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Nucleases in homologous recombination: from basic principles to genome editing

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Publications

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

Author(s): Angelo Taglialatela, Silvia Alvarez, Giuseppe Leuzzi, Vincenzo Sannino, Lepakshi Ranjha, Jen-Wei Huang, Chioma Madubata, Roopesh Anand, Brynn Levy, Raul Rabadan, Petr Cejka, Vincenzo Costanzo, Alberto Ciccia
Published in: Molecular Cell, Issue 68/2, 2017, Page(s) 414-430.e8, ISSN 1097-2765
DOI: 10.1016/j.molcel.2017.09.036

Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes

Author(s): Lepakshi Ranjha, Sean M. Howard, Petr Cejka
Published in: Chromosoma, Issue 127/2, 2018, Page(s) 187-214, ISSN 0009-5915
DOI: 10.1007/s00412-017-0658-1

Stepwise 5′ DNA end-specific resection of DNA breaks by the Mre11-Rad50-Xrs2 and Sae2 nuclease ensemble

Author(s): Elda Cannavo, Giordano Reginato, Petr Cejka
Published in: Proceedings of the National Academy of Sciences, Issue 116/12, 2019, Page(s) 5505-5513, ISSN 0027-8424
DOI: 10.1073/pnas.1820157116

Regulatory control of DNA end resection by Sae2 phosphorylation

Author(s): Elda Cannavo, Dominic Johnson, Sara N. Andres, Vera M. Kissling, Julia K. Reinert, Valerie Garcia, Dorothy A. Erie, Daniel Hess, Nicolas H. Thomä, Radoslav I. Enchev, Matthias Peter, R. Scott Williams, Matt J. Neale, Petr Cejka
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-06417-5

Seeing is believing: DNA zipping promotes DNA repair

Author(s): Petr Cejka
Published in: Journal of Biological Chemistry, Issue 294/9, 2019, Page(s) 3321-3322, ISSN 0021-9258
DOI: 10.1074/jbc.h119.007814

NBS1 promotes the endonuclease activity of the MRE11‐RAD50 complex by sensing CtIP phosphorylation

Author(s): Roopesh Anand, Arti Jasrotia, Diana Bundschuh, Sean Michael Howard, Lepakshi Ranjha, Manuel Stucki, Petr Cejka
Published in: The EMBO Journal, Issue 38/7, 2019, Page(s) e101005, ISSN 0261-4189
DOI: 10.15252/embj.2018101005

BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

Author(s): Giuseppina D’Alessandro, Donna Rose Whelan, Sean Michael Howard, Valerio Vitelli, Xavier Renaudin, Marek Adamowicz, Fabio Iannelli, Corey Winston Jones-Weinert, MiYoung Lee, Valentina Matti, Wei Ting C. Lee, Michael John Morten, Ashok Raraakrishnan Venkitaraman, Petr Cejka, Eli Rothenberg, Fabrizio d’Adda di Fagagna
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-07799-2

Sumoylation regulates the stability and nuclease activity of Saccharomyces cerevisiae Dna2

Author(s): Lepakshi Ranjha, Maryna Levikova, Veronika Altmannova, Lumir Krejci, Petr Cejka
Published in: Communications Biology, Issue 2/1, 2019, ISSN 2399-3642
DOI: 10.1038/s42003-019-0428-0

Competing interaction partners modulate the activity of Sgs1 helicase during DNA end resection

Author(s): Kristina Kasaciunaite, Fergus Fettes, Maryna Levikova, Peter Daldrop, Roopesh Anand, Petr Cejka, Ralf Seidel
Published in: The EMBO Journal, Issue 38/13, 2019, ISSN 0261-4189
DOI: 10.15252/embj.2019101516

Methods to Study DNA End Resection I: Recombinant Protein Purification

Author(s): Roopesh Anand, Cosimo Pinto, Petr Cejka
Published in: Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Issue 600, 2018, Page(s) 25-66
DOI: 10.1016/bs.mie.2017.11.008

Methods to Study DNA End Resection II: Biochemical Reconstitution Assays

Author(s): Cosimo Pinto, Roopesh Anand, Petr Cejka
Published in: Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Issue 600, 2018, Page(s) 67-106
DOI: 10.1016/bs.mie.2017.11.009