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Cerebral Organoids: Using stem cell derived 3D cultures to understand human brain development and neurological disorders

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Publications

Genetically engineered cerebral organoids model brain tumor formation

Author(s): Shan Bian, Marko Repic, Zhenming Guo, Anoop Kavirayani, Thomas Burkard, Joshua A. Bagley, Christian Krauditsch, Jürgen A. Knoblich
Published in: Nature Methods, Issue 15/8, 2018, Page(s) 631-639, ISSN 1548-7091
DOI: 10.1038/s41592-018-0070-7

Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop

Author(s): Sebastian Wissel, Heike Harzer, François Bonnay, Thomas R. Burkard, Ralph A. Neumüller, Juergen A. Knoblich
Published in: The Journal of Cell Biology, 2018, Page(s) jcb.201711167, ISSN 0021-9525
DOI: 10.1083/jcb.201711167

The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells

Author(s): Lisa Landskron, Victoria Steinmann, Francois Bonnay, Thomas R Burkard, Jonas Steinmann, Ilka Reichardt, Heike Harzer, Anne-Sophie Laurenson, Heinrich Reichert, Jürgen A Knoblich
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
DOI: 10.7554/eLife.31347

Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation

Author(s): Nina S. Corsini, Angela M. Peer, Paul Moeseneder, Mykola Roiuk, Thomas R. Burkard, Hans-Christian Theussl, Isabella Moll, Juergen A. Knoblich
Published in: Cell Stem Cell, Issue 22/4, 2018, Page(s) 543-558.e12, ISSN 1934-5909
DOI: 10.1016/j.stem.2018.03.002

Tracing Stem Cell Division in Adult Neurogenesis

Author(s): Nina S. Corsini, Juergen A. Knoblich
Published in: Cell Stem Cell, Issue 22/2, 2018, Page(s) 143-145, ISSN 1934-5909
DOI: 10.1016/j.stem.2018.01.012

Guided self-organization and cortical plate formation in human brain organoids

Author(s): Madeline A Lancaster, Nina S Corsini, Simone Wolfinger, E Hilary Gustafson, Alex W Phillips, Thomas R Burkard, Tomoki Otani, Frederick J Livesey, Juergen A Knoblich
Published in: Nature Biotechnology, Issue 35/7, 2017, Page(s) 659-666, ISSN 1087-0156
DOI: 10.1038/nbt.3906

Fused cerebral organoids model interactions between brain regions

Author(s): Joshua A Bagley, Daniel Reumann, Shan Bian, Julie Lévi-Strauss, Juergen A Knoblich
Published in: Nature Methods, Issue 14/7, 2017, Page(s) 743-751, ISSN 1548-7091
DOI: 10.1038/nmeth.4304

Self‐organized developmental patterning and differentiation in cerebral organoids

Author(s): Magdalena Renner, Madeline A Lancaster, Shan Bian, Heejin Choi, Taeyun Ku, Angela Peer, Kwanghun Chung, Juergen A Knoblich
Published in: The EMBO Journal, Issue 36/10, 2017, Page(s) 1316-1329, ISSN 0261-4189
DOI: 10.15252/embj.201694700

Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding

Author(s): Sven Falk, Stéphane Bugeon, Jovica Ninkovic, Gregor-Alexander Pilz, Maria Pia Postiglione, Harold Cremer, Jürgen A. Knoblich, Magdalena Götz
Published in: Neuron, Issue 93/4, 2017, Page(s) 777-791.e3, ISSN 0896-6273
DOI: 10.1016/j.neuron.2017.02.009

The hope and the hype of organoid research

Author(s): Meritxell Huch, Juergen A. Knoblich, Matthias P. Lutolf, Alfonso Martinez-Arias
Published in: Development, Issue 144/6, 2017, Page(s) 938-941, ISSN 0950-1991
DOI: 10.1242/dev.150201

The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda

Author(s): Ilka Reichardt, François Bonnay, Victoria Steinmann, Inga Loedige, Thomas R Burkard, Gunter Meister, Juergen A Knoblich
Published in: EMBO reports, Issue 19/1, 2017, Page(s) 102-117, ISSN 1469-221X
DOI: 10.15252/embr.201744188