CORDIS
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CORDIS

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Adaptive Bio-electronics for Chronic Cardiorespiratory Disease

Adaptive Bio-electronics for Chronic Cardiorespiratory Disease

Objective

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients’ life and increase quality of life.
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Coordinator

UNIVERSITY OF BATH

Address

Claverton Down
Ba2 7ay Bath

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 548 936,25

Participants (7)

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UNIVERSITY OF BRISTOL

United Kingdom

EU Contribution

€ 431 668,75

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 833 367,50

MICROSEMI SEMICONDUCTOR LIMITED

United Kingdom

EU Contribution

€ 403 125

MEDTRONIC BAKKEN RESEARCH CENTER B.V.

Netherlands

EU Contribution

€ 550 000

MEDIZINISCHE UNIVERSITAET WIEN

Austria

EU Contribution

€ 584 375

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 490 625

FAKULTNI NEMOCNICE U SV. ANNY V BRNE

Czechia

EU Contribution

€ 102 250

Project information

Grant agreement ID: 732170

Status

Ongoing project

  • Start date

    1 January 2017

  • End date

    31 December 2021

Funded under:

H2020-EU.1.2.2.

  • Overall budget:

    € 4 944 347,50

  • EU contribution

    € 4 944 347,50

Coordinated by:

UNIVERSITY OF BATH

United Kingdom