Development of a Next-Generation, Dual-Target Rabies/Flavivirus Infectious DNA (iDNA) Vaccine

Project Information

RABYD-VAX

Grant agreement ID: 733176

DOI 10.3030/733176

Project closed

EC signature date 1 December 2016

Start date 1 January 2017

End date 31 December 2021

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 4 113 385,00

EU contribution € 4 113 385,00

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (2)

Update of dissemination and communication measures

This document summarises the updated communication and dissemination measuresNow also including i the poster or Ppt presentations given at international conferences iiscientific publications iii nonconfidential data package ivinternational symposium minutes

Dissemination and Communication Measures

This report summarises all dissemination and communication measures established during the first year: (i) project website, (ii) press release at time of kick-off meeting, (iii) social media, (iv) PowerPoint template with logo, (v) provisional MOOC.

Publications

Peer reviewed articles (16)

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

Author(s): Lorena Sanchez-Felipe, Thomas Vercruysse, Sapna Sharma, Ji Ma, Viktor Lemmens, Dominique Van Looveren, Mahadesh Prasad Arkalagud Javarappa, Robbert Boudewijns, Bert Malengier-Devlies, Laurens Liesenborghs, Suzanne J. F. Kaptein, Carolien De Keyzer, Lindsey Bervoets, Sarah Debaveye, Madina Rasulova, Laura Seldeslachts, Li-Hsin Li, Sander Jansen, Michael Bright Yakass, Babs E. Verstrepen, Kinga P. B
Published in: Nature, Issue 590/7845, 2021, Page(s) 320-325, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-3035-9

A Chimeric Japanese Encephalitis Vaccine Protects against Lethal Yellow Fever Virus Infection without Inducing Neutralizing Antibodies

Author(s): Niraj Mishra, Robbert Boudewijns, Michael Alexander Schmid, Rafael Elias Marques, Sapna Sharma, Johan Neyts, Kai Dallmeier
Published in: mBio, Issue 11/2, 2020, ISSN 2161-2129
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.02494-19

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Author(s): Robbert Boudewijns, Hendrik Jan Thibaut, Suzanne J. F. Kaptein, Rong Li, Valentijn Vergote, Laura Seldeslachts, Johan Van Weyenbergh, Carolien De Keyzer, Lindsey Bervoets, Sapna Sharma, Laurens Liesenborghs, Ji Ma, Sander Jansen, Dominique Van Looveren, Thomas Vercruysse, Xinyu Wang, Dirk Jochmans, Erik Martens, Kenny Roose, Dorien De Vlieger, Bert Schepens, Tina Van Buyten, Sofie Jacobs, Yanan Li
Published in: Nature Communications, Issue 11/1, 2020, Page(s) 5838, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19684-y

Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice

Author(s): Ji Ma; Robbert Boudewijns; Lorena Sanchez-Felipe; Niraj Mishra; Niraj Mishra; Thomas Vercruysse; Dieudonné Buh Kum; Hendrik Jan Thibaut; Johan Neyts; Johan Neyts; Kai Dallmeier; Kai Dallmeier
Published in: Emerging Microbes & Infections, Issue 1, 2021, Page(s) 2279-2290, ISSN 2222-1751
Publisher: Nature Publishing Group
DOI: 10.1080/22221751.2021.2008772

Towards rabies elimination in the Asia-Pacific region: From theory to practice

Author(s): Charles E. Rupprecht, Bernadette Abela-Ridder, Ronello Abila, Anna Charinna Amparo, Ashley Banyard, Jesse Blanton, Karoon Chanachai, Kai Dallmeier, Katinka de Balogh, Victor Del Rio Vilas, Hildegund Ertl, Conrad Freuling, Richard Hill, Guy Houillon, Miia Jakava-Viljanen, Suwicha Kasemsuwan, Jacques Léchenet, Louis Nel, Pranee Panichabhongse, Sira Abdul Rahman, Terapong Tantawichien, Joris Vandepu
Published in: Biologicals, Issue 64, 2020, Page(s) 83-95, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2020.01.008

Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine

Author(s): Sapna Sharma, Michael A. Schmid, Lorena Sanchez Felipe, Jana Grenelle, Suzanne J.F. Kaptein, Lotte Coelmont, Johan Neyts, Kai Dallmeier
Published in: Human Vaccines & Immunotherapeutics, Issue 16/9, 2020, Page(s) 2196-2203, ISSN 2164-5515
Publisher: Landes Bioscience
DOI: 10.1080/21645515.2020.1765621

Current Rabies Vaccines Do Not Confer Protective Immunity against Divergent Lyssaviruses Circulating in Europe

Author(s): Juan E. Echevarría, Ashley C. Banyard, Lorraine M. McElhinney, Anthony R. Fooks
Published in: Viruses, Issue 11/10, 2019, Page(s) 892, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11100892

MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain

Author(s): E. Kip, J. Staal, L. Verstrepen, H. G. Tima, S. Terryn, M. Romano, K. Lemeire, V. Suin, A. Hamouda, M. Kalai, R. Beyaert, S. Van Gucht
Published in: Journal of Virology, Issue 92/8, 2018, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/JVI.02029-17

Utilisation of Chimeric Lyssaviruses to Assess Vaccine Protection against Highly Divergent Lyssaviruses

Author(s): Jennifer Evans, Guanghui Wu, David Selden, Hubert Buczkowski, Leigh Thorne, Anthony Fooks, Ashley Banyard
Published in: Viruses, Issue 10/3, 2018, Page(s) 130, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10030130

A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice

Author(s): Dieudonné B. Kum, Niraj Mishra, Robbert Boudewijns, Ivan Gladwyn-Ng, Christian Alfano, Ji Ma, Michael A. Schmid, Rafael E. Marques, Dominique Schols, Suzanne Kaptein, Laurent Nguyen, Johan Neyts, Kai Dallmeier
Published in: npj Vaccines, Issue 3/1, 2018, ISSN 2059-0105
Publisher: Springer Nature
DOI: 10.1038/s41541-018-0092-2

Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS

Author(s): Samuel P. Smith, Guanghui Wu, Anthony R. Fooks, Julian Ma, Ashley C. Banyard
Published in: Journal of General Virology, Issue 100/8, 2019, Page(s) 1171-1186, ISSN 0022-1317
Publisher: Society for General Microbiology
DOI: 10.1099/jgv.0.001269

Isolation, antigenicity and immunogenicity of Lleida bat lyssavirus

Author(s): Ashley C. Banyard, David Selden, Guanghui Wu, Leigh Thorne, Daisy Jennings, Denise Marston, Stefan Finke, Conrad M. Freuling, Thomas Müller, Juan E. Echevarría, Anthony R. Fooks
Published in: Journal of General Virology, Issue 99/12, 2018, Page(s) 1590-1599, ISSN 0022-1317
Publisher: Society for General Microbiology
DOI: 10.1099/jgv.0.001068

Bats and Viruses: Emergence of Novel Lyssaviruses and Association of Bats with Viral Zoonoses in the EU

Author(s): Rebecca Shipley, Edward Wright, David Selden, Guanghui Wu, James Aegerter, Anthony R Fooks, Ashley C Banyard
Published in: Tropical Medicine and Infectious Disease, Issue 4/1, 2019, Page(s) 31, ISSN 2414-6366
Publisher: Basel
DOI: 10.3390/tropicalmed4010031

Limited evolution of the yellow fever virus 17d in a mouse infection model

Author(s): Dieudonné Buh Kum, Niraj Mishra, Bram Vrancken, Hendrik Jan Thibaut, Annelies Wilder-Smith, Philippe Lemey, Johan Neyts, Kai Dallmeier
Published in: Emerging Microbes & Infections, Issue 8/1, 2019, Page(s) 1734-1746, ISSN 2222-1751
Publisher: Nature Publishing Group
DOI: 10.1080/22221751.2019.1694394

A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice

Author(s): Dieudonné Buh Kum, Robbert Boudewijns, Ji Ma, Niraj Mishra, Dominique Schols, Johan Neyts, Kai Dallmeier
Published in: Emerging Microbes & Infections, Issue 9/1, 2020, Page(s) 520-533, ISSN 2222-1751
Publisher: Nature Publishing Group
DOI: 10.1080/22221751.2020.1730709

Assessing Rabies Vaccine Protection against a Novel Lyssavirus, Kotalahti Bat Lyssavirus

Author(s): Rebecca Shipley, Edward Wright, Fabian Z. X. Lean, David Selden, Daniel L. Horton, Anthony R. Fooks, Ashley C. Banyard
Published in: Viruses, Issue 13/5, 2021, Page(s) 947, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13050947

Intellectual Property Rights

Patent (4)

CHIMERIC FLAVIVIRUS VACCINES

Application/Publication number: 20 18077156
Date: 2018-10-05

CHIMERIC YELLOW FEVER ZIKA VIRUS STRAIN

Application/Publication number: 20 18077167
Date: 2018-10-05
Applicant(s): KATHOLIEKE UNIVERSITEIT LEUVEN

CHIMERIC FLAVIVIRUS VACCINES

Application/Publication number: 20 18077156
Date: 2018-10-05
Applicant(s): KATHOLIEKE UNIVERSITEIT LEUVEN

CHIMERIC YELLOW FEVER ZIKA VIRUS STRAIN

Application/Publication number: 20 18077167
Date: 2018-10-05