Targeting hypothalamic inflammation in obesity and diabetes

Informazioni relative al progetto

HypoFlam

ID dell’accordo di sovvenzione: 695054

DOI

10.3030/695054

Progetto chiuso

Data della firma CE 8 Agosto 2016

Data di avvio 1 Settembre 2016

Data di completamento 31 Agosto 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 402 280,00

Contributo UE

€ 2 402 280,00

Coordinato da

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (42)

Plasma proteome profiles treatment efficacy of incretin dual agonism in diet‐induced obese female and male mice

Autori: Stephan Sachs, Lili Niu, Philipp Geyer, Sigrid Jall, Maximilian Kleinert, Annette Feuchtinger, Kerstin Stemmer, Markus Brielmeier, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp, Nicolai Wewer Albrechtsen, Matthias Mann, Timo D. Müller, Susanna M. Hofmann
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 23/1, 2021, Pagina/e 195-207, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.14215

Insights into incretin-based therapies for treatment of diabetic dyslipidemia

Autori: Kerstin Stemmer, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp, Timo D. Müller
Pubblicato in: Advanced Drug Delivery Reviews, Numero 159, 2020, Pagina/e 34-53, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2020.05.008

Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

Autori: Maximilian Kleinert, Petra Kotzbeck, Thomas Altendorfer-Kroath, Thomas Birngruber, Matthias H. Tschöp, Christoffer Clemmensen
Pubblicato in: Molecular Metabolism, Numero 13, 2018, Pagina/e 77-82, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.04.008

Short-term cold exposure supports human Treg induction in vivo

Autori: Maike Becker, Isabelle Serr, Victoria K. Salb, Verena B. Ott, Laura Mengel, Matthias Blüher, Benno Weigmann, Hans Hauner, Matthias H. Tschöp, Carolin Daniel
Pubblicato in: Molecular Metabolism, Numero 28, 2019, Pagina/e 73-82, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.08.002

Chip-Based Sensing of the Intercellular Transfer of Cell Surface Proteins: Regulation by the Metabolic State

Autori: Müller, G. ; Tschöp, M.H. ; Müller, T.D.
Pubblicato in: Biomedicines, 2021, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9101452

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice

Autori: Aliluev, A. ; Tritschler, S. ; Sterr, M. ; Oppenländer, L. ; Hinterdobler, J. ; Greisle, T. ; Irmler, M. ; Beckers, J. ; Sun, N. ; Walch, A.K. ; Stemmer, K. ; Kindt, A. ; Krumsiek, J. ; Tschöp, M.H. ; Luecken, M. ; Theis, F.J. ; Lickert, H. ; Böttcher, A.
Pubblicato in: Nature metabolism, 2021, Pagina/e 1202-1216, ISSN 2522-5812
Editore: Springer
DOI: 10.1038/s42255-021-00458-9

Anti-obesity drug discovery: advances and challenges

Autori: Timo D. Müller, Matthias Blüher, Matthias H. Tschöp & Richard D. DiMarchi
Pubblicato in: Nature Reviews - Drug Discovery, 2022, Pagina/e 201-223, ISSN 1474-1776
Editore: Nature Publishing Group
DOI: 10.1038/s41573-021-00337-8

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

Autori: Aaron Novikoff, Shannon L. O'Brien, Miriam Bernecker, Gerald Grandl, Maximilian Kleinert, Patrick J. Knerr, Kerstin Stemmer, Martin Klingenspor, Anja Zeigerer, Richard DiMarchi, Matthias H. Tschöp, Brian Finan, Davide Calebiro, Timo D. Müller
Pubblicato in: Molecular Metabolism, Numero 49, 2021, Pagina/e 101181, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2021.101181

The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

Autori: Katrin Fischer, Anna Fenzl, Dianxin Liu, Kenneth A. Dyar, Maximilian Kleinert, Markus Brielmeier, Christoffer Clemmensen, Anna Fedl, Brian Finan, Andre Gessner, Martin Jastroch, Jianfeng Huang, Susanne Keipert, Martin Klingenspor, Jens C. Brüning, Manfred Kneilling, Florian C. Maier, Ahmed E. Othman, Bernd J. Pichler, Ines Pramme-Steinwachs, Stephan Sachs, Angelika Scheideler, Wolfgang M. Thaiss,
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-16230-8

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

Autori: Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff, Bin Yang, Felix Klingelhuber, Alex Harger, Mostafa Bakhti, Aimee Bastidas-Ponce, Eric Baugé, Jonathan E. Campbell, Megan Capozzi, Christoffer Clemmensen, Gustav Collden, Perla Cota, Jon Douros, Daniel J. Drucker, Barent DuBois, Annette Feuchtinger, Cristina Garcia-Caceres, Gerald Grandl, Nathalie Hennuyer, Stephan Herzig, Susanna M. Hofmann, Patric
Pubblicato in: Nature Metabolism, 2022, Pagina/e 1071–1083, ISSN 2522-5812
Editore: Springer
DOI: 10.1038/s42255-022-00617-6

Glucagon-like peptide 1 (GLP-1)

Autori: T.D. Müller, B. Finan, S.R. Bloom, D. D'Alessio, D.J. Drucker, P.R. Flatt, A. Fritsche, F. Gribble, H.J. Grill, J.F. Habener, J.J. Holst, W. Langhans, J.J. Meier, M.A. Nauck, D. Perez-Tilve, A. Pocai, F. Reimann, D.A. Sandoval, T.W. Schwartz, R.J. Seeley, K. Stemmer, M. Tang-Christensen, S.C. Woods, R.D. DiMarchi, M.H. Tschöp
Pubblicato in: Molecular Metabolism, Numero 30, 2019, Pagina/e 72-130, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.09.010

Revisiting energy expenditure: how to correct mouse metabolic rate for body mass

Autori: Timo D. Müller, Martin Klingenspor, Matthias H. Tschöp
Pubblicato in: Nature metabolism, 2021, Pagina/e 1134-1136, ISSN 2522-5812
Editore: Springer
DOI: 10.1038/s42255-021-00451-2

Gut hormone polyagonists for the treatment of type 2 diabetes

Autori: Sara J. Brandt, Anna Götz, Matthias H. Tschöp, Timo D. Müller
Pubblicato in: Peptides, Numero 100, 2018, Pagina/e 190-201, ISSN 0196-9781
Editore: Elsevier BV
DOI: 10.1016/j.peptides.2017.12.021

Gut-Brain Cross-Talk in Metabolic Control

Autori: Christoffer Clemmensen, Timo D. Müller, Stephen C. Woods, Hans-Rudolf Berthoud, Randy J. Seeley, Matthias H. Tschöp
Pubblicato in: Cell, Numero 168/5, 2017, Pagina/e 758-774, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2017.01.025

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity

Autori: Carmelo Quarta, Christoffer Clemmensen, Zhimeng Zhu, Bin Yang, Sini S. Joseph, Dominik Lutter, Chun-Xia Yi, Elisabeth Graf, Cristina García-Cáceres, Beata Legutko, Katrin Fischer, Robert Brommage, Philippe Zizzari, Bernardo S. Franklin, Martin Krueger, Marco Koch, Sabine Vettorazzi, Pengyun Li, Susanna M. Hofmann, Mostafa Bakhti, Aimée Bastidas-Ponce, Heiko Lickert, Tim M. Strom, Valerie Gailus
Pubblicato in: Cell Metabolism, Numero 26/4, 2017, Pagina/e 620-632.e6, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2017.08.023

Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity

Autori: Yuanqing Gao, Clarita Layritz, Beata Legutko, Thomas O. Eichmann, Elise Laperrousaz, Valentine S. Moullé, Celine Cruciani-Guglielmacci, Christophe Magnan, Serge Luquet, Stephen C. Woods, Robert H. Eckel, Chun-Xia Yi, Cristina Garcia-Caceres, Matthias H. Tschöp
Pubblicato in: Diabetes, Numero 66/10, 2017, Pagina/e 2555-2563, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db16-1278

Therapeutic Potential of Targeting the Ghrelin Pathway

Autori: Gustav Colldén, Matthias Tschöp, Timo Müller
Pubblicato in: International Journal of Molecular Sciences, Numero 18/4, 2017, Pagina/e 798, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18040798

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons

Autori: Luis Varela, Shigetomo Suyama, Yan Huang, Marya Shanabrough, Matthias H. Tschöp, Xiao-Bing Gao, Frank J. Giordano, Tamas L. Horvath
Pubblicato in: Diabetes, Numero 66/6, 2017, Pagina/e 1511-1520, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db16-1106

Ghrelin regulation of glucose metabolism

Autori: Anne-Laure Poher, Matthias H. Tschöp, Timo D. Müller
Pubblicato in: Peptides, Numero 100, 2018, Pagina/e 236-242, ISSN 0196-9781
Editore: Elsevier BV
DOI: 10.1016/j.peptides.2017.12.015

Emerging Poly-Agonists for Obesity and Type 2 Diabetes

Autori: Maximilian Kleinert, Christoffer Clemmensen, Kerstin Stemmer, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp
Pubblicato in: Obesity, Numero 25/10, 2017, Pagina/e 1647-1649, ISSN 1930-7381
Editore: Wiley-Blackwell
DOI: 10.1002/oby.21932

TNFα drives mitochondrial stress in POMC neurons in obesity

Autori: Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch, Matthias H. Tschöp
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 15143, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms15143

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

Autori: Katrin Fischer, Henry H Ruiz, Kevin Jhun, Brian Finan, Douglas J Oberlin, Verena van der Heide, Anastasia V Kalinovich, Natasa Petrovic, Yochai Wolf, Christoffer Clemmensen, Andrew C Shin, Senad Divanovic, Frank Brombacher, Elke Glasmacher, Susanne Keipert, Martin Jastroch, Joachim Nagler, Karl-Werner Schramm, Dasa Medrikova, Gustav Collden, Stephen C Woods, Stephan Herzig, Dirk Homann, Steffen Ju
Pubblicato in: Nature Medicine, Numero 23/5, 2017, Pagina/e 623-630, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/nm.4316

Are peptide conjugates the golden therapy against obesity?

Autori: S J Brandt, M Kleinert, M H Tschöp, T D Müller
Pubblicato in: Journal of Endocrinology, Numero 238/2, 2018, Pagina/e R109-R119, ISSN 0022-0795
Editore: Society for Endocrinology
DOI: 10.1530/joe-18-0264

Dietary sugars, not lipids, drive hypothalamic inflammation

Autori: Yuanqing Gao, Maximilian Bielohuby, Thomas Fleming, Gernot F. Grabner, Ewout Foppen, Wagner Bernhard, Mara Guzmán-Ruiz, Clarita Layritz, Beata Legutko, Erwin Zinser, Cristina García-Cáceres, Ruud M. Buijs, Stephen C. Woods, Andries Kalsbeek, Randy J. Seeley, Peter P. Nawroth, Martin Bidlingmaier, Matthias H. Tschöp, Chun-Xia Yi
Pubblicato in: Molecular Metabolism, Numero 6/8, 2017, Pagina/e 897-908, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.06.008

Anti-Obesity Therapy: from Rainbow Pills to Polyagonists

Autori: T. D. Müller, C. Clemmensen, B. Finan, R. D. DiMarchi, M. H. Tschöp
Pubblicato in: Pharmacological Reviews, Numero 70/4, 2018, Pagina/e 712-746, ISSN 0031-6997
Editore: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/pr.117.014803

Peptide-based multi-agonists: a new paradigm in metabolic pharmacology

Autori: S. J. Brandt, T. D. Müller, R. D. DiMarchi, M. H. Tschöp, K. Stemmer
Pubblicato in: Journal of Internal Medicine, Numero 284/6, 2018, Pagina/e 581-602, ISSN 0954-6820
Editore: Blackwell Publishing Inc.
DOI: 10.1111/joim.12837

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Autori: Carmelo Quarta, Alexandre Fisette, Yanjun Xu, Gustav Colldén, Beata Legutko, Yu-Ting Tseng, Alexander Reim, Michael Wierer, Maria Caterina De Rosa, Valentina Klaus, Rick Rausch, Vidhu V. Thaker, Elisabeth Graf, Tim M. Strom, Anne-Laure Poher, Tim Gruber, Ophélia Le Thuc, Alberto Cebrian-Serrano, Dhiraj Kabra, Luigi Bellocchio, Stephen C. Woods, Gert O. Pflugfelder, Rubén Nogueiras, Lori Zeltser
Pubblicato in: Nature Metabolism, Numero 1/2, 2019, Pagina/e 222-235, ISSN 2522-5812
Editore: Nature Publishing Group
DOI: 10.1038/s42255-018-0028-1

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases

Autori: Christoffer Clemmensen, Brian Finan, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp, Susanna M. Hofmann
Pubblicato in: Nature Reviews Endocrinology, Numero 15/2, 2019, Pagina/e 90-104, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-018-0118-x

Chronic d-serine supplementation impairs insulin secretion

Autori: Lisa Suwandhi, Simone Hausmann, Alexander Braun, Tim Gruber, Silke S. Heinzmann, Eric J.C. Gálvez, Achim Buck, Beata Legutko, Andreas Israel, Annette Feuchtinger, Elizabeth Haythorne, Harald Staiger, Martin Heni, Hans-Ulrich Häring, Philippe Schmitt-Kopplin, Axel Walch, Cristina García Cáceres, Matthias H. Tschöp, Guy A. Rutter, Till Strowig, Martin Elsner, Siegfried Ussar
Pubblicato in: Molecular Metabolism, Numero 16, 2018, Pagina/e 191-202, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.07.002

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

Autori: Cristina García-Cáceres, Eglantine Balland, Vincent Prevot, Serge Luquet, Stephen C. Woods, Marco Koch, Tamas L. Horvath, Chun-Xia Yi, Julia A. Chowen, Alexei Verkhratsky, Alfonso Araque, Ingo Bechmann, Matthias H. Tschöp
Pubblicato in: Nature Neuroscience, Numero 22/1, 2019, Pagina/e 7-14, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-018-0286-y

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

Autori: Cristina García-Cáceres, Carmelo Quarta, Luis Varela, Yuanqing Gao, Tim Gruber, Beata Legutko, Martin Jastroch, Pia Johansson, Jovica Ninkovic, Chun-Xia Yi, Ophelia Le Thuc, Klara Szigeti-Buck, Weikang Cai, Carola W. Meyer, Paul T. Pfluger, Ana M. Fernandez, Serge Luquet, Stephen C. Woods, Ignacio Torres-Alemán, C. Ronald Kahn, Magdalena Götz, Tamas L. Horvath, Matthias H. Tschöp
Pubblicato in: Cell, Numero 166/4, 2016, Pagina/e 867-880, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2016.07.028

GLP-1/dexamethasone inhibits food reward without inducing mood and memory deficits in mice

Autori: Léa Décarie-Spain, Alexandre Fisette, Zhimeng Zhu, Bin Yang, Richard D. DiMarchi, Matthias H. Tschöp, Brian Finan, Stephanie Fulton, Christoffer Clemmensen
Pubblicato in: Neuropharmacology, Numero 151, 2019, Pagina/e 55-63, ISSN 0028-3908
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2019.03.035

Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity

Autori: Sigrid Jall, Meri De Angelis, Anne-Marie Lundsgaard, Andreas M. Fritzen, Trine S. Nicolaisen, Anders B. Klein, Aaron Novikoff, Stephan Sachs, Erik A. Richter, Bente Kiens, Karl-Werner Schramm, Matthias H. Tschöp, Kerstin Stemmer, Christoffer Clemmensen, Timo D. Müller, Maximilian Kleinert
Pubblicato in: Diabetologia, Numero 63/6, 2020, Pagina/e 1236-1247, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05117-4

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.

Autori: Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C.
Pubblicato in: Cell Metabolism, 2021, Pagina/e 1155-1170, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2021.04.007

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Autori: Qian Zhang, Challa Tenagne Delessa, Robert Augustin, Mostafa Bakhti, Gustav Colldén, Daniel J. Drucker, Annette Feuchtinger, Cristina Garcia Caceres, Gerald Grandl, Alexandra Harger, Stephan Herzig, Susanna Hofmann, Cassie Lynn Holleman, Martin Jastroch, Susanne Keipert, Maximilian Kleinert, Patrick J. Knerr, Konxhe Kulaj, Beata Legutko, Heiko Lickert, Xue Liu, Gerd Luippold, Dominik Lutter, Emil
Pubblicato in: Cell Metabolism, 2021, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2021.01.015

Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice

Autori: Sigrid Jall, Brian Finan, Gustav Collden, Katrin Fischer, Xinzhong Dong, Matthias H. Tschöp, Timo D. Müller, Christoffer Clemmensen
Pubblicato in: Molecular Metabolism, Numero 23, 2019, Pagina/e 75-81, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.02.011

Interaction of Full-Length Glycosylphosphatidylinositol-Anchored Proteins with Serum Proteins and Their Translocation to Cells In Vitro Depend on the (Pre-)Diabetic State in Rats and Humans

Autori: Günter A Müller, Andreas Lechner, Matthias H Tschöp, Timo D Müller
Pubblicato in: Biomedicines, 2021, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9030277

Hypothalamic astrocytes control systemic glucose metabolism and energy balance

Autori: Herrera Moro Chao D, Kirchner MK, Pham C, Foppen E, Denis RGP, Castel J, Morel C, Montalban E, Hassouna R, Bui LC, Renault J, Mouffle C, García-Cáceres C, Tschöp MH, Li D, Martin C, Stern JE, Luquet SH
Pubblicato in: Cell Metabolism, 2022, Pagina/e 1532-1547, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2022.09.002

Corrigendum to “Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice” [Molecular Metabolism 23 (2019) 75–81]

Autori: Sigrid Jall, Brian Finan, Gustav Collden, Katrin Fischer, Xinzhong Dong, Matthias H. Tschöp, Timo D. Müller, Christoffer Clemmensen
Pubblicato in: Molecular Metabolism, Numero 30, 2019, Pagina/e 264, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.11.002

Corrigendum to “Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice” [Molecular Metabolism 13 (2018) 77–82]

Autori: Maximilian Kleinert, Petra Kotzbeck, Thomas Altendorfer-Kroath, Thomas Birngruber, Matthias H. Tschöp, Christoffer Clemmensen
Pubblicato in: Molecular Metabolism, Numero 30, 2019, Pagina/e 265, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.11.001

CNS-targeting pharmacological interventions for the metabolic syndrome

Autori: Kerstin Stemmer, Timo D. Müller, Richard D. DiMarchi, Paul T. Pfluger, Matthias H. Tschöp
Pubblicato in: Journal of Clinical Investigation, Numero 129/10, 2019, Pagina/e 4058-4071, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci129195

Targeted pharmacological therapy restores β-cell function for diabetes remission

Autori: Stephan Sachs, Aimée Bastidas-Ponce, Sophie Tritschler, Mostafa Bakhti, Anika Böttcher, Miguel A. Sánchez-Garrido, Marta Tarquis-Medina, Maximilian Kleinert, Katrin Fischer, Sigrid Jall, Alexandra Harger, Erik Bader, Sara Roscioni, Siegfried Ussar, Annette Feuchtinger, Burcak Yesildag, Aparna Neelakandhan, Christine B. Jensen, Marion Cornu, Bin Yang, Brian Finan, Richard D. DiMarchi, Matthias H
Pubblicato in: Nature Metabolism, Numero 2/2, 2020, Pagina/e 192-209, ISSN 2522-5812
Editore: Nature Publishing Group
DOI: 10.1038/s42255-020-0171-3