Targeting hypothalamic inflammation in obesity and diabetes

Publications

Plasma proteome profiles treatment efficacy of incretin dual agonism in diet‐induced obese female and male mice

Author(s): Stephan Sachs, Lili Niu, Philipp Geyer, Sigrid Jall, Maximilian Kleinert, Annette Feuchtinger, Kerstin Stemmer, Markus Brielmeier, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp, Nicolai Wewer Albrechtsen, Matthias Mann, Timo D. Müller, Susanna M. Hofmann
Published in: Diabetes, Obesity and Metabolism, Issue 23/1, 2021, Page(s) 195-207, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.14215

Insights into incretin-based therapies for treatment of diabetic dyslipidemia

Author(s): Kerstin Stemmer, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp, Timo D. Müller
Published in: Advanced Drug Delivery Reviews, Issue 159, 2020, Page(s) 34-53, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2020.05.008

Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

Author(s): Maximilian Kleinert, Petra Kotzbeck, Thomas Altendorfer-Kroath, Thomas Birngruber, Matthias H. Tschöp, Christoffer Clemmensen
Published in: Molecular Metabolism, Issue 13, 2018, Page(s) 77-82, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.04.008

Short-term cold exposure supports human Treg induction in vivo

Author(s): Maike Becker, Isabelle Serr, Victoria K. Salb, Verena B. Ott, Laura Mengel, Matthias Blüher, Benno Weigmann, Hans Hauner, Matthias H. Tschöp, Carolin Daniel
Published in: Molecular Metabolism, Issue 28, 2019, Page(s) 73-82, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.08.002

Chip-Based Sensing of the Intercellular Transfer of Cell Surface Proteins: Regulation by the Metabolic State

Author(s): Müller, G. ; Tschöp, M.H. ; Müller, T.D.
Published in: Biomedicines, 2021, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines9101452

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice

Author(s): Aliluev, A. ; Tritschler, S. ; Sterr, M. ; Oppenländer, L. ; Hinterdobler, J. ; Greisle, T. ; Irmler, M. ; Beckers, J. ; Sun, N. ; Walch, A.K. ; Stemmer, K. ; Kindt, A. ; Krumsiek, J. ; Tschöp, M.H. ; Luecken, M. ; Theis, F.J. ; Lickert, H. ; Böttcher, A.
Published in: Nature metabolism, 2021, Page(s) 1202-1216, ISSN 2522-5812
Publisher: Springer
DOI: 10.1038/s42255-021-00458-9

Anti-obesity drug discovery: advances and challenges

Author(s): Timo D. Müller, Matthias Blüher, Matthias H. Tschöp & Richard D. DiMarchi
Published in: Nature Reviews - Drug Discovery, 2022, Page(s) 201-223, ISSN 1474-1776
Publisher: Nature Publishing Group
DOI: 10.1038/s41573-021-00337-8

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

Author(s): Aaron Novikoff, Shannon L. O'Brien, Miriam Bernecker, Gerald Grandl, Maximilian Kleinert, Patrick J. Knerr, Kerstin Stemmer, Martin Klingenspor, Anja Zeigerer, Richard DiMarchi, Matthias H. Tschöp, Brian Finan, Davide Calebiro, Timo D. Müller
Published in: Molecular Metabolism, Issue 49, 2021, Page(s) 101181, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2021.101181

The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

Author(s): Katrin Fischer, Anna Fenzl, Dianxin Liu, Kenneth A. Dyar, Maximilian Kleinert, Markus Brielmeier, Christoffer Clemmensen, Anna Fedl, Brian Finan, Andre Gessner, Martin Jastroch, Jianfeng Huang, Susanne Keipert, Martin Klingenspor, Jens C. Brüning, Manfred Kneilling, Florian C. Maier, Ahmed E. Othman, Bernd J. Pichler, Ines Pramme-Steinwachs, Stephan Sachs, Angelika Scheideler, Wolfgang M. Thaiss,
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16230-8

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

Author(s): Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff, Bin Yang, Felix Klingelhuber, Alex Harger, Mostafa Bakhti, Aimee Bastidas-Ponce, Eric Baugé, Jonathan E. Campbell, Megan Capozzi, Christoffer Clemmensen, Gustav Collden, Perla Cota, Jon Douros, Daniel J. Drucker, Barent DuBois, Annette Feuchtinger, Cristina Garcia-Caceres, Gerald Grandl, Nathalie Hennuyer, Stephan Herzig, Susanna M. Hofmann, Patric
Published in: Nature Metabolism, 2022, Page(s) 1071–1083, ISSN 2522-5812
Publisher: Springer
DOI: 10.1038/s42255-022-00617-6

Glucagon-like peptide 1 (GLP-1)

Author(s): T.D. Müller, B. Finan, S.R. Bloom, D. D'Alessio, D.J. Drucker, P.R. Flatt, A. Fritsche, F. Gribble, H.J. Grill, J.F. Habener, J.J. Holst, W. Langhans, J.J. Meier, M.A. Nauck, D. Perez-Tilve, A. Pocai, F. Reimann, D.A. Sandoval, T.W. Schwartz, R.J. Seeley, K. Stemmer, M. Tang-Christensen, S.C. Woods, R.D. DiMarchi, M.H. Tschöp
Published in: Molecular Metabolism, Issue 30, 2019, Page(s) 72-130, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.09.010

Revisiting energy expenditure: how to correct mouse metabolic rate for body mass

Author(s): Timo D. Müller, Martin Klingenspor, Matthias H. Tschöp
Published in: Nature metabolism, 2021, Page(s) 1134-1136, ISSN 2522-5812
Publisher: Springer
DOI: 10.1038/s42255-021-00451-2

Gut hormone polyagonists for the treatment of type 2 diabetes

Author(s): Sara J. Brandt, Anna Götz, Matthias H. Tschöp, Timo D. Müller
Published in: Peptides, Issue 100, 2018, Page(s) 190-201, ISSN 0196-9781
Publisher: Elsevier BV
DOI: 10.1016/j.peptides.2017.12.021

Gut-Brain Cross-Talk in Metabolic Control

Author(s): Christoffer Clemmensen, Timo D. Müller, Stephen C. Woods, Hans-Rudolf Berthoud, Randy J. Seeley, Matthias H. Tschöp
Published in: Cell, Issue 168/5, 2017, Page(s) 758-774, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.01.025

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity

Author(s): Carmelo Quarta, Christoffer Clemmensen, Zhimeng Zhu, Bin Yang, Sini S. Joseph, Dominik Lutter, Chun-Xia Yi, Elisabeth Graf, Cristina García-Cáceres, Beata Legutko, Katrin Fischer, Robert Brommage, Philippe Zizzari, Bernardo S. Franklin, Martin Krueger, Marco Koch, Sabine Vettorazzi, Pengyun Li, Susanna M. Hofmann, Mostafa Bakhti, Aimée Bastidas-Ponce, Heiko Lickert, Tim M. Strom, Valerie Gailus
Published in: Cell Metabolism, Issue 26/4, 2017, Page(s) 620-632.e6, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2017.08.023

Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity

Author(s): Yuanqing Gao, Clarita Layritz, Beata Legutko, Thomas O. Eichmann, Elise Laperrousaz, Valentine S. Moullé, Celine Cruciani-Guglielmacci, Christophe Magnan, Serge Luquet, Stephen C. Woods, Robert H. Eckel, Chun-Xia Yi, Cristina Garcia-Caceres, Matthias H. Tschöp
Published in: Diabetes, Issue 66/10, 2017, Page(s) 2555-2563, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db16-1278

Therapeutic Potential of Targeting the Ghrelin Pathway

Author(s): Gustav Colldén, Matthias Tschöp, Timo Müller
Published in: International Journal of Molecular Sciences, Issue 18/4, 2017, Page(s) 798, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18040798

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons

Author(s): Luis Varela, Shigetomo Suyama, Yan Huang, Marya Shanabrough, Matthias H. Tschöp, Xiao-Bing Gao, Frank J. Giordano, Tamas L. Horvath
Published in: Diabetes, Issue 66/6, 2017, Page(s) 1511-1520, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db16-1106

Ghrelin regulation of glucose metabolism

Author(s): Anne-Laure Poher, Matthias H. Tschöp, Timo D. Müller
Published in: Peptides, Issue 100, 2018, Page(s) 236-242, ISSN 0196-9781
Publisher: Elsevier BV
DOI: 10.1016/j.peptides.2017.12.015

Emerging Poly-Agonists for Obesity and Type 2 Diabetes

Author(s): Maximilian Kleinert, Christoffer Clemmensen, Kerstin Stemmer, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp
Published in: Obesity, Issue 25/10, 2017, Page(s) 1647-1649, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.21932

TNFα drives mitochondrial stress in POMC neurons in obesity

Author(s): Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch, Matthias H. Tschöp
Published in: Nature Communications, Issue 8, 2017, Page(s) 15143, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15143

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

Author(s): Katrin Fischer, Henry H Ruiz, Kevin Jhun, Brian Finan, Douglas J Oberlin, Verena van der Heide, Anastasia V Kalinovich, Natasa Petrovic, Yochai Wolf, Christoffer Clemmensen, Andrew C Shin, Senad Divanovic, Frank Brombacher, Elke Glasmacher, Susanne Keipert, Martin Jastroch, Joachim Nagler, Karl-Werner Schramm, Dasa Medrikova, Gustav Collden, Stephen C Woods, Stephan Herzig, Dirk Homann, Steffen Ju
Published in: Nature Medicine, Issue 23/5, 2017, Page(s) 623-630, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/nm.4316

Are peptide conjugates the golden therapy against obesity?

Author(s): S J Brandt, M Kleinert, M H Tschöp, T D Müller
Published in: Journal of Endocrinology, Issue 238/2, 2018, Page(s) R109-R119, ISSN 0022-0795
Publisher: Society for Endocrinology
DOI: 10.1530/joe-18-0264

Dietary sugars, not lipids, drive hypothalamic inflammation

Author(s): Yuanqing Gao, Maximilian Bielohuby, Thomas Fleming, Gernot F. Grabner, Ewout Foppen, Wagner Bernhard, Mara Guzmán-Ruiz, Clarita Layritz, Beata Legutko, Erwin Zinser, Cristina García-Cáceres, Ruud M. Buijs, Stephen C. Woods, Andries Kalsbeek, Randy J. Seeley, Peter P. Nawroth, Martin Bidlingmaier, Matthias H. Tschöp, Chun-Xia Yi
Published in: Molecular Metabolism, Issue 6/8, 2017, Page(s) 897-908, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.06.008

Anti-Obesity Therapy: from Rainbow Pills to Polyagonists

Author(s): T. D. Müller, C. Clemmensen, B. Finan, R. D. DiMarchi, M. H. Tschöp
Published in: Pharmacological Reviews, Issue 70/4, 2018, Page(s) 712-746, ISSN 0031-6997
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/pr.117.014803

Peptide-based multi-agonists: a new paradigm in metabolic pharmacology

Author(s): S. J. Brandt, T. D. Müller, R. D. DiMarchi, M. H. Tschöp, K. Stemmer
Published in: Journal of Internal Medicine, Issue 284/6, 2018, Page(s) 581-602, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.12837

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Author(s): Carmelo Quarta, Alexandre Fisette, Yanjun Xu, Gustav Colldén, Beata Legutko, Yu-Ting Tseng, Alexander Reim, Michael Wierer, Maria Caterina De Rosa, Valentina Klaus, Rick Rausch, Vidhu V. Thaker, Elisabeth Graf, Tim M. Strom, Anne-Laure Poher, Tim Gruber, Ophélia Le Thuc, Alberto Cebrian-Serrano, Dhiraj Kabra, Luigi Bellocchio, Stephen C. Woods, Gert O. Pflugfelder, Rubén Nogueiras, Lori Zeltser
Published in: Nature Metabolism, Issue 1/2, 2019, Page(s) 222-235, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-018-0028-1

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases

Author(s): Christoffer Clemmensen, Brian Finan, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp, Susanna M. Hofmann
Published in: Nature Reviews Endocrinology, Issue 15/2, 2019, Page(s) 90-104, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-018-0118-x

Chronic d-serine supplementation impairs insulin secretion

Author(s): Lisa Suwandhi, Simone Hausmann, Alexander Braun, Tim Gruber, Silke S. Heinzmann, Eric J.C. Gálvez, Achim Buck, Beata Legutko, Andreas Israel, Annette Feuchtinger, Elizabeth Haythorne, Harald Staiger, Martin Heni, Hans-Ulrich Häring, Philippe Schmitt-Kopplin, Axel Walch, Cristina García Cáceres, Matthias H. Tschöp, Guy A. Rutter, Till Strowig, Martin Elsner, Siegfried Ussar
Published in: Molecular Metabolism, Issue 16, 2018, Page(s) 191-202, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.07.002

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

Author(s): Cristina García-Cáceres, Eglantine Balland, Vincent Prevot, Serge Luquet, Stephen C. Woods, Marco Koch, Tamas L. Horvath, Chun-Xia Yi, Julia A. Chowen, Alexei Verkhratsky, Alfonso Araque, Ingo Bechmann, Matthias H. Tschöp
Published in: Nature Neuroscience, Issue 22/1, 2019, Page(s) 7-14, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0286-y

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

Author(s): Cristina García-Cáceres, Carmelo Quarta, Luis Varela, Yuanqing Gao, Tim Gruber, Beata Legutko, Martin Jastroch, Pia Johansson, Jovica Ninkovic, Chun-Xia Yi, Ophelia Le Thuc, Klara Szigeti-Buck, Weikang Cai, Carola W. Meyer, Paul T. Pfluger, Ana M. Fernandez, Serge Luquet, Stephen C. Woods, Ignacio Torres-Alemán, C. Ronald Kahn, Magdalena Götz, Tamas L. Horvath, Matthias H. Tschöp
Published in: Cell, Issue 166/4, 2016, Page(s) 867-880, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2016.07.028

GLP-1/dexamethasone inhibits food reward without inducing mood and memory deficits in mice

Author(s): Léa Décarie-Spain, Alexandre Fisette, Zhimeng Zhu, Bin Yang, Richard D. DiMarchi, Matthias H. Tschöp, Brian Finan, Stephanie Fulton, Christoffer Clemmensen
Published in: Neuropharmacology, Issue 151, 2019, Page(s) 55-63, ISSN 0028-3908
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2019.03.035

Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity

Author(s): Sigrid Jall, Meri De Angelis, Anne-Marie Lundsgaard, Andreas M. Fritzen, Trine S. Nicolaisen, Anders B. Klein, Aaron Novikoff, Stephan Sachs, Erik A. Richter, Bente Kiens, Karl-Werner Schramm, Matthias H. Tschöp, Kerstin Stemmer, Christoffer Clemmensen, Timo D. Müller, Maximilian Kleinert
Published in: Diabetologia, Issue 63/6, 2020, Page(s) 1236-1247, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05117-4

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.

Author(s): Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C.
Published in: Cell Metabolism, 2021, Page(s) 1155-1170, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.04.007

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Author(s): Qian Zhang, Challa Tenagne Delessa, Robert Augustin, Mostafa Bakhti, Gustav Colldén, Daniel J. Drucker, Annette Feuchtinger, Cristina Garcia Caceres, Gerald Grandl, Alexandra Harger, Stephan Herzig, Susanna Hofmann, Cassie Lynn Holleman, Martin Jastroch, Susanne Keipert, Maximilian Kleinert, Patrick J. Knerr, Konxhe Kulaj, Beata Legutko, Heiko Lickert, Xue Liu, Gerd Luippold, Dominik Lutter, Emil
Published in: Cell Metabolism, 2021, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.01.015

Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice

Author(s): Sigrid Jall, Brian Finan, Gustav Collden, Katrin Fischer, Xinzhong Dong, Matthias H. Tschöp, Timo D. Müller, Christoffer Clemmensen
Published in: Molecular Metabolism, Issue 23, 2019, Page(s) 75-81, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.02.011

Interaction of Full-Length Glycosylphosphatidylinositol-Anchored Proteins with Serum Proteins and Their Translocation to Cells In Vitro Depend on the (Pre-)Diabetic State in Rats and Humans

Author(s): Günter A Müller, Andreas Lechner, Matthias H Tschöp, Timo D Müller
Published in: Biomedicines, 2021, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines9030277

Hypothalamic astrocytes control systemic glucose metabolism and energy balance

Author(s): Herrera Moro Chao D, Kirchner MK, Pham C, Foppen E, Denis RGP, Castel J, Morel C, Montalban E, Hassouna R, Bui LC, Renault J, Mouffle C, García-Cáceres C, Tschöp MH, Li D, Martin C, Stern JE, Luquet SH
Published in: Cell Metabolism, Issue 15504131, 2022, Page(s) 1532-1547, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.09.002

Corrigendum to “Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice” [Molecular Metabolism 23 (2019) 75–81]

Author(s): Sigrid Jall, Brian Finan, Gustav Collden, Katrin Fischer, Xinzhong Dong, Matthias H. Tschöp, Timo D. Müller, Christoffer Clemmensen
Published in: Molecular Metabolism, Issue 30, 2019, Page(s) 264, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.11.002

Corrigendum to “Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice” [Molecular Metabolism 13 (2018) 77–82]

Author(s): Maximilian Kleinert, Petra Kotzbeck, Thomas Altendorfer-Kroath, Thomas Birngruber, Matthias H. Tschöp, Christoffer Clemmensen
Published in: Molecular Metabolism, Issue 30, 2019, Page(s) 265, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.11.001

CNS-targeting pharmacological interventions for the metabolic syndrome

Author(s): Kerstin Stemmer, Timo D. Müller, Richard D. DiMarchi, Paul T. Pfluger, Matthias H. Tschöp
Published in: Journal of Clinical Investigation, Issue 129/10, 2019, Page(s) 4058-4071, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci129195

Targeted pharmacological therapy restores β-cell function for diabetes remission

Author(s): Stephan Sachs, Aimée Bastidas-Ponce, Sophie Tritschler, Mostafa Bakhti, Anika Böttcher, Miguel A. Sánchez-Garrido, Marta Tarquis-Medina, Maximilian Kleinert, Katrin Fischer, Sigrid Jall, Alexandra Harger, Erik Bader, Sara Roscioni, Siegfried Ussar, Annette Feuchtinger, Burcak Yesildag, Aparna Neelakandhan, Christine B. Jensen, Marion Cornu, Bin Yang, Brian Finan, Richard D. DiMarchi, Matthias H
Published in: Nature Metabolism, Issue 2/2, 2020, Page(s) 192-209, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-020-0171-3

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