Cerebral Organoids: Using stem cell derived 3D cultures to understand human brain development and neurological disorders

Publicaciones

ANALYZING THE ROLE OF INTERNEURON MIGRATION IN HUMAN NEUROPSYCHIATRIC DISORDERSUSING FUSED BRAIN ORGANOIDS

Autores: Bagley JA
Publicado en: 2019, Página(s) 14
Editor: BRITISH ASSOCIATION FOR PSYCHOPHARMACOLOGY

Local source of FGF8 orchestrates a cortical fronto-temporal axis in engineered human brain organoids (polaroids)

Autores: Camilla Bosone
Publicado en: 2021
Editor: University of Vienna

CRISPR-LICHT screening in cerebral organoids reveals a regulator of ER secretion as a brain size determinant

Autores: Dominik Lindenhofer
Publicado en: 2020
Editor: University of Vienna

Amplification of human interneuron progenitors promotes brain tumors and neurological defects

Autores: Eichmüller, OL., Corsini, NS., Vértesy, Á., Morassut, I., Scholl, T., Gruber, VE., Peer, AM., Chu, J., Novatchkova, M., Hainfellner, JA., Paredes, MF., Feucht, M., Knoblich, JA.
Publicado en: Science, 2022, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abf5546

Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis

Autores: Bonnay, F., Veloso, A., Steinmann, V., Köcher, T., Abdusselamoglu, MD., Bajaj, S., Rivelles, E., Landskron, L., Esterbauer, H., Zinzen, RP., Knoblich, JA.
Publicado en: Cell, 2020, Página(s) 1490-1507.e19, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.07.039

Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration.

Autores: Sunanjay Bajaj 1 2, Joshua A Bagley 1, Christoph Sommer 3, Abel Vertesy 1, Sakurako Nagumo Wong 1, Veronica Krenn 1, Julie Lévi-Strauss 1, Juergen A Knoblich 1 4
Publicado en: EMBO J, 2021, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2021108714

Broad applicability of a streamlined ethyl cinnamate-based clearing procedure

Autores: Wouter Masselink, Daniel Reumann, Prayag Murawala, Pawel Pasierbek, Yuka Taniguchi, François Bonnay, Katharina Meixner, Jürgen A Knoblich, Elly M Tanaka
Publicado en: Development, 2019, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.166884

DigiTAG-a RNA Sequencing Approach to Analyze Transcriptomes of Rare Cell Populations in Drosophila melanogaster

Autores: Lisa Landskron, François Bonnay, Thomas R Burkard, Jürgen A Knoblich
Publicado en: Bio-protocol, 2020, ISSN 2331-8325
Editor: Bio-protocol LLC
DOI: 10.21769/bioprotoc.3809

Genetically engineered cerebral organoids model brain tumor formation

Autores: Shan Bian, Marko Repic, Zhenming Guo, Anoop Kavirayani, Thomas Burkard, Joshua A. Bagley, Christian Krauditsch, Jürgen A. Knoblich
Publicado en: Nature Methods, Edición 15/8, 2018, Página(s) 631-639, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41592-018-0070-7

Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop

Autores: Sebastian Wissel, Heike Harzer, François Bonnay, Thomas R. Burkard, Ralph A. Neumüller, Juergen A. Knoblich
Publicado en: The Journal of Cell Biology, 2018, Página(s) jcb.201711167, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201711167

The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells

Autores: Lisa Landskron, Victoria Steinmann, Francois Bonnay, Thomas R Burkard, Jonas Steinmann, Ilka Reichardt, Heike Harzer, Anne-Sophie Laurenson, Heinrich Reichert, Jürgen A Knoblich
Publicado en: eLife, Edición 7, 2018, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.31347

Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation

Autores: Nina S. Corsini, Angela M. Peer, Paul Moeseneder, Mykola Roiuk, Thomas R. Burkard, Hans-Christian Theussl, Isabella Moll, Juergen A. Knoblich
Publicado en: Cell Stem Cell, Edición 22/4, 2018, Página(s) 543-558.e12, ISSN 1934-5909
Editor: Cell Press
DOI: 10.1016/j.stem.2018.03.002

Tracing Stem Cell Division in Adult Neurogenesis

Autores: Nina S. Corsini, Juergen A. Knoblich
Publicado en: Cell Stem Cell, Edición 22/2, 2018, Página(s) 143-145, ISSN 1934-5909
Editor: Cell Press
DOI: 10.1016/j.stem.2018.01.012

Guided self-organization and cortical plate formation in human brain organoids

Autores: Madeline A Lancaster, Nina S Corsini, Simone Wolfinger, E Hilary Gustafson, Alex W Phillips, Thomas R Burkard, Tomoki Otani, Frederick J Livesey, Juergen A Knoblich
Publicado en: Nature Biotechnology, Edición 35/7, 2017, Página(s) 659-666, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/nbt.3906

Fused cerebral organoids model interactions between brain regions

Autores: Joshua A Bagley, Daniel Reumann, Shan Bian, Julie Lévi-Strauss, Juergen A Knoblich
Publicado en: Nature Methods, Edición 14/7, 2017, Página(s) 743-751, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/nmeth.4304

Self‐organized developmental patterning and differentiation in cerebral organoids

Autores: Magdalena Renner, Madeline A Lancaster, Shan Bian, Heejin Choi, Taeyun Ku, Angela Peer, Kwanghun Chung, Juergen A Knoblich
Publicado en: The EMBO Journal, Edición 36/10, 2017, Página(s) 1316-1329, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.201694700

The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda

Autores: Ilka Reichardt, François Bonnay, Victoria Steinmann, Inga Loedige, Thomas R Burkard, Gunter Meister, Juergen A Knoblich
Publicado en: EMBO reports, Edición 19/1, 2017, Página(s) 102-117, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.201744188

A human tissue screen identifies a regulator of ER secretion as a brain-size determinant.

Autores: "Christopher Esk # 1, Dominik Lindenhofer # 1, Simon Haendeler 1 2, Roelof A Wester 1, Florian Pflug 2, Benoit Schroeder 2, Joshua A Bagley 1, Ulrich Elling 1, Johannes Zuber 3 4, Arndt von Haeseler 2 5, Jürgen A Knoblich 6 4"
Publicado en: Science, 2020, Página(s) 935-941, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abb5390

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

Autores: Krenn, V., Bosone, C., Burkard, TR., Spanier, J., Kalinke, U., Calistri, A., Salata, C., Rilo Christoff, R., Pestana Garcez, P., Mirazimi, A., Knoblich, JA.
Publicado en: Cell Stem Cell, 2021, Página(s) 1362-1379, ISSN 1934-5909
Editor: Cell Press
DOI: 10.1016/j.stem.2021.03.004

Derechos de propiedad intelectual

Bi- or multi-differentiated organoid

Número de solicitud/publicación: PCT 2018/060559
Fecha: 2018-04-25

SUPPORTED IN VITRO DEVELOPED TISSUE CULTURE AND CULTURING METHODS

Número de solicitud/publicación: EP 17700247
Fecha: 2017-01-11

Bi- or multi-differentiated organoid

Número de solicitud/publicación: PCT 2018/060559
Fecha: 2018-04-25

SUPPORTED IN VITRO DEVELOPED TISSUE CULTURE AND CULTURING METHODS

Número de solicitud/publicación: EP 17700247
Fecha: 2017-01-11

SUPPORTED IN VITRO DEVELOPED TISSUE CULTURE AND CULTURING METHODS

Número de solicitud/publicación: EP 17700247
Fecha: 2017-01-11

Tumor organoid model

Número de solicitud/publicación: PCT 2018/074382
Fecha: 2018-09-11

Bi- or multi-differentiated organoid

Número de solicitud/publicación: PCT 2018/060559
Fecha: 2018-04-25

Tumor organoid model

Número de solicitud/publicación: PCT 2018/074382
Fecha: 2018-09-11

Tumor organoid model

Número de solicitud/publicación: PCT 2018/074382
Fecha: 2018-09-11

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Publicaciones

Derechos de propiedad intelectual

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