Tackling the Achilles Heel of Immunotherapy: Validating imaging biomarkers and targeting the immunological niche of tumour hypoxia

Informazioni relative al progetto

HYPOXIMMUNO

ID dell’accordo di sovvenzione: 694812

DOI

10.3030/694812

Progetto chiuso

Data della firma CE 30 Novembre 2016

Data di avvio 1 Dicembre 2016

Data di completamento 31 Maggio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 399,00

Contributo UE

€ 2 499 399,00

Coordinato da

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (35)

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

Autori: Ashok Aspatwar, Nanda Kumar Parvathaneni, Harlan Barker, Emilie Anduran, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Seppo Parkkila, Jean-Yves Winum
Pubblicato in: Journal of Enzyme Inhibition and Medicinal Chemistry, Numero 35/1, 2020, Pagina/e 109-117, ISSN 1475-6366
Editore: Taylor & Francis
DOI: 10.1080/14756366.2019.1685510

Automated detection and segmentation of non-small cell lung cancer computed tomography images

Autori: S.P. Primakov, A. Ibrahim, J.E. van Timmeren, G.Y. Wu, S.A. Keek, M. Beuque, R.W.Y. Granzier, E. Lavrova, M. Scrivener, S. Sanduleanu, E. Kayan, I. Halilaj, Anouk Lenaers, J.L. Wu, R. Monshouwer, X. Geets, H.A. Gietema, L.E.L. Hendriks, O. Morin, A. Jochems, H.C. Woodruff, P. Lambin
Pubblicato in: Nature Communications, Numero Vol. 13, No. 1., 2022, Pagina/e 3423, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-30841-3

Predicting Adverse Radiation Effects in Brain Tumors After Stereotactic Radiotherapy With Deep Learning and Handcrafted Radiomics

Autori: Simon A Keek, Manon Beuque, Sergey Primakov, Henry C Woodruff, Avishek Chatterjee, Janita E van Timmeren, Martin Vallières, Lizza E L Hendriks, Johannes Kraft, Nicolaus Andratschke, Steve E Braunstein, Olivier Morin, Philippe Lambin
Pubblicato in: Frontiers in Oncology, Numero 12, [920393], 2022, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.920393

Diagnosis of Invasive Lung Adenocarcinoma Based on Chest CT Radiomic Features of Part-Solid Pulmonary Nodules: A Multicenter Study

Autori: Guangyao Wu, Henry C. Woodruff, Jing Shen, Turkey Refaee, Sebastian Sanduleanu, Abdalla Ibrahim, Ralph T. H. Leijenaar, Rui Wang, Jingtong Xiong, Jie Bian, Jianlin Wu, Philippe Lambin
Pubblicato in: Radiology, Numero 297(2), 2020, Pagina/e 451-458, ISSN 0033-8419
Editore: Radiological Society of North America
DOI: 10.1148/radiol.2020192431

A novel co-culture assay to assess anti-tumor CD8+ T cell cytotoxicity via luminescence and multicolor flow cytometry

Autori: Verónica Olivo Pimentel, Ala Yaromina, Damiënne Marcus, Ludwig J. Dubois, Philippe Lambin
Pubblicato in: Journal of Immunological Methods, Numero 487, 2020, Pagina/e 112899, ISSN 0022-1759
Editore: Elsevier BV
DOI: 10.1016/j.jim.2020.112899

Nitroglycerin as a radiosensitizer in non-small cell lung cancer: Results of a prospective imaging-based phase II trial

Autori: Bart J.T. Reymen, Marike W. van Gisbergen, Aniek J.G. Even, Catharina M.L. Zegers, Marco Das, Erik Vegt, Joachim E. Wildberger, Felix M. Mottaghy, Ala Yaromina, Ludwig J. Dubois, Wouter van Elmpt, Dirk De Ruysscher, and Philippe Lambin
Pubblicato in: Clinical and Translational Radiation Oncology, Numero 21, 2019, Pagina/e 49-55, ISSN 2405-6308
Editore: Elsevier
DOI: 10.1016/j.ctro.2019.12.002

Overcoming radioresistance with the hypoxia-activated prodrug CP-506: A pre-clinical study of local tumour control probability

Autori: Ala Yaromina, Lydia Koi, Lesley Schuitmaker, Alexander van der Wiel, Ludwig Dubois, Mechthild Krause, Philippe Lambin
Pubblicato in: Radiotherapy and Oncology, Numero Online ahead of print., 2023, Pagina/e 186, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2023.109738

Human fibronectin extra domain B as a biomarker for targeted therapy in cancer

Autori: Relinde I. Y. Lieverse, Damiënne Marcus, Alexander M. A. Wiel, Evert J. Van Limbergen, Jan Theys, Ala Yaromina, Philippe Lambin, Ludwig J. Dubois
Pubblicato in: Molecular Oncology, Numero 14/7, 2020, Pagina/e 1555-1568, ISSN 1574-7891
Editore: Elsevier BV
DOI: 10.1002/1878-0261.12705

Combining Deep Learning and Handcrafted Radiomics for Classification of Suspicious Lesions on Contrast-enhanced Mammograms

Autori: Manon P. L. Beuque, Marc B. I. Lobbes, Yvonka van Wijk, Yousif Widaatalla, Sergey Primakov, Michael Majer, Corinne Balleyguier, Henry C. Woodruff, Philippe Lambin
Pubblicato in: Radiology, Numero 307(5), 2023, ISSN 0033-8419
Editore: Radiological Society of North America
DOI: 10.1148/radiol.221843

Lymphocyte-Sparing Radiotherapy: The Rationale for Protecting Lymphocyte-rich Organs When Combining Radiotherapy With Immunotherapy

Autori: Philippe Lambin, Relinde I.Y. Lieverse, Franziska Eckert, Damiënne Marcus, Cary Oberije, Alexander M.A. van der Wiel, Chandan Guha, Ludwig J. Dubois, Joseph O. Deasy
Pubblicato in: Seminars in Radiation Oncology, Numero 30/2, 2020, Pagina/e 187-193, ISSN 1053-4296
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.semradonc.2019.12.003

Hypoxia-activated prodrug derivatives of anticancerdrugs: a patent review 2006 – 2021

Autori: Emilie Anduran, Ludwig J Dubois, Philippe Lambin, Jean-Yves Winum
Pubblicato in: Expert Opinion on Therapeutic Patents, 2021, ISSN 1744-7674
Editore: Taylor & Francis
DOI: 10.1080/13543776.2021.1954617

Efficient Secretion of Murine IL-2 From an Attenuated Strain of Clostridium sporogenes, a Novel Delivery Vehicle for Cancer Immunotherapy

Autori: Aleksandra M. Kubiak, Tom S. Bailey, Ludwig J. Dubois, Jan Theys, Philippe Lambin
Pubblicato in: Frontiers in Microbiology, Numero 12, 2021, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2021.669488

Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells

Autori: J. Kazokaite, Raymon Niemans, V. Dudutiene, Holger M. Becker, J. Leitans, A. Zubriene, L. Baranauskiene, Gabor Gondi, Reinhard Zeidler, J. Matuliene, K. Tars, Ala Yaromina, Philippe Lambin, Ludwig Dubois, D. Matulis
Pubblicato in: Oncotarget, Numero 9 (42), 2018, Pagina/e 26800-26816, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.25508

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation

Autori: Emilie Anduran, Ashok Aspatwar, Nanda-Kumar Parvathaneni, Dennis Suylen, Silvia Bua, Alessio Nocentini, Seppo Parkkila, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Jean-Yves Winum
Pubblicato in: Molecules, Numero 25/10, 2020, Pagina/e 2347, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25102347

Toxicity of L19-Interleukin 2 Combined with Stereotactic Body Radiation Therapy: A Phase 1 Study

Autori: Evert Jan Van Limbergen, Ann Hoeben, Relinde I.Y. Lieverse, Ruud Houben, Chantal Overhof, Alida Postma, Jaap Zindler, Frans Verhelst, Ludwig J. Dubois, Dirk De Ruysscher, Esther G.C. Troost, Philippe Lambin
Pubblicato in: International Journal of Radiation Oncology*Biology*Physics, Numero 109/5, 2021, Pagina/e 1421-1430, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1016/j.ijrobp.2020.11.053

An artificial intelligence framework integrating longitudinal electronic health records with real-world data enables continuous pan-cancer prognostication

Autori: Olivier Morin, Martin Vallières, Steve Braunstein, Jorge Barrios Ginart, Taman Upadhaya, Henry C. Woodruff, Alex Zwanenburg, Avishek Chatterjee, Javier E. Villanueva-Meyer, Gilmer Valdes, William Chen, Julian C. Hong, Sue S. Yom, Timothy D. Solberg, Steffen Löck, Jan Seuntjens, Catherine Park & Philippe Lambin
Pubblicato in: Nature Cancer, Numero 2, 2021, Pagina/e 709–722, ISSN 2662-1347
Editore: Springer
DOI: 10.1038/s43018-021-00236-2

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

Autori: Alexander M A van der Wiel, Victoria Jackson-Patel, Raymon Niemans, Ala Yaromina, Emily Liu, Damiënne Marcus, Alexandra M Mowday, Natasja G Lieuwes, Rianne Biemans, Xiaojing Lin, Zhe Fu, Sisira Kumara, Arthur Jochems, Amir Ashoorzadeh, Robert F Anderson, Kevin O Hicks, Matthew R Bull, Maria R Abbattista, Christopher P Guise, Sofie Deschoemaeker, Sophie Thiolloy, Arne Heyerick, Morwena J Solivio,
Pubblicato in: Molecular Cancer Therapeutics, Numero 20 (12), 2021, Pagina/e 2372-2383, ISSN 1535-7163
Editore: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-21-0406

Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19–IL2 cures poorly immunogenic tumors when combined with radiotherapy

Autori: Veronica Olivo Pimentel, Damiënne Marcus, Alexander MA van der Wiel, Natasja G Lieuwes, Rianne Biemans, Relinde IY Lieverse, Dario Neri, Jan Theys, Ala Yaromina, Ludwig J Dubois, Philippe Lambin
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 9/3, 2021, Pagina/e e001764, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2020-001764

Heterologous Gene Regulation in Clostridia: Rationally Designed Gene Regulation for Industrial and Medical Applications

Autori: Yanchao Zhang, Tom S Bailey, Aleksandra M Kubiak, Philippe Lambin, Jan Theys
Pubblicato in: ACS Synthetic Biology, Numero 11 (11), 2022, Pagina/e 3817–3828, ISSN 2161-5063
Editore: American Chemical Society
DOI: 10.1021/acssynbio.2c00401

Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets

Autori: Marike W van Gisbergen, Kelly Offermans, An M Voets, Natasja G Lieuwes, Rianne Biemans, Roland F Hoffmann, Ludwig J Dubois, Philippe Lambin
Pubblicato in: Frontiers in Oncology, Numero 10, [770], 2020, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.00770

Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape

Autori: Sara Hamis, Mohammad Kohandel, Ludwig J. Dubois, Ala Yaromina, Philippe Lambin, Gibin G. Powathil
Pubblicato in: PLOS Computational Biology, Numero 16/8, 2020, Pagina/e e1008041, ISSN 1553-7358
Editore: PLOS
DOI: 10.1371/journal.pcbi.1008041

The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses

Autori: Nicolle H. Rekers, Veronica Olivo Pimentel, Ala Yaromina, Natasja G. Lieuwes, Rianne Biemans, Catharina M. L. Zegers, Wilfred T. V. Germeraad, Evert J. Van Limbergen, Dario Neri, Ludwig J. Dubois, Philippe Lambin
Pubblicato in: OncoImmunology, Numero 7/4, 2017, Pagina/e e1414119, ISSN 2162-402X
Editore: OncoImmunology
DOI: 10.1080/2162402X.2017.1414119

Combining radiotherapy with immunotherapy: the past, the present and the future

Autori: Evert J Van Limbergen, Dirk K De Ruysscher, Veronica Olivo Pimentel, Damiënne Marcus, Maaike Berbee, Ann Hoeben, Nicolle Rekers, Jan Theys, Ala Yaromina, Ludwig J Dubois, Philippe Lambin
Pubblicato in: The British Journal of Radiology, Numero 90/1076, 2017, Pagina/e 20170157, ISSN 0007-1285
Editore: British Institute of Radiology
DOI: 10.1259/bjr.20170157

Quality assessment of positron emission tomography scans: recommendations for future multicentre trials

Autori: Evelyn E. C. de Jong, Wouter van Elmpt, Otto S. Hoekstra, Harry J. M. Groen, Egbert F. Smit, Ronald Boellaard, Philippe Lambin, Anne-Marie C. Dingemans
Pubblicato in: Acta Oncologica, Numero 56/11, 2017, Pagina/e 1459-1464, ISSN 0284-186X
Editore: Taylor & Francis
DOI: 10.1080/0284186X.2017.1346824

Influence of gray level discretization on radiomic feature stability for different CT scanners, tube currents and slice thicknesses: a comprehensive phantom study

Autori: Ruben T. H. M. Larue, Janna E. van Timmeren, Evelyn E. C. de Jong, Giacomo Feliciani, Ralph T. H. Leijenaar, Wendy M. J. Schreurs, Meindert N. Sosef, Frank H. P. J. Raat, Frans H. R. van der Zande, Marco Das, Wouter van Elmpt, Philippe Lambin
Pubblicato in: Acta Oncologica, Numero 56/11, 2017, Pagina/e 1544-1553, ISSN 0284-186X
Editore: Taylor & Francis
DOI: 10.1080/0284186X.2017.1351624

Feature selection methodology for longitudinal cone-beam CT radiomics

Autori: Janna E. van Timmeren, Ralph T. H. Leijenaar, Wouter van Elmpt, Bart Reymen, Philippe Lambin
Pubblicato in: Acta Oncologica, Numero 56/11, 2017, Pagina/e 1537-1543, ISSN 0284-186X
Editore: Taylor & Francis
DOI: 10.1080/0284186X.2017.1350285

Radiomics: the bridge between medical imaging and personalized medicine

Autori: Philippe Lambin, Ralph T.H. Leijenaar, Timo M. Deist, Jurgen Peerlings, Evelyn E.C. de Jong, Janita van Timmeren, Sebastian Sanduleanu, Ruben T.H.M. Larue, Aniek J.G. Even, Arthur Jochems, Yvonka van Wijk, Henry Woodruff, Johan van Soest, Tim Lustberg, Erik Roelofs, Wouter van Elmpt, Andre Dekker, Felix M. Mottaghy, Joachim E. Wildberger, Sean Walsh
Pubblicato in: Nature Reviews Clinical Oncology, Numero 14/12, 2017, Pagina/e 749-762, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/nrclinonc.2017.141

Predicting tumor hypoxia in non-small cell lung cancer by combining CT, FDG PET and dynamic contrast-enhanced CT

Autori: Aniek J. G. Even, Bart Reymen, Matthew D. La Fontaine, Marco Das, Arthur Jochems, Felix M. Mottaghy, José S. A. Belderbos, Dirk De Ruysscher, Philippe Lambin, Wouter van Elmpt
Pubblicato in: Acta Oncologica, Numero 56/11, 2017, Pagina/e 1591-1596, ISSN 0284-186X
Editore: Taylor & Francis
DOI: 10.1080/0284186X.2017.1349332

A prediction model for early death in non-small cell lung cancer patients following curative-intent chemoradiotherapy

Autori: Arthur Jochems, Issam El-Naqa, Marc Kessler, Charles S. Mayo, Shruti Jolly, Martha Matuszak, Corinne Faivre-Finn, Gareth Price, Lois Holloway, Shalini Vinod, Matthew Field, Mohamed Samir Barakat, David Thwaites, Dirk de Ruysscher, Andre Dekker, Philippe Lambin
Pubblicato in: Acta Oncologica, Numero 57/2, 2017, Pagina/e 226-230, ISSN 0284-186X
Editore: Taylor & Francis
DOI: 10.1080/0284186X.2017.1385842

Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity

Autori: Linda Spiegelberg, Stefan J. van Hoof, Rianne Biemans, Natasja G. Lieuwes, Damiënne Marcus, Raymon Niemans, Jan Theys, Ala Yaromina, Philippe Lambin, Frank Verhaegen, Ludwig J. Dubois
Pubblicato in: Radiotherapy and Oncology, 2019, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2019.06.034

Hypoxia PET Imaging with [18F]-HX4—A Promising Next-Generation Tracer

Autori: Sebastian Sanduleanu, Alexander M.A. van der Wiel, Relinde I.Y. Lieverse, Damiënne Marcus, Abdalla Ibrahim, Sergey Primakov, Guangyao Wu, Jan Theys, Ala Yaromina, Ludwig J. Dubois, Philippe Lambin
Pubblicato in: Cancers, Numero 12/5, 2020, Pagina/e 1322, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12051322

Stereotactic ablative body radiotherapy (SABR) combined with immunotherapy (L19-IL2) versus standard of care in stage IV NSCLC patients, ImmunoSABR: a multicentre, randomised controlled open-label phase II trial

Autori: Relinde I. Y. Lieverse, Evert J. Van Limbergen, Cary J. G. Oberije, Esther G. C. Troost, Sine R. Hadrup, Anne-Marie C. Dingemans, Lizza E. L. Hendriks, Franziska Eckert, Crispin Hiley, Christophe Dooms, Yolande Lievens, Monique C. de Jong, Johan Bussink, Xavier Geets, Vincenzo Valentini, Giuliano Elia, Dario Neri, Charlotte Billiet, Amir Abdollahi, David Pasquier, Pierre Boisselier, Ala Yaromina,
Pubblicato in: BMC Cancer, Numero 20/1, 2020, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-020-07055-1

Non-invasive imaging prediction of tumor hypoxia: A novel developed and externally validated CT and FDG-PET-based radiomic signatures

Autori: Sebastian Sanduleanu, Arthur Jochems, Taman Upadhaya, Aniek J.G. Even, Ralph T.H. Leijenaar, Frank J.W.M. Dankers, Remy Klaassen, Henry C. Woodruff, Mathieu Hatt, Hans J.A.M. Kaanders, Olga Hamming-Vrieze, Hanneke W.M. van Laarhoven, Rathan M. Subramiam, Shao Hui Huang, Brian O'Sullivan, Scott V. Bratman, Ludwig J. Dubois, Razvan L. Miclea, Dario Di Perri, Xavier Geets, Mireia Crispin-Ortuzar, Adi
Pubblicato in: Radiotherapy and Oncology, Numero 153, 2020, Pagina/e 97-105, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2020.10.016

Charged Particle and Conventional Radiotherapy: Current Implications as Partner for Immunotherapy

Autori: Damiënne Marcus, Relinde I. Y. Lieverse, Carmen Klein, Amir Abdollahi, Philippe Lambin, Ludwig J. Dubois, Ala Yaromina
Pubblicato in: Cancers, Numero 13/6, 2021, Pagina/e 1468, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061468

Development and validation of a computed tomography–based immune ecosystem diversity index as an imaging biomarker in non-small cell lung cancer

Autori: Lan He, Zhen-Hui Li, Li-Xu Yan, Xin Chen, Sebastian Sanduleanu, Wen-Zhao Zhong, Phillippe Lambin, Zhao-Xiang Ye, Ying-Shi Sun, Yu-Lin Liu, Jin-Rong Qu, Lin Wu, Chang-Ling Tu, Madeleine Scrivener, Thierry Pieters, Emmanuel Coche, Qian Yang, Mei Yang, Chang-Hong Liang, Yan-Qi Huang & Zai-Yi Liu
Pubblicato in: European Radiology, 2022, Pagina/e 8726–8736, ISSN 1432-1084
Editore: Springer Link
DOI: 10.1007/s00330-022-08873-6

Diritti di proprietà intellettuale

Other (3)

Treatment and planning for lymphocytes sparing radiotherapy

Numero candidatura/pubblicazione: NL 2025017
Data: 2020-02-28
Candidato/i: UNIVERSITEIT MAASTRICHT

Image data processing method, method of training a machine learning data processing model and image processing system

Numero candidatura/pubblicazione: NL P124711NL00
Data: 2020-02-12
Candidato/i: UNIVERSITEIT MAASTRICHT

Non-invasive imaging prediction of tumor hypoxia

Numero candidatura/pubblicazione: US 17/123,816
Data: 2020-12-16
Candidato/i: UNIVERSITEIT MAASTRICHT