Development of a Next-Generation, Dual-Target Rabies/Flavivirus Infectious DNA (iDNA) Vaccine

Informazioni relative al progetto

RABYD-VAX

ID dell’accordo di sovvenzione: 733176

DOI

10.3030/733176

Progetto chiuso

Data della firma CE 1 Dicembre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 31 Dicembre 2021

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 4 113 385,00

Contributo UE

€ 4 113 385,00

Coordinato da

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Update of dissemination and communication measures

This document summarises the updated communication and dissemination measuresNow also including i the poster or Ppt presentations given at international conferences iiscientific publications iii nonconfidential data package ivinternational symposium minutes

Dissemination and Communication Measures

This report summarises all dissemination and communication measures established during the first year: (i) project website, (ii) press release at time of kick-off meeting, (iii) social media, (iv) PowerPoint template with logo, (v) provisional MOOC.

Pubblicazioni

Peer reviewed articles (16)

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

Autori: Lorena Sanchez-Felipe, Thomas Vercruysse, Sapna Sharma, Ji Ma, Viktor Lemmens, Dominique Van Looveren, Mahadesh Prasad Arkalagud Javarappa, Robbert Boudewijns, Bert Malengier-Devlies, Laurens Liesenborghs, Suzanne J. F. Kaptein, Carolien De Keyzer, Lindsey Bervoets, Sarah Debaveye, Madina Rasulova, Laura Seldeslachts, Li-Hsin Li, Sander Jansen, Michael Bright Yakass, Babs E. Verstrepen, Kinga P. B
Pubblicato in: Nature, Numero 590/7845, 2021, Pagina/e 320-325, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-3035-9

A Chimeric Japanese Encephalitis Vaccine Protects against Lethal Yellow Fever Virus Infection without Inducing Neutralizing Antibodies

Autori: Niraj Mishra, Robbert Boudewijns, Michael Alexander Schmid, Rafael Elias Marques, Sapna Sharma, Johan Neyts, Kai Dallmeier
Pubblicato in: mBio, Numero 11/2, 2020, ISSN 2161-2129
Editore: American Society for Microbiology
DOI: 10.1128/mbio.02494-19

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Autori: Robbert Boudewijns, Hendrik Jan Thibaut, Suzanne J. F. Kaptein, Rong Li, Valentijn Vergote, Laura Seldeslachts, Johan Van Weyenbergh, Carolien De Keyzer, Lindsey Bervoets, Sapna Sharma, Laurens Liesenborghs, Ji Ma, Sander Jansen, Dominique Van Looveren, Thomas Vercruysse, Xinyu Wang, Dirk Jochmans, Erik Martens, Kenny Roose, Dorien De Vlieger, Bert Schepens, Tina Van Buyten, Sofie Jacobs, Yanan Li
Pubblicato in: Nature Communications, Numero 11/1, 2020, Pagina/e 5838, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19684-y

Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice

Autori: Ji Ma; Robbert Boudewijns; Lorena Sanchez-Felipe; Niraj Mishra; Niraj Mishra; Thomas Vercruysse; Dieudonné Buh Kum; Hendrik Jan Thibaut; Johan Neyts; Johan Neyts; Kai Dallmeier; Kai Dallmeier
Pubblicato in: Emerging Microbes & Infections, Numero 1, 2021, Pagina/e 2279-2290, ISSN 2222-1751
Editore: Nature Publishing Group
DOI: 10.1080/22221751.2021.2008772

Towards rabies elimination in the Asia-Pacific region: From theory to practice

Autori: Charles E. Rupprecht, Bernadette Abela-Ridder, Ronello Abila, Anna Charinna Amparo, Ashley Banyard, Jesse Blanton, Karoon Chanachai, Kai Dallmeier, Katinka de Balogh, Victor Del Rio Vilas, Hildegund Ertl, Conrad Freuling, Richard Hill, Guy Houillon, Miia Jakava-Viljanen, Suwicha Kasemsuwan, Jacques Léchenet, Louis Nel, Pranee Panichabhongse, Sira Abdul Rahman, Terapong Tantawichien, Joris Vandepu
Pubblicato in: Biologicals, Numero 64, 2020, Pagina/e 83-95, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2020.01.008

Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine

Autori: Sapna Sharma, Michael A. Schmid, Lorena Sanchez Felipe, Jana Grenelle, Suzanne J.F. Kaptein, Lotte Coelmont, Johan Neyts, Kai Dallmeier
Pubblicato in: Human Vaccines & Immunotherapeutics, Numero 16/9, 2020, Pagina/e 2196-2203, ISSN 2164-5515
Editore: Landes Bioscience
DOI: 10.1080/21645515.2020.1765621

Current Rabies Vaccines Do Not Confer Protective Immunity against Divergent Lyssaviruses Circulating in Europe

Autori: Juan E. Echevarría, Ashley C. Banyard, Lorraine M. McElhinney, Anthony R. Fooks
Pubblicato in: Viruses, Numero 11/10, 2019, Pagina/e 892, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11100892

MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain

Autori: E. Kip, J. Staal, L. Verstrepen, H. G. Tima, S. Terryn, M. Romano, K. Lemeire, V. Suin, A. Hamouda, M. Kalai, R. Beyaert, S. Van Gucht
Pubblicato in: Journal of Virology, Numero 92/8, 2018, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/JVI.02029-17

Utilisation of Chimeric Lyssaviruses to Assess Vaccine Protection against Highly Divergent Lyssaviruses

Autori: Jennifer Evans, Guanghui Wu, David Selden, Hubert Buczkowski, Leigh Thorne, Anthony Fooks, Ashley Banyard
Pubblicato in: Viruses, Numero 10/3, 2018, Pagina/e 130, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10030130

A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice

Autori: Dieudonné B. Kum, Niraj Mishra, Robbert Boudewijns, Ivan Gladwyn-Ng, Christian Alfano, Ji Ma, Michael A. Schmid, Rafael E. Marques, Dominique Schols, Suzanne Kaptein, Laurent Nguyen, Johan Neyts, Kai Dallmeier
Pubblicato in: npj Vaccines, Numero 3/1, 2018, ISSN 2059-0105
Editore: Springer Nature
DOI: 10.1038/s41541-018-0092-2

Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS

Autori: Samuel P. Smith, Guanghui Wu, Anthony R. Fooks, Julian Ma, Ashley C. Banyard
Pubblicato in: Journal of General Virology, Numero 100/8, 2019, Pagina/e 1171-1186, ISSN 0022-1317
Editore: Society for General Microbiology
DOI: 10.1099/jgv.0.001269

Isolation, antigenicity and immunogenicity of Lleida bat lyssavirus

Autori: Ashley C. Banyard, David Selden, Guanghui Wu, Leigh Thorne, Daisy Jennings, Denise Marston, Stefan Finke, Conrad M. Freuling, Thomas Müller, Juan E. Echevarría, Anthony R. Fooks
Pubblicato in: Journal of General Virology, Numero 99/12, 2018, Pagina/e 1590-1599, ISSN 0022-1317
Editore: Society for General Microbiology
DOI: 10.1099/jgv.0.001068

Bats and Viruses: Emergence of Novel Lyssaviruses and Association of Bats with Viral Zoonoses in the EU

Autori: Rebecca Shipley, Edward Wright, David Selden, Guanghui Wu, James Aegerter, Anthony R Fooks, Ashley C Banyard
Pubblicato in: Tropical Medicine and Infectious Disease, Numero 4/1, 2019, Pagina/e 31, ISSN 2414-6366
Editore: Basel
DOI: 10.3390/tropicalmed4010031

Limited evolution of the yellow fever virus 17d in a mouse infection model

Autori: Dieudonné Buh Kum, Niraj Mishra, Bram Vrancken, Hendrik Jan Thibaut, Annelies Wilder-Smith, Philippe Lemey, Johan Neyts, Kai Dallmeier
Pubblicato in: Emerging Microbes & Infections, Numero 8/1, 2019, Pagina/e 1734-1746, ISSN 2222-1751
Editore: Nature Publishing Group
DOI: 10.1080/22221751.2019.1694394

A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice

Autori: Dieudonné Buh Kum, Robbert Boudewijns, Ji Ma, Niraj Mishra, Dominique Schols, Johan Neyts, Kai Dallmeier
Pubblicato in: Emerging Microbes & Infections, Numero 9/1, 2020, Pagina/e 520-533, ISSN 2222-1751
Editore: Nature Publishing Group
DOI: 10.1080/22221751.2020.1730709

Assessing Rabies Vaccine Protection against a Novel Lyssavirus, Kotalahti Bat Lyssavirus

Autori: Rebecca Shipley, Edward Wright, Fabian Z. X. Lean, David Selden, Daniel L. Horton, Anthony R. Fooks, Ashley C. Banyard
Pubblicato in: Viruses, Numero 13/5, 2021, Pagina/e 947, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13050947

Diritti di proprietà intellettuale

Patent (4)

CHIMERIC YELLOW FEVER ZIKA VIRUS STRAIN

Numero candidatura/pubblicazione: 20 18077167
Data: 2018-10-05
Candidato/i: KATHOLIEKE UNIVERSITEIT LEUVEN

CHIMERIC YELLOW FEVER ZIKA VIRUS STRAIN

Numero candidatura/pubblicazione: 20 18077167
Data: 2018-10-05
Candidato/i: KATHOLIEKE UNIVERSITEIT LEUVEN

CHIMERIC FLAVIVIRUS VACCINES

Numero candidatura/pubblicazione: 20 18077156
Data: 2018-10-05
Candidato/i: KATHOLIEKE UNIVERSITEIT LEUVEN

CHIMERIC FLAVIVIRUS VACCINES

Numero candidatura/pubblicazione: 20 18077156
Data: 2018-10-05
Candidato/i: KATHOLIEKE UNIVERSITEIT LEUVEN