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Electrostructural Tomography – Towards Multiparametric Imaging of Cardiac Electrical Disorders

Objectif

Cardiac electrical diseases are directly responsible for sudden cardiac death, heart failure and stroke. They result from a complex interplay between myocardial electrical activation and structural heterogeneity. Current diagnostic strategy based on separate electrocardiographic and imaging assessment is unable to grasp both these aspects. Improvements in personalised diagnostics are urgently needed as existing curative or preventive therapies (catheter ablation, multisite pacing, and implantable defibrillators) cannot be offered until patients are correctly recognised.
My aim is to achieve a major advance in the way cardiac electrical diseases are characterised and thus diagnosed and treated, through the development of a novel non-invasive modality (Electrostructural Tomography), combining magnetic resonance imaging (MRI) and non-invasive cardiac mapping (NIM) technologies.
The approach will consist of: (1) hybridising NIM and MRI technologies to enable the joint acquisition of magnetic resonance images of the heart and torso and of a large array of body surface potentials within a single environment; (2) personalising the inverse problem of electrocardiography based on MRI characteristics within the heart and torso, to enable accurate reconstruction of cardiac electrophysiological maps from body surface potentials within the 3D cardiac tissue; and (3) developing a novel disease characterisation framework based on registered non-invasive imaging and electrophysiological data, and propose novel diagnostic and prognostic markers.
This project will dramatically impact the tailored management of cardiac electrical disorders, with applications for diagnosis, risk stratification/patient selection and guidance of pacing and catheter ablation therapies. It will bridge two medical fields (cardiac electrophysiology and imaging), thereby creating a new research area and a novel semiology with the potential to modify the existing classification of cardiac electrical diseases.

Régime de financement

ERC-STG - Starting Grant

Institution d’accueil

UNIVERSITE DE BORDEAUX
Contribution nette de l'UE
€ 1 051 758,75
Adresse
Place Pey Berland 35
33000 Bordeaux
France

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Région
Nouvelle-Aquitaine Aquitaine Gironde
Type d’activité
Higher or Secondary Education Establishments
Autres sources de financement
€ 0,00

Bénéficiaires (3)

UNIVERSITE DE BORDEAUX
France
Contribution nette de l'UE
€ 1 051 758,75
Adresse
Place Pey Berland 35
33000 Bordeaux

Voir sur la carte

Région
Nouvelle-Aquitaine Aquitaine Gironde
Type d’activité
Higher or Secondary Education Establishments
Autres sources de financement
€ 0,00
Tiers

Entité juridique autre qu’un sous-traitant qui est affiliée ou juridiquement liée à un participant. L’entité réalise des travaux dans les conditions prévues par la convention de subvention, fournit des biens ou des services pour l’action, mais n’a pas signé la convention de subvention. Le tiers respecte les règles applicables au participant qui lui est lié dans le cadre de la convention de subvention en ce qui concerne l’éligibilité des coûts et le contrôle des dépenses.

CHU HOPITAUX DE BORDEAUX
France
Contribution nette de l'UE
€ 134 491,25
Adresse
Rue Dubernat 12
33404 Talence

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Région
Nouvelle-Aquitaine Aquitaine Gironde
Type d’activité
Higher or Secondary Education Establishments
Autres sources de financement
€ 0,00
INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE
France
Contribution nette de l'UE
€ 288 750,00
Adresse
Domaine De Voluceau Rocquencourt
78153 Le Chesnay Cedex

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Région
Ile-de-France Ile-de-France Yvelines
Type d’activité
Research Organisations
Autres sources de financement
€ 0,00