Objective
Cardiovascular (CV) disease is a main cause of death worldwide. During adulthood, ischemic heart disease leads to heart failure and perinatally, congenital heart defects are found in over 20% of deaths. Moreover, genetic or epigenetic factors altering development can have an impact much later in life. These facts underscore the need of a better understanding of the genetic and environmental factors that influence CV development. An important way to increase our knowledge is by visualizing cardiac development in vivo. Recent advance in microscopy allows monitoring CV development at a cellular level in organisms such as the zebrafish model. Particularly revolutionary has been the development of light sheet microscopy (LSM). We want to further exploit LSM for in vivo manipulation of cells in the embryonic zebrafish heart and measure with high precision biophysical parameters, by introducing novel features to LSM such as optical tweezers. High throughput cardiac imaging protocols for zebrafish larvae suitable for screenings will be set up. We will develop softwares to enhance resolution of acquisition, large dataset handling and image-processing. The aim is to generate a toolbox to be implemented into existing software packages allowing a complete modeling of zebrafish cardiac morphogenesis. We will adapt LSM for adult zebrafish hearts to study cardiac regeneration and mouse heart development at cellular resolution. Each Early Stage Researchers (ESRs) will develop their own technology to solve a biological problem at the frontier of knowledge. ESRs will receive multidisciplinary (CV development, physics, biocomputing, bioimaging) as well as intersectorial (academic research, SMEs, large companies) training and will achieve unique skills on microscopy, in-vivo imaging and image analysis allowing them to interrogate questions on cardiac development and regeneration. Their profile will be at the interface of a bioengineer and a life science researcher filling a currently existing gap on the market.
Fields of science
Programme(s)
Funding Scheme
MSCA-ITN-EID - European Industrial DoctoratesCoordinator
28029 Madrid
Spain
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Participants (7)
Participation ended
75179 Pforzheim
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
35578 Wetzlar
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67404 Illkirch Graffenstaden
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75794 Paris
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3012 Bern
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28050 Madrid
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75179 Pforzheim
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partners (7)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
28049 Madrid
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
28903 Getafe (Madrid)
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
67081 Strasbourg
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
28006 Madrid
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1920 Martigny
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Brussels
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
91128 Palaiseau Cedex
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