016-5085
DOI: 10.1053/j.gastro.2017.12.019

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

Author(s): Maheul Ploton, Claire Mazuy, Céline Gheeraert, Vanessa Dubois, Alexandre Berthier, Julie Dubois-Chevalier, Xavier Maréchal, Kadiombo Bantubungi, Hélène Diemer, Sarah Cianférani, Jean-Marc Strub, Audrey Helleboid-Chapman, Jérôme Eeckhoute, Bart Staels, Philippe Lefebvre
Published in: Journal of Hepatology, Issue 69/5, 2018, Page(s) 1099-1109, ISSN 0168-8278
DOI: 10.1016/j.jhep.2018.06.022

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

Author(s): Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, Florence Leroux, Catherine Piveteau, Loïc Belloy, Sophie Lestavel, Emmanuelle Vallez, Emilie Dorchies, Isabelle Duplan, Emmanuel Sevin, Maxime Culot, Fabien Gosselet, Rajaa Boulahjar, Adrien Herledan, Bart Staels, Benoit Deprez, Anne Tailleux, Julie Charton
Published in: Journal of Medicinal Chemistry, Issue 60/10, 2017, Page(s) 4185-4211, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.6b01873

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

Author(s): Oscar Chávez-Talavera, Anne Tailleux, Philippe Lefebvre, Bart Staels
Published in: Gastroenterology, Issue 152/7, 2017, Page(s) 1679-1694.e3, ISSN 0016-5085
DOI: 10.1053/j.gastro.2017.01.055