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Adaptive Bio-electronics for Chronic Cardiorespiratory Disease

Objective

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients’ life and increase quality of life.

Field of science

  • /natural sciences/computer and information sciences/artificial intelligence/computational intelligence
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants

Call for proposal

FETPROACT-2016
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITY OF BATH
Address
Claverton Down
BA2 7AY Bath
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 548 936,25

Participants (7)

UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 431 668,75
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 833 367,50
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
MICROCHIP TECHNOLOGY CALDICOT LIMITED
United Kingdom
EU contribution
€ 403 125
Address
Phase 2 Castlegate Business Park
NP26 5YW Gwent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDTRONIC BAKKEN RESEARCH CENTER B.V.
Netherlands
EU contribution
€ 550 000
Address
Endepolsdomein 5
6229GW Maastricht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 584 375
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 490 625
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Czechia
EU contribution
€ 102 250
Address
Pekarska 53
656 91 Brno
Activity type
Higher or Secondary Education Establishments