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Functional Genomics of the Lysosome

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Publications

A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome

Author(s): Gennaro Napolitano, Chiara Di Malta, Alessandra Esposito, Mariana E.G. de Araujo, Salvatore Pece, Giovanni Bertalot, Maria Matarese, Valerio Benedetti, Angela Zampelli, Taras Stasyk, Diletta Siciliano, Alessandro Venuta, Marcella Cesana, Claudia Vilardo, Edoardo Nusco, Jlenia Monfregola, Alessia Calcagni, Pier Paolo Di Fiore, Lukas A. Huber, Andrea Ballabio
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2444-0

TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway

Author(s): A. Scotto Rosato; Sandro Montefusco; Chiara Soldati; S. Di Paola; A. Capuozzo; Jlenia Monfregola; Elena V. Polishchuk; Angelo Amabile; Christian Grimm; Angelo Lombardo; M. A. De Matteis; Andrea Ballabio; Diego L. Medina
Published in: Nature Communications, 1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13572-w

TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages

Author(s): Ev-Marie Schuster, Maximilian W. Epple, Katharina M. Glaser, Michael Mihlan, Kerstin Lucht,1 Julia A. Zimmermann, Anna Bremser, Aikaterini Polyzou, Nadine Obier, Nina Cabezas-Wallscheid, Eirini Trompouki, Andrea Ballabio, Jörg Vogel, Joerg M. Buescher, Alexander J. Westermann and Angelika S. Rambold
Published in: Nature Metabolism, 2022, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-022-00605-w

The rapidly evolving view of lysosomal storage diseases

Author(s): Giancarlo Parenti; Diego L. Medina; Andrea Ballabio
Published in: EMBO Molecular Medicine, 1, 2021, ISSN 1757-4684
Publisher: Wiley
DOI: 10.15252/emmm.202012836

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

Author(s): Rosa Puertollano, Shawn M Ferguson, James Brugarolas, Andrea Ballabio
Published in: The EMBO Journal, 2018, Page(s) e98804, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201798804

mTOR-dependent phosphorylation controls TFEB nuclear export

Author(s): Gennaro Napolitano, Alessandra Esposito, Heejun Choi, Maria Matarese, Valerio Benedetti, Chiara Di Malta, Jlenia Monfregola, Diego Luis Medina, Jennifer Lippincott-Schwartz, Andrea Ballabio
Published in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05862-6

TFEB controls vascular development by regulating the proliferation of endothelial cells

Author(s): Gabriella Doronzo, Elena Astanina, Davide Corà, Giulia Chiabotto, Valentina Comunanza, Alessio Noghero, Francesco Neri, Alberto Puliafito, Luca Primo, Carmine Spampanato, Carmine Settembre, Andrea Ballabio, Giovanni Camussi, Salvatore Oliviero, Federico Bussolino
Published in: The EMBO Journal, 38/3, 2019, Page(s) e98250, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201798250

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

Author(s): Chiara Di Malta, Diletta Siciliano, Alessia Calcagni, Jlenia Monfregola, Simona Punzi, Nunzia Pastore, Andrea N. Eastes, Oliver Davis, Rossella De Cegli, Angela Zampelli, Luca G. Di Giovannantonio, Edoardo Nusco, Nick Platt, Alessandro Guida, Margret Helga Ogmundsdottir, Luisa Lanfrancone, Rushika M. Perera, Roberto Zoncu, Pier Giuseppe Pelicci, Carmine Settembre, Andrea Ballabio
Published in: Science, 356/6343, 2017, Page(s) 1188-1192, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aag2553

GADD34 is a modulator of autophagy during starvation

Author(s): Gennaro Gambardella; Leopoldo Staiano; Maria Nicoletta Moretti; Rossella De Cegli; Luca Fagnocchi; Giuseppe Di Tullio; Sara Polletti; Clarissa Braccia; Andrea Armirotti; Alessio Zippo; Andrea Ballabio; Andrea Ballabio; Maria Antonietta De Matteis; Diego di Bernardo
Published in: SCIENCE ADVANCES, 1, 2020, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abb0205