Skip to main content

Targeting hypothalamic inflammation in obesity and diabetes

Searching for OpenAIRE data...

Publications

Gut hormone polyagonists for the treatment of type 2 diabetes

Author(s): Sara J. Brandt, Anna Götz, Matthias H. Tschöp, Timo D. Müller
Published in: Peptides, Issue 100, 2018, Page(s) 190-201, ISSN 0196-9781
DOI: 10.1016/j.peptides.2017.12.021

Gut-Brain Cross-Talk in Metabolic Control

Author(s): Christoffer Clemmensen, Timo D. Müller, Stephen C. Woods, Hans-Rudolf Berthoud, Randy J. Seeley, Matthias H. Tschöp
Published in: Cell, Issue 168/5, 2017, Page(s) 758-774, ISSN 0092-8674
DOI: 10.1016/j.cell.2017.01.025

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity

Author(s): Carmelo Quarta, Christoffer Clemmensen, Zhimeng Zhu, Bin Yang, Sini S. Joseph, Dominik Lutter, Chun-Xia Yi, Elisabeth Graf, Cristina García-Cáceres, Beata Legutko, Katrin Fischer, Robert Brommage, Philippe Zizzari, Bernardo S. Franklin, Martin Krueger, Marco Koch, Sabine Vettorazzi, Pengyun Li, Susanna M. Hofmann, Mostafa Bakhti, Aimée Bastidas-Ponce, Heiko Lickert, Tim M. Strom, Valerie Gailus
Published in: Cell Metabolism, Issue 26/4, 2017, Page(s) 620-632.e6, ISSN 1550-4131
DOI: 10.1016/j.cmet.2017.08.023

Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity

Author(s): Yuanqing Gao, Clarita Layritz, Beata Legutko, Thomas O. Eichmann, Elise Laperrousaz, Valentine S. Moullé, Celine Cruciani-Guglielmacci, Christophe Magnan, Serge Luquet, Stephen C. Woods, Robert H. Eckel, Chun-Xia Yi, Cristina Garcia-Caceres, Matthias H. Tschöp
Published in: Diabetes, Issue 66/10, 2017, Page(s) 2555-2563, ISSN 0012-1797
DOI: 10.2337/db16-1278

Therapeutic Potential of Targeting the Ghrelin Pathway

Author(s): Gustav Colldén, Matthias Tschöp, Timo Müller
Published in: International Journal of Molecular Sciences, Issue 18/4, 2017, Page(s) 798, ISSN 1422-0067
DOI: 10.3390/ijms18040798

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons

Author(s): Luis Varela, Shigetomo Suyama, Yan Huang, Marya Shanabrough, Matthias H. Tschöp, Xiao-Bing Gao, Frank J. Giordano, Tamas L. Horvath
Published in: Diabetes, Issue 66/6, 2017, Page(s) 1511-1520, ISSN 0012-1797
DOI: 10.2337/db16-1106

Ghrelin regulation of glucose metabolism

Author(s): Anne-Laure Poher, Matthias H. Tschöp, Timo D. Müller
Published in: Peptides, Issue 100, 2018, Page(s) 236-242, ISSN 0196-9781
DOI: 10.1016/j.peptides.2017.12.015

Emerging Poly-Agonists for Obesity and Type 2 Diabetes

Author(s): Maximilian Kleinert, Christoffer Clemmensen, Kerstin Stemmer, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp
Published in: Obesity, Issue 25/10, 2017, Page(s) 1647-1649, ISSN 1930-7381
DOI: 10.1002/oby.21932

TNFα drives mitochondrial stress in POMC neurons in obesity

Author(s): Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch, Matthias H. Tschöp
Published in: Nature Communications, Issue 8, 2017, Page(s) 15143, ISSN 2041-1723
DOI: 10.1038/ncomms15143

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

Author(s): Katrin Fischer, Henry H Ruiz, Kevin Jhun, Brian Finan, Douglas J Oberlin, Verena van der Heide, Anastasia V Kalinovich, Natasa Petrovic, Yochai Wolf, Christoffer Clemmensen, Andrew C Shin, Senad Divanovic, Frank Brombacher, Elke Glasmacher, Susanne Keipert, Martin Jastroch, Joachim Nagler, Karl-Werner Schramm, Dasa Medrikova, Gustav Collden, Stephen C Woods, Stephan Herzig, Dirk Homann, Steffen Ju
Published in: Nature Medicine, Issue 23/5, 2017, Page(s) 623-630, ISSN 1078-8956
DOI: 10.1038/nm.4316

Are peptide conjugates the golden therapy against obesity?

Author(s): S J Brandt, M Kleinert, M H Tschöp, T D Müller
Published in: Journal of Endocrinology, Issue 238/2, 2018, Page(s) R109-R119, ISSN 0022-0795
DOI: 10.1530/joe-18-0264

Dietary sugars, not lipids, drive hypothalamic inflammation

Author(s): Yuanqing Gao, Maximilian Bielohuby, Thomas Fleming, Gernot F. Grabner, Ewout Foppen, Wagner Bernhard, Mara Guzmán-Ruiz, Clarita Layritz, Beata Legutko, Erwin Zinser, Cristina García-Cáceres, Ruud M. Buijs, Stephen C. Woods, Andries Kalsbeek, Randy J. Seeley, Peter P. Nawroth, Martin Bidlingmaier, Matthias H. Tschöp, Chun-Xia Yi
Published in: Molecular Metabolism, Issue 6/8, 2017, Page(s) 897-908, ISSN 2212-8778
DOI: 10.1016/j.molmet.2017.06.008

Anti-Obesity Therapy: from Rainbow Pills to Polyagonists

Author(s): T. D. Müller, C. Clemmensen, B. Finan, R. D. DiMarchi, M. H. Tschöp
Published in: Pharmacological Reviews, Issue 70/4, 2018, Page(s) 712-746, ISSN 0031-6997
DOI: 10.1124/pr.117.014803

Peptide-based multi-agonists: a new paradigm in metabolic pharmacology

Author(s): S. J. Brandt, T. D. Müller, R. D. DiMarchi, M. H. Tschöp, K. Stemmer
Published in: Journal of Internal Medicine, Issue 284/6, 2018, Page(s) 581-602, ISSN 0954-6820
DOI: 10.1111/joim.12837

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Author(s): Carmelo Quarta, Alexandre Fisette, Yanjun Xu, Gustav Colldén, Beata Legutko, Yu-Ting Tseng, Alexander Reim, Michael Wierer, Maria Caterina De Rosa, Valentina Klaus, Rick Rausch, Vidhu V. Thaker, Elisabeth Graf, Tim M. Strom, Anne-Laure Poher, Tim Gruber, Ophélia Le Thuc, Alberto Cebrian-Serrano, Dhiraj Kabra, Luigi Bellocchio, Stephen C. Woods, Gert O. Pflugfelder, Rubén Nogueiras, Lori Zeltser
Published in: Nature Metabolism, Issue 1/2, 2019, Page(s) 222-235, ISSN 2522-5812
DOI: 10.1038/s42255-018-0028-1

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases

Author(s): Christoffer Clemmensen, Brian Finan, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp, Susanna M. Hofmann
Published in: Nature Reviews Endocrinology, Issue 15/2, 2019, Page(s) 90-104, ISSN 1759-5029
DOI: 10.1038/s41574-018-0118-x

Chronic d-serine supplementation impairs insulin secretion

Author(s): Lisa Suwandhi, Simone Hausmann, Alexander Braun, Tim Gruber, Silke S. Heinzmann, Eric J.C. Gálvez, Achim Buck, Beata Legutko, Andreas Israel, Annette Feuchtinger, Elizabeth Haythorne, Harald Staiger, Martin Heni, Hans-Ulrich Häring, Philippe Schmitt-Kopplin, Axel Walch, Cristina García Cáceres, Matthias H. Tschöp, Guy A. Rutter, Till Strowig, Martin Elsner, Siegfried Ussar
Published in: Molecular Metabolism, Issue 16, 2018, Page(s) 191-202, ISSN 2212-8778
DOI: 10.1016/j.molmet.2018.07.002

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

Author(s): Cristina García-Cáceres, Eglantine Balland, Vincent Prevot, Serge Luquet, Stephen C. Woods, Marco Koch, Tamas L. Horvath, Chun-Xia Yi, Julia A. Chowen, Alexei Verkhratsky, Alfonso Araque, Ingo Bechmann, Matthias H. Tschöp
Published in: Nature Neuroscience, Issue 22/1, 2019, Page(s) 7-14, ISSN 1097-6256
DOI: 10.1038/s41593-018-0286-y

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

Author(s): Cristina García-Cáceres, Carmelo Quarta, Luis Varela, Yuanqing Gao, Tim Gruber, Beata Legutko, Martin Jastroch, Pia Johansson, Jovica Ninkovic, Chun-Xia Yi, Ophelia Le Thuc, Klara Szigeti-Buck, Weikang Cai, Carola W. Meyer, Paul T. Pfluger, Ana M. Fernandez, Serge Luquet, Stephen C. Woods, Ignacio Torres-Alemán, C. Ronald Kahn, Magdalena Götz, Tamas L. Horvath, Matthias H. Tschöp
Published in: Cell, Issue 166/4, 2016, Page(s) 867-880, ISSN 0092-8674
DOI: 10.1016/j.cell.2016.07.028

Short-term cold exposure supports human Treg induction in vivo

Author(s): Maike Becker, Isabelle Serr, Victoria K. Salb, Verena B. Ott, Laura Mengel, Matthias Blüher, Benno Weigmann, Hans Hauner, Matthias H. Tschöp, Carolin Daniel
Published in: Molecular Metabolism, Issue 28, 2019, Page(s) 73-82, ISSN 2212-8778
DOI: 10.1016/j.molmet.2019.08.002

GLP-1/dexamethasone inhibits food reward without inducing mood and memory deficits in mice

Author(s): Léa Décarie-Spain, Alexandre Fisette, Zhimeng Zhu, Bin Yang, Richard D. DiMarchi, Matthias H. Tschöp, Brian Finan, Stephanie Fulton, Christoffer Clemmensen
Published in: Neuropharmacology, Issue 151, 2019, Page(s) 55-63, ISSN 0028-3908
DOI: 10.1016/j.neuropharm.2019.03.035

CNS-targeting pharmacological interventions for the metabolic syndrome

Author(s): Kerstin Stemmer, Timo D. Müller, Richard D. DiMarchi, Paul T. Pfluger, Matthias H. Tschöp
Published in: Journal of Clinical Investigation, Issue 129/10, 2019, Page(s) 4058-4071, ISSN 0021-9738
DOI: 10.1172/jci129195