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Adaptive Bio-electronics for Chronic Cardiorespiratory Disease

Objective

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients’ life and increase quality of life.

Coordinator

UNIVERSITY OF BATH
Net EU contribution
€ 1 548 936,25
Address
Claverton Down
BA2 7AY Bath
United Kingdom

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Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bath and North East Somerset, North Somerset and South Gloucestershire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (7)

UNIVERSITY OF BRISTOL

Participation ended

United Kingdom
Net EU contribution
€ 431 668,75
Address
Beacon House Queens Road
BS8 1QU Bristol

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Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAT ZURICH
Switzerland
Net EU contribution
€ 833 367,50
Address
Ramistrasse 71
8006 Zurich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MICROCHIP TECHNOLOGY CALDICOT LIMITED
United Kingdom
Net EU contribution
€ 403 125,00
Address
Phase 2 Castlegate Business Park
NP26 5YW Gwent

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Region
Wales East Wales Monmouthshire and Newport
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MEDTRONIC BAKKEN RESEARCH CENTER B.V.
Netherlands
Net EU contribution
€ 550 000,00
Address
Endepolsdomein 5
6229GW Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 584 375,00
Address
Spitalgasse 23
1090 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 490 625,00
Address
Heidelberglaan 100
3584 CX Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Czechia
Net EU contribution
€ 102 250,00
Address
Pekarska 53
656 91 Brno

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Region
Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00