Tackling the Achilles Heel of Immunotherapy: Validating imaging biomarkers and targeting the immunological niche of tumour hypoxia

Publications

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

Author(s): Ashok Aspatwar, Nanda Kumar Parvathaneni, Harlan Barker, Emilie Anduran, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Seppo Parkkila, Jean-Yves Winum
Published in: Journal of Enzyme Inhibition and Medicinal Chemistry, Issue 35/1, 2020, Page(s) 109-117, ISSN 1475-6366
Publisher: Taylor & Francis
DOI: 10.1080/14756366.2019.1685510

Automated detection and segmentation of non-small cell lung cancer computed tomography images

Author(s): S.P. Primakov, A. Ibrahim, J.E. van Timmeren, G.Y. Wu, S.A. Keek, M. Beuque, R.W.Y. Granzier, E. Lavrova, M. Scrivener, S. Sanduleanu, E. Kayan, I. Halilaj, Anouk Lenaers, J.L. Wu, R. Monshouwer, X. Geets, H.A. Gietema, L.E.L. Hendriks, O. Morin, A. Jochems, H.C. Woodruff, P. Lambin
Published in: Nature Communications, Issue Vol. 13, No. 1., 2022, Page(s) 3423, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30841-3

Predicting Adverse Radiation Effects in Brain Tumors After Stereotactic Radiotherapy With Deep Learning and Handcrafted Radiomics

Author(s): Simon A Keek, Manon Beuque, Sergey Primakov, Henry C Woodruff, Avishek Chatterjee, Janita E van Timmeren, Martin Vallières, Lizza E L Hendriks, Johannes Kraft, Nicolaus Andratschke, Steve E Braunstein, Olivier Morin, Philippe Lambin
Published in: Frontiers in Oncology, Issue 12, [920393], 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.920393

Diagnosis of Invasive Lung Adenocarcinoma Based on Chest CT Radiomic Features of Part-Solid Pulmonary Nodules: A Multicenter Study

Author(s): Guangyao Wu, Henry C. Woodruff, Jing Shen, Turkey Refaee, Sebastian Sanduleanu, Abdalla Ibrahim, Ralph T. H. Leijenaar, Rui Wang, Jingtong Xiong, Jie Bian, Jianlin Wu, Philippe Lambin
Published in: Radiology, Issue 297(2), 2020, Page(s) 451-458, ISSN 0033-8419
Publisher: Radiological Society of North America
DOI: 10.1148/radiol.2020192431

A novel co-culture assay to assess anti-tumor CD8+ T cell cytotoxicity via luminescence and multicolor flow cytometry

Author(s): Verónica Olivo Pimentel, Ala Yaromina, Damiënne Marcus, Ludwig J. Dubois, Philippe Lambin
Published in: Journal of Immunological Methods, Issue 487, 2020, Page(s) 112899, ISSN 0022-1759
Publisher: Elsevier BV
DOI: 10.1016/j.jim.2020.112899

Nitroglycerin as a radiosensitizer in non-small cell lung cancer: Results of a prospective imaging-based phase II trial

Author(s): Bart J.T. Reymen, Marike W. van Gisbergen, Aniek J.G. Even, Catharina M.L. Zegers, Marco Das, Erik Vegt, Joachim E. Wildberger, Felix M. Mottaghy, Ala Yaromina, Ludwig J. Dubois, Wouter van Elmpt, Dirk De Ruysscher, and Philippe Lambin
Published in: Clinical and Translational Radiation Oncology, Issue 21, 2019, Page(s) 49-55, ISSN 2405-6308
Publisher: Elsevier
DOI: 10.1016/j.ctro.2019.12.002

Overcoming radioresistance with the hypoxia-activated prodrug CP-506: A pre-clinical study of local tumour control probability

Author(s): Ala Yaromina, Lydia Koi, Lesley Schuitmaker, Alexander van der Wiel, Ludwig Dubois, Mechthild Krause, Philippe Lambin
Published in: Radiotherapy and Oncology, Issue Online ahead of print., 2023, Page(s) 186, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/j.radonc.2023.109738

Human fibronectin extra domain B as a biomarker for targeted therapy in cancer

Author(s): Relinde I. Y. Lieverse, Damiënne Marcus, Alexander M. A. Wiel, Evert J. Van Limbergen, Jan Theys, Ala Yaromina, Philippe Lambin, Ludwig J. Dubois
Published in: Molecular Oncology, Issue 14/7, 2020, Page(s) 1555-1568, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.12705

Combining Deep Learning and Handcrafted Radiomics for Classification of Suspicious Lesions on Contrast-enhanced Mammograms

Author(s): Manon P. L. Beuque, Marc B. I. Lobbes, Yvonka van Wijk, Yousif Widaatalla, Sergey Primakov, Michael Majer, Corinne Balleyguier, Henry C. Woodruff, Philippe Lambin
Published in: Radiology, Issue 307(5), 2023, ISSN 0033-8419
Publisher: Radiological Society of North America
DOI: 10.1148/radiol.221843

Lymphocyte-Sparing Radiotherapy: The Rationale for Protecting Lymphocyte-rich Organs When Combining Radiotherapy With Immunotherapy

Author(s): Philippe Lambin, Relinde I.Y. Lieverse, Franziska Eckert, Damiënne Marcus, Cary Oberije, Alexander M.A. van der Wiel, Chandan Guha, Ludwig J. Dubois, Joseph O. Deasy
Published in: Seminars in Radiation Oncology, Issue 30/2, 2020, Page(s) 187-193, ISSN 1053-4296
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2019.12.003

Hypoxia-activated prodrug derivatives of anticancerdrugs: a patent review 2006 – 2021

Author(s): Emilie Anduran, Ludwig J Dubois, Philippe Lambin, Jean-Yves Winum
Published in: Expert Opinion on Therapeutic Patents, 2021, ISSN 1744-7674
Publisher: Taylor & Francis
DOI: 10.1080/13543776.2021.1954617

Efficient Secretion of Murine IL-2 From an Attenuated Strain of Clostridium sporogenes, a Novel Delivery Vehicle for Cancer Immunotherapy

Author(s): Aleksandra M. Kubiak, Tom S. Bailey, Ludwig J. Dubois, Jan Theys, Philippe Lambin
Published in: Frontiers in Microbiology, Issue 12, 2021, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2021.669488

Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells

Author(s): J. Kazokaite, Raymon Niemans, V. Dudutiene, Holger M. Becker, J. Leitans, A. Zubriene, L. Baranauskiene, Gabor Gondi, Reinhard Zeidler, J. Matuliene, K. Tars, Ala Yaromina, Philippe Lambin, Ludwig Dubois, D. Matulis
Published in: Oncotarget, Issue 9 (42), 2018, Page(s) 26800-26816, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.25508

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation

Author(s): Emilie Anduran, Ashok Aspatwar, Nanda-Kumar Parvathaneni, Dennis Suylen, Silvia Bua, Alessio Nocentini, Seppo Parkkila, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Jean-Yves Winum
Published in: Molecules, Issue 25/10, 2020, Page(s) 2347, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25102347

Toxicity of L19-Interleukin 2 Combined with Stereotactic Body Radiation Therapy: A Phase 1 Study

Author(s): Evert Jan Van Limbergen, Ann Hoeben, Relinde I.Y. Lieverse, Ruud Houben, Chantal Overhof, Alida Postma, Jaap Zindler, Frans Verhelst, Ludwig J. Dubois, Dirk De Ruysscher, Esther G.C. Troost, Philippe Lambin
Published in: International Journal of Radiation Oncology*Biology*Physics, Issue 109/5, 2021, Page(s) 1421-1430, ISSN 0360-3016
Publisher: Elsevier BV
DOI: 10.1016/j.ijrobp.2020.11.053

An artificial intelligence framework integrating longitudinal electronic health records with real-world data enables continuous pan-cancer prognostication

Author(s): Olivier Morin, Martin Vallières, Steve Braunstein, Jorge Barrios Ginart, Taman Upadhaya, Henry C. Woodruff, Alex Zwanenburg, Avishek Chatterjee, Javier E. Villanueva-Meyer, Gilmer Valdes, William Chen, Julian C. Hong, Sue S. Yom, Timothy D. Solberg, Steffen Löck, Jan Seuntjens, Catherine Park & Philippe Lambin
Published in: Nature Cancer, Issue 2, 2021, Page(s) 709–722, ISSN 2662-1347
Publisher: Springer
DOI: 10.1038/s43018-021-00236-2

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

Author(s): Alexander M A van der Wiel, Victoria Jackson-Patel, Raymon Niemans, Ala Yaromina, Emily Liu, Damiënne Marcus, Alexandra M Mowday, Natasja G Lieuwes, Rianne Biemans, Xiaojing Lin, Zhe Fu, Sisira Kumara, Arthur Jochems, Amir Ashoorzadeh, Robert F Anderson, Kevin O Hicks, Matthew R Bull, Maria R Abbattista, Christopher P Guise, Sofie Deschoemaeker, Sophie Thiolloy, Arne Heyerick, Morwena J Solivio,
Published in: Molecular Cancer Therapeutics, Issue 20 (12), 2021, Page(s) 2372-2383, ISSN 1535-7163
Publisher: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-21-0406

Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19–IL2 cures poorly immunogenic tumors when combined with radiotherapy

Author(s): Veronica Olivo Pimentel, Damiënne Marcus, Alexander MA van der Wiel, Natasja G Lieuwes, Rianne Biemans, Relinde IY Lieverse, Dario Neri, Jan Theys, Ala Yaromina, Ludwig J Dubois, Philippe Lambin
Published in: Journal for ImmunoTherapy of Cancer, Issue 9/3, 2021, Page(s) e001764, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2020-001764

Heterologous Gene Regulation in Clostridia: Rationally Designed Gene Regulation for Industrial and Medical Applications

Author(s): Yanchao Zhang, Tom S Bailey, Aleksandra M Kubiak, Philippe Lambin, Jan Theys
Published in: ACS Synthetic Biology, Issue 11 (11), 2022, Page(s) 3817–3828, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.2c00401

Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets

Author(s): Marike W van Gisbergen, Kelly Offermans, An M Voets, Natasja G Lieuwes, Rianne Biemans, Roland F Hoffmann, Ludwig J Dubois, Philippe Lambin
Published in: Frontiers in Oncology, Issue 10, [770], 2020, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00770

Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape

Author(s): Sara Hamis, Mohammad Kohandel, Ludwig J. Dubois, Ala Yaromina, Philippe Lambin, Gibin G. Powathil
Published in: PLOS Computational Biology, Issue 16/8, 2020, Page(s) e1008041, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1008041

The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses

Author(s): Nicolle H. Rekers, Veronica Olivo Pimentel, Ala Yaromina, Natasja G. Lieuwes, Rianne Biemans, Catharina M. L. Zegers, Wilfred T. V. Germeraad, Evert J. Van Limbergen, Dario Neri, Ludwig J. Dubois, Philippe Lambin
Published in: OncoImmunology, Issue 7/4, 2017, Page(s) e1414119, ISSN 2162-402X
Publisher: OncoImmunology
DOI: 10.1080/2162402X.2017.1414119

Combining radiotherapy with immunotherapy: the past, the present and the future

Author(s): Evert J Van Limbergen, Dirk K De Ruysscher, Veronica Olivo Pimentel, Damiënne Marcus, Maaike Berbee, Ann Hoeben, Nicolle Rekers, Jan Theys, Ala Yaromina, Ludwig J Dubois, Philippe Lambin
Published in: The British Journal of Radiology, Issue 90/1076, 2017, Page(s) 20170157, ISSN 0007-1285
Publisher: British Institute of Radiology
DOI: 10.1259/bjr.20170157

Quality assessment of positron emission tomography scans: recommendations for future multicentre trials

Author(s): Evelyn E. C. de Jong, Wouter van Elmpt, Otto S. Hoekstra, Harry J. M. Groen, Egbert F. Smit, Ronald Boellaard, Philippe Lambin, Anne-Marie C. Dingemans
Published in: Acta Oncologica, Issue 56/11, 2017, Page(s) 1459-1464, ISSN 0284-186X
Publisher: Taylor & Francis
DOI: 10.1080/0284186X.2017.1346824

Influence of gray level discretization on radiomic feature stability for different CT scanners, tube currents and slice thicknesses: a comprehensive phantom study

Author(s): Ruben T. H. M. Larue, Janna E. van Timmeren, Evelyn E. C. de Jong, Giacomo Feliciani, Ralph T. H. Leijenaar, Wendy M. J. Schreurs, Meindert N. Sosef, Frank H. P. J. Raat, Frans H. R. van der Zande, Marco Das, Wouter van Elmpt, Philippe Lambin
Published in: Acta Oncologica, Issue 56/11, 2017, Page(s) 1544-1553, ISSN 0284-186X
Publisher: Taylor & Francis
DOI: 10.1080/0284186X.2017.1351624

Feature selection methodology for longitudinal cone-beam CT radiomics

Author(s): Janna E. van Timmeren, Ralph T. H. Leijenaar, Wouter van Elmpt, Bart Reymen, Philippe Lambin
Published in: Acta Oncologica, Issue 56/11, 2017, Page(s) 1537-1543, ISSN 0284-186X
Publisher: Taylor & Francis
DOI: 10.1080/0284186X.2017.1350285

Radiomics: the bridge between medical imaging and personalized medicine

Author(s): Philippe Lambin, Ralph T.H. Leijenaar, Timo M. Deist, Jurgen Peerlings, Evelyn E.C. de Jong, Janita van Timmeren, Sebastian Sanduleanu, Ruben T.H.M. Larue, Aniek J.G. Even, Arthur Jochems, Yvonka van Wijk, Henry Woodruff, Johan van Soest, Tim Lustberg, Erik Roelofs, Wouter van Elmpt, Andre Dekker, Felix M. Mottaghy, Joachim E. Wildberger, Sean Walsh
Published in: Nature Reviews Clinical Oncology, Issue 14/12, 2017, Page(s) 749-762, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/nrclinonc.2017.141

Predicting tumor hypoxia in non-small cell lung cancer by combining CT, FDG PET and dynamic contrast-enhanced CT

Author(s): Aniek J. G. Even, Bart Reymen, Matthew D. La Fontaine, Marco Das, Arthur Jochems, Felix M. Mottaghy, José S. A. Belderbos, Dirk De Ruysscher, Philippe Lambin, Wouter van Elmpt
Published in: Acta Oncologica, Issue 56/11, 2017, Page(s) 1591-1596, ISSN 0284-186X
Publisher: Taylor & Francis
DOI: 10.1080/0284186X.2017.1349332

A prediction model for early death in non-small cell lung cancer patients following curative-intent chemoradiotherapy

Author(s): Arthur Jochems, Issam El-Naqa, Marc Kessler, Charles S. Mayo, Shruti Jolly, Martha Matuszak, Corinne Faivre-Finn, Gareth Price, Lois Holloway, Shalini Vinod, Matthew Field, Mohamed Samir Barakat, David Thwaites, Dirk de Ruysscher, Andre Dekker, Philippe Lambin
Published in: Acta Oncologica, Issue 57/2, 2017, Page(s) 226-230, ISSN 0284-186X
Publisher: Taylor & Francis
DOI: 10.1080/0284186X.2017.1385842

Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity

Author(s): Linda Spiegelberg, Stefan J. van Hoof, Rianne Biemans, Natasja G. Lieuwes, Damiënne Marcus, Raymon Niemans, Jan Theys, Ala Yaromina, Philippe Lambin, Frank Verhaegen, Ludwig J. Dubois
Published in: Radiotherapy and Oncology, 2019, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/j.radonc.2019.06.034

Hypoxia PET Imaging with [18F]-HX4—A Promising Next-Generation Tracer

Author(s): Sebastian Sanduleanu, Alexander M.A. van der Wiel, Relinde I.Y. Lieverse, Damiënne Marcus, Abdalla Ibrahim, Sergey Primakov, Guangyao Wu, Jan Theys, Ala Yaromina, Ludwig J. Dubois, Philippe Lambin
Published in: Cancers, Issue 12/5, 2020, Page(s) 1322, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12051322

Stereotactic ablative body radiotherapy (SABR) combined with immunotherapy (L19-IL2) versus standard of care in stage IV NSCLC patients, ImmunoSABR: a multicentre, randomised controlled open-label phase II trial

Author(s): Relinde I. Y. Lieverse, Evert J. Van Limbergen, Cary J. G. Oberije, Esther G. C. Troost, Sine R. Hadrup, Anne-Marie C. Dingemans, Lizza E. L. Hendriks, Franziska Eckert, Crispin Hiley, Christophe Dooms, Yolande Lievens, Monique C. de Jong, Johan Bussink, Xavier Geets, Vincenzo Valentini, Giuliano Elia, Dario Neri, Charlotte Billiet, Amir Abdollahi, David Pasquier, Pierre Boisselier, Ala Yaromina,
Published in: BMC Cancer, Issue 20/1, 2020, ISSN 1471-2407
Publisher: BioMed Central
DOI: 10.1186/s12885-020-07055-1

Non-invasive imaging prediction of tumor hypoxia: A novel developed and externally validated CT and FDG-PET-based radiomic signatures

Author(s): Sebastian Sanduleanu, Arthur Jochems, Taman Upadhaya, Aniek J.G. Even, Ralph T.H. Leijenaar, Frank J.W.M. Dankers, Remy Klaassen, Henry C. Woodruff, Mathieu Hatt, Hans J.A.M. Kaanders, Olga Hamming-Vrieze, Hanneke W.M. van Laarhoven, Rathan M. Subramiam, Shao Hui Huang, Brian O'Sullivan, Scott V. Bratman, Ludwig J. Dubois, Razvan L. Miclea, Dario Di Perri, Xavier Geets, Mireia Crispin-Ortuzar, Adi
Published in: Radiotherapy and Oncology, Issue 153, 2020, Page(s) 97-105, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/j.radonc.2020.10.016

Charged Particle and Conventional Radiotherapy: Current Implications as Partner for Immunotherapy

Author(s): Damiënne Marcus, Relinde I. Y. Lieverse, Carmen Klein, Amir Abdollahi, Philippe Lambin, Ludwig J. Dubois, Ala Yaromina
Published in: Cancers, Issue 13/6, 2021, Page(s) 1468, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061468

Development and validation of a computed tomography–based immune ecosystem diversity index as an imaging biomarker in non-small cell lung cancer

Author(s): Lan He, Zhen-Hui Li, Li-Xu Yan, Xin Chen, Sebastian Sanduleanu, Wen-Zhao Zhong, Phillippe Lambin, Zhao-Xiang Ye, Ying-Shi Sun, Yu-Lin Liu, Jin-Rong Qu, Lin Wu, Chang-Ling Tu, Madeleine Scrivener, Thierry Pieters, Emmanuel Coche, Qian Yang, Mei Yang, Chang-Hong Liang, Yan-Qi Huang & Zai-Yi Liu
Published in: European Radiology, 2022, Page(s) 8726–8736, ISSN 1432-1084
Publisher: Springer Link
DOI: 10.1007/s00330-022-08873-6

Intellectual Property Rights

Treatment and planning for lymphocytes sparing radiotherapy

Application/Publication number: NL 2025017
Date: 2020-02-28

Treatment and planning for lymphocytes sparing radiotherapy

Application/Publication number: NL 2025017
Date: 2020-02-28

Image data processing method, method of training a machine learning data processing model and image processing system

Application/Publication number: NL P124711NL00
Date: 2020-02-12

Non-invasive imaging prediction of tumor hypoxia

Application/Publication number: US 17/123,816
Date: 2020-12-16