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Cerebral Organoids: Using stem cell derived 3D cultures to understand human brain development and neurological disorders

Publications

ANALYZING THE ROLE OF INTERNEURON MIGRATION IN HUMAN NEUROPSYCHIATRIC DISORDERSUSING FUSED BRAIN ORGANOIDS

Author(s): Bagley JA
Published in: 2019, Page(s) 14
Publisher: BRITISH ASSOCIATION FOR PSYCHOPHARMACOLOGY

Local source of FGF8 orchestrates a cortical fronto-temporal axis in engineered human brain organoids (polaroids)

Author(s): Camilla Bosone
Published in: 2021
Publisher: University of Vienna

CRISPR-LICHT screening in cerebral organoids reveals a regulator of ER secretion as a brain size determinant

Author(s): Dominik Lindenhofer
Published in: 2020
Publisher: University of Vienna

Amplification of human interneuron progenitors promotes brain tumors and neurological defects

Author(s): Eichmüller, OL., Corsini, NS., Vértesy, Á., Morassut, I., Scholl, T., Gruber, VE., Peer, AM., Chu, J., Novatchkova, M., Hainfellner, JA., Paredes, MF., Feucht, M., Knoblich, JA.
Published in: Science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abf5546

Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis

Author(s): Bonnay, F., Veloso, A., Steinmann, V., Köcher, T., Abdusselamoglu, MD., Bajaj, S., Rivelles, E., Landskron, L., Esterbauer, H., Zinzen, RP., Knoblich, JA.
Published in: Cell, 2020, Page(s) 1490-1507.e19, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.07.039

Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration.

Author(s): Sunanjay Bajaj 1 2, Joshua A Bagley 1, Christoph Sommer 3, Abel Vertesy 1, Sakurako Nagumo Wong 1, Veronica Krenn 1, Julie Lévi-Strauss 1, Juergen A Knoblich 1 4
Published in: EMBO J, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021108714

Broad applicability of a streamlined ethyl cinnamate-based clearing procedure

Author(s): Wouter Masselink, Daniel Reumann, Prayag Murawala, Pawel Pasierbek, Yuka Taniguchi, François Bonnay, Katharina Meixner, Jürgen A Knoblich, Elly M Tanaka
Published in: Development, 2019, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.166884

DigiTAG-a RNA Sequencing Approach to Analyze Transcriptomes of Rare Cell Populations in Drosophila melanogaster

Author(s): Lisa Landskron, François Bonnay, Thomas R Burkard, Jürgen A Knoblich
Published in: Bio-protocol, 2020, ISSN 2331-8325
Publisher: Bio-protocol LLC
DOI: 10.21769/bioprotoc.3809

Genetically engineered cerebral organoids model brain tumor formation

Author(s): Shan Bian, Marko Repic, Zhenming Guo, Anoop Kavirayani, Thomas Burkard, Joshua A. Bagley, Christian Krauditsch, Jürgen A. Knoblich
Published in: Nature Methods, Issue 15/8, 2018, Page(s) 631-639, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-018-0070-7

Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop

Author(s): Sebastian Wissel, Heike Harzer, François Bonnay, Thomas R. Burkard, Ralph A. Neumüller, Juergen A. Knoblich
Published in: The Journal of Cell Biology, 2018, Page(s) jcb.201711167, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201711167

The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells

Author(s): Lisa Landskron, Victoria Steinmann, Francois Bonnay, Thomas R Burkard, Jonas Steinmann, Ilka Reichardt, Heike Harzer, Anne-Sophie Laurenson, Heinrich Reichert, Jürgen A Knoblich
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.31347

Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation

Author(s): Nina S. Corsini, Angela M. Peer, Paul Moeseneder, Mykola Roiuk, Thomas R. Burkard, Hans-Christian Theussl, Isabella Moll, Juergen A. Knoblich
Published in: Cell Stem Cell, Issue 22/4, 2018, Page(s) 543-558.e12, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.03.002

Tracing Stem Cell Division in Adult Neurogenesis

Author(s): Nina S. Corsini, Juergen A. Knoblich
Published in: Cell Stem Cell, Issue 22/2, 2018, Page(s) 143-145, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.01.012

Guided self-organization and cortical plate formation in human brain organoids

Author(s): Madeline A Lancaster, Nina S Corsini, Simone Wolfinger, E Hilary Gustafson, Alex W Phillips, Thomas R Burkard, Tomoki Otani, Frederick J Livesey, Juergen A Knoblich
Published in: Nature Biotechnology, Issue 35/7, 2017, Page(s) 659-666, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/nbt.3906

Fused cerebral organoids model interactions between brain regions

Author(s): Joshua A Bagley, Daniel Reumann, Shan Bian, Julie Lévi-Strauss, Juergen A Knoblich
Published in: Nature Methods, Issue 14/7, 2017, Page(s) 743-751, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/nmeth.4304

Self‐organized developmental patterning and differentiation in cerebral organoids

Author(s): Magdalena Renner, Madeline A Lancaster, Shan Bian, Heejin Choi, Taeyun Ku, Angela Peer, Kwanghun Chung, Juergen A Knoblich
Published in: The EMBO Journal, Issue 36/10, 2017, Page(s) 1316-1329, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201694700

The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda

Author(s): Ilka Reichardt, François Bonnay, Victoria Steinmann, Inga Loedige, Thomas R Burkard, Gunter Meister, Juergen A Knoblich
Published in: EMBO reports, Issue 19/1, 2017, Page(s) 102-117, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201744188

A human tissue screen identifies a regulator of ER secretion as a brain-size determinant.

Author(s): "Christopher Esk # 1, Dominik Lindenhofer # 1, Simon Haendeler 1 2, Roelof A Wester 1, Florian Pflug 2, Benoit Schroeder 2, Joshua A Bagley 1, Ulrich Elling 1, Johannes Zuber 3 4, Arndt von Haeseler 2 5, Jürgen A Knoblich 6 4"
Published in: Science, 2020, Page(s) 935-941, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abb5390

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

Author(s): Krenn, V., Bosone, C., Burkard, TR., Spanier, J., Kalinke, U., Calistri, A., Salata, C., Rilo Christoff, R., Pestana Garcez, P., Mirazimi, A., Knoblich, JA.
Published in: Cell Stem Cell, 2021, Page(s) 1362-1379, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.03.004

Intellectual Property Rights

Bi- or multi-differentiated organoid

Application/Publication number: PCT 2018/060559
Date: 2018-04-25

SUPPORTED IN VITRO DEVELOPED TISSUE CULTURE AND CULTURING METHODS

Application/Publication number: EP 17700247
Date: 2017-01-11

Bi- or multi-differentiated organoid

Application/Publication number: PCT 2018/060559
Date: 2018-04-25

SUPPORTED IN VITRO DEVELOPED TISSUE CULTURE AND CULTURING METHODS

Application/Publication number: EP 17700247
Date: 2017-01-11

SUPPORTED IN VITRO DEVELOPED TISSUE CULTURE AND CULTURING METHODS

Application/Publication number: EP 17700247
Date: 2017-01-11

Tumor organoid model

Application/Publication number: PCT 2018/074382
Date: 2018-09-11

Bi- or multi-differentiated organoid

Application/Publication number: PCT 2018/060559
Date: 2018-04-25

Tumor organoid model

Application/Publication number: PCT 2018/074382
Date: 2018-09-11

Tumor organoid model

Application/Publication number: PCT 2018/074382
Date: 2018-09-11

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