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Novel therapeutic strategies to treat pancreatic and lung cancer

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Publications

c-RAF Ablation Induces Regression of Advanced Kras/Trp 53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling

Author(s): Manuel Sanclemente, Sarah Francoz, Laura Esteban-Burgos, Emilie Bousquet-Mur, Magdolna Djurec, Pedro P. Lopez-Casas, Manuel Hidalgo, Carmen Guerra, Matthias Drosten, Monica Musteanu, Mariano Barbacid
Published in: Cancer Cell, Issue 33/2, 2018, Page(s) 217-228.e4, ISSN 1535-6108
DOI: 10.1016/j.ccell.2017.12.014

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer

Author(s): Lucía Simón-Carrasco, Gerardo Jiménez, Mariano Barbacid, Matthias Drosten
Published in: Cell Cycle, Issue 17/6, 2018, Page(s) 702-711, ISSN 1538-4101
DOI: 10.1080/15384101.2018.1450029

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors

Author(s): Magdolna Djurec, Osvaldo Graña, Albert Lee, Kevin Troulé, Elisa Espinet, Lavinia Cabras, Carolina Navas, María Teresa Blasco, Laura Martín-Díaz, Miranda Burdiel, Jing Li, Zhaoqi Liu, Mireia Vallespinós, Francisco Sanchez-Bueno, Martin R. Sprick, Andreas Trumpp, Bruno Sainz, Fátima Al-Shahrour, Raul Rabadan, Carmen Guerra, Mariano Barbacid
Published in: Proceedings of the National Academy of Sciences, Issue 115/6, 2018, Page(s) E1147-E1156, ISSN 0027-8424
DOI: 10.1073/pnas.1717802115

Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF

Author(s): María Teresa Blasco, Carolina Navas, Guillermo Martín-Serrano, Osvaldo Graña-Castro, Carmen G. Lechuga, Laura Martín-Díaz, Magdolna Djurec, Jing Li, Lucia Morales-Cacho, Laura Esteban-Burgos, Javier Perales-Patón, Emilie Bousquet-Mur, Eva Castellano, Harrys K.C. Jacob, Lavinia Cabras, Monica Musteanu, Matthias Drosten, Sagrario Ortega, Francisca Mulero, Bruno Sainz, Nelson Dusetti, Juan Iova
Published in: Cancer Cell, Issue 35/4, 2019, Page(s) 573-587.e6, ISSN 1535-6108
DOI: 10.1016/j.ccell.2019.03.002

Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets

Author(s): Matthias Drosten, Carmen Guerra, Mariano Barbacid
Published in: Cold Spring Harbor Perspectives in Medicine, Issue 8/5, 2018, Page(s) a031542, ISSN 2157-1422
DOI: 10.1101/cshperspect.a031542