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Mapping metabolic regulators at a genome-scale to switch bacteria from growth to overproduction of chemicals

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Systematic analysis of in-source modifications of primary metabolites during flow-injection time-of-flight mass spectrometry

Author(s): Farke N, Schramm T, Verhülsdonk A, Rapp J, Link H
Published in: Analytical Biochemistry, 2023, ISSN 1096-0309
Publisher: Elsevier
DOI: 10.1016/j.ab.2023.115036

Multi-omics Analysis of CRISPRi-Knockdowns Identifies Mechanisms that Buffer Decreases of Enzymes in E. coli Metabolism

Author(s): Stefano Donati, Michelle Kuntz, Vanessa Pahl, Niklas Farke, Dominik Beuter, Timo Glatter, José Vicente Gomes-Filho, Lennart Randau, Chun-Ying Wang, Hannes Link
Published in: Cell Systems, 12, 2020, Page(s) 1-12, ISSN 2405-4712
Publisher: Cell Systems
DOI: 10.1016/j.cels.2020.10.011

Allosteric Feedback Inhibition Enables Robust Amino Acid Biosynthesis in E. coli by Enforcing Enzyme Overabundance

Author(s): Timur Sander, Niklas Farke, Christoph Diehl, Michelle Kuntz, Timo Glatter, Hannes Link
Published in: Cell Systems, 8/1, 2019, Page(s) 66-75.e8, ISSN 2405-4712
Publisher: Elsevier
DOI: 10.1016/j.cels.2018.12.005

Broadening the Scope of Enforced ATP Wasting as a Tool for Metabolic Engineering in Escherichia coli

Author(s): Simon Boecker, Ahmed Zahoor, Thorben Schramm, Hannes Link, Steffen Klamt
Published in: Biotechnology Journal, 2019, Page(s) 1800438, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800438

Systematic identification of metabolites controlling gene expression in E. coli

Author(s): Martin Lempp, Niklas Farke, Michelle Kuntz, Sven Andreas Freibert, Roland Lill, Hannes Link
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12474-1

High-throughput enrichment of temperature-sensitive argininosuccinate synthetase for two-stage citrulline production in E. coli

Author(s): Thorben Schramm, Martin Lempp, Dominik Beuter, Silvia González Sierra, Timo Glatter, Hannes Link
Published in: Metabolic Engineering, 60, 2020, Page(s) 14-24, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/j.ymben.2020.03.004

Homeostasis of the biosynthetic E. coli metabolome

Author(s): Radoš D, Donati S, Lempp M, Rapp J, Link H
Published in: iScience, 2022, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2022.104503