Cerebral Organoids: Using stem cell derived 3D cultures to understand human brain development and neurological disorders

Project Information

MiniBrain

Grant agreement ID: 695642

DOI

10.3030/695642

Project closed

EC signature date 13 December 2016

Start date 1 January 2017

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 800 000,00

EU contribution

€ 2 800 000,00

Coordinated by

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Conference proceedings (1)

ANALYZING THE ROLE OF INTERNEURON MIGRATION IN HUMAN NEUROPSYCHIATRIC DISORDERSUSING FUSED BRAIN ORGANOIDS

Author(s): Bagley JA
Published in: 2019, Page(s) 14
Publisher: BRITISH ASSOCIATION FOR PSYCHOPHARMACOLOGY

Thesis and dissertations (2)

Local source of FGF8 orchestrates a cortical fronto-temporal axis in engineered human brain organoids (polaroids)

Author(s): Camilla Bosone
Published in: 2021
Publisher: University of Vienna

CRISPR-LICHT screening in cerebral organoids reveals a regulator of ER secretion as a brain size determinant

Author(s): Dominik Lindenhofer
Published in: 2020
Publisher: University of Vienna

Peer reviewed articles (16)

Amplification of human interneuron progenitors promotes brain tumors and neurological defects

Author(s): Eichmüller, OL., Corsini, NS., Vértesy, Á., Morassut, I., Scholl, T., Gruber, VE., Peer, AM., Chu, J., Novatchkova, M., Hainfellner, JA., Paredes, MF., Feucht, M., Knoblich, JA.
Published in: Science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abf5546

Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis

Author(s): Bonnay, F., Veloso, A., Steinmann, V., Köcher, T., Abdusselamoglu, MD., Bajaj, S., Rivelles, E., Landskron, L., Esterbauer, H., Zinzen, RP., Knoblich, JA.
Published in: Cell, 2020, Page(s) 1490-1507.e19, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.07.039

Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration.

Author(s): Sunanjay Bajaj 1 2, Joshua A Bagley 1, Christoph Sommer 3, Abel Vertesy 1, Sakurako Nagumo Wong 1, Veronica Krenn 1, Julie Lévi-Strauss 1, Juergen A Knoblich 1 4
Published in: EMBO J, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021108714

Broad applicability of a streamlined ethyl cinnamate-based clearing procedure

Author(s): Wouter Masselink, Daniel Reumann, Prayag Murawala, Pawel Pasierbek, Yuka Taniguchi, François Bonnay, Katharina Meixner, Jürgen A Knoblich, Elly M Tanaka
Published in: Development, 2019, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.166884

DigiTAG-a RNA Sequencing Approach to Analyze Transcriptomes of Rare Cell Populations in Drosophila melanogaster

Author(s): Lisa Landskron, François Bonnay, Thomas R Burkard, Jürgen A Knoblich
Published in: Bio-protocol, 2020, ISSN 2331-8325
Publisher: Bio-protocol LLC
DOI: 10.21769/bioprotoc.3809

Genetically engineered cerebral organoids model brain tumor formation

Author(s): Shan Bian, Marko Repic, Zhenming Guo, Anoop Kavirayani, Thomas Burkard, Joshua A. Bagley, Christian Krauditsch, Jürgen A. Knoblich
Published in: Nature Methods, Issue 15/8, 2018, Page(s) 631-639, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-018-0070-7

Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop

Author(s): Sebastian Wissel, Heike Harzer, François Bonnay, Thomas R. Burkard, Ralph A. Neumüller, Juergen A. Knoblich
Published in: The Journal of Cell Biology, 2018, Page(s) jcb.201711167, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201711167

The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells

Author(s): Lisa Landskron, Victoria Steinmann, Francois Bonnay, Thomas R Burkard, Jonas Steinmann, Ilka Reichardt, Heike Harzer, Anne-Sophie Laurenson, Heinrich Reichert, Jürgen A Knoblich
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.31347

Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation

Author(s): Nina S. Corsini, Angela M. Peer, Paul Moeseneder, Mykola Roiuk, Thomas R. Burkard, Hans-Christian Theussl, Isabella Moll, Juergen A. Knoblich
Published in: Cell Stem Cell, Issue 22/4, 2018, Page(s) 543-558.e12, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.03.002

Tracing Stem Cell Division in Adult Neurogenesis

Author(s): Nina S. Corsini, Juergen A. Knoblich
Published in: Cell Stem Cell, Issue 22/2, 2018, Page(s) 143-145, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.01.012

Guided self-organization and cortical plate formation in human brain organoids

Author(s): Madeline A Lancaster, Nina S Corsini, Simone Wolfinger, E Hilary Gustafson, Alex W Phillips, Thomas R Burkard, Tomoki Otani, Frederick J Livesey, Juergen A Knoblich
Published in: Nature Biotechnology, Issue 35/7, 2017, Page(s) 659-666, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/nbt.3906

Fused cerebral organoids model interactions between brain regions

Author(s): Joshua A Bagley, Daniel Reumann, Shan Bian, Julie Lévi-Strauss, Juergen A Knoblich
Published in: Nature Methods, Issue 14/7, 2017, Page(s) 743-751, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/nmeth.4304

Self‐organized developmental patterning and differentiation in cerebral organoids

Author(s): Magdalena Renner, Madeline A Lancaster, Shan Bian, Heejin Choi, Taeyun Ku, Angela Peer, Kwanghun Chung, Juergen A Knoblich
Published in: The EMBO Journal, Issue 36/10, 2017, Page(s) 1316-1329, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201694700

The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda

Author(s): Ilka Reichardt, François Bonnay, Victoria Steinmann, Inga Loedige, Thomas R Burkard, Gunter Meister, Juergen A Knoblich
Published in: EMBO reports, Issue 19/1, 2017, Page(s) 102-117, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201744188

A human tissue screen identifies a regulator of ER secretion as a brain-size determinant.

Author(s): "Christopher Esk # 1, Dominik Lindenhofer # 1, Simon Haendeler 1 2, Roelof A Wester 1, Florian Pflug 2, Benoit Schroeder 2, Joshua A Bagley 1, Ulrich Elling 1, Johannes Zuber 3 4, Arndt von Haeseler 2 5, Jürgen A Knoblich 6 4"
Published in: Science, 2020, Page(s) 935-941, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abb5390

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

Author(s): Krenn, V., Bosone, C., Burkard, TR., Spanier, J., Kalinke, U., Calistri, A., Salata, C., Rilo Christoff, R., Pestana Garcez, P., Mirazimi, A., Knoblich, JA.
Published in: Cell Stem Cell, 2021, Page(s) 1362-1379, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.03.004

Intellectual Property Rights

Patent (3)

Bi- or multi-differentiated organoid

Application/Publication number: PCT 2018/060559
Date: 2018-04-25
Applicant(s): INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH

Tumor organoid model

Application/Publication number: PCT 2018/074382
Date: 2018-09-11
Applicant(s): INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH

SUPPORTED IN VITRO DEVELOPED TISSUE CULTURE AND CULTURING METHODS

Application/Publication number: EP 17700247
Date: 2017-01-11
Applicant(s): INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH