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Mapping metabolic regulators at a genome-scale to switch bacteria from growth to overproduction of chemicals

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Publications

Multi-omics Analysis of CRISPRi-Knockdowns Identifies Mechanisms that Buffer Decreases of Enzymes in E. coli Metabolism

Author(s): Stefano Donati, Michelle Kuntz, Vanessa Pahl, Niklas Farke, Dominik Beuter, Timo Glatter, José Vicente Gomes-Filho, Lennart Randau, Chun-Ying Wang, Hannes Link
Published in: Cell Systems, Issue 12, 2020, Page(s) 1-12, ISSN 2405-4712
DOI: 10.1016/j.cels.2020.10.011

Allosteric Feedback Inhibition Enables Robust Amino Acid Biosynthesis in E. coli by Enforcing Enzyme Overabundance

Author(s): Timur Sander, Niklas Farke, Christoph Diehl, Michelle Kuntz, Timo Glatter, Hannes Link
Published in: Cell Systems, Issue 8/1, 2019, Page(s) 66-75.e8, ISSN 2405-4712
DOI: 10.1016/j.cels.2018.12.005

Broadening the Scope of Enforced ATP Wasting as a Tool for Metabolic Engineering in Escherichia coli

Author(s): Simon Boecker, Ahmed Zahoor, Thorben Schramm, Hannes Link, Steffen Klamt
Published in: Biotechnology Journal, 2019, Page(s) 1800438, ISSN 1860-6768
DOI: 10.1002/biot.201800438

Systematic identification of metabolites controlling gene expression in E. coli

Author(s): Martin Lempp, Niklas Farke, Michelle Kuntz, Sven Andreas Freibert, Roland Lill, Hannes Link
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-12474-1

High-throughput enrichment of temperature-sensitive argininosuccinate synthetase for two-stage citrulline production in E. coli

Author(s): Thorben Schramm, Martin Lempp, Dominik Beuter, Silvia González Sierra, Timo Glatter, Hannes Link
Published in: Metabolic Engineering, Issue 60, 2020, Page(s) 14-24, ISSN 1096-7176
DOI: 10.1016/j.ymben.2020.03.004