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Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research

Deliverables

Standardized work-flows for integrative sample preparation methods for structural biology in cells

Standardized work-flows for integrative sample preparation methods for structural biology in cells

Process plan for raw and metadata archiving in subtask 8.1.2

Process plan for raw and metadata archiving in subtask 8.1.2

Prototype process for data transfer defined in subtask 8.1.1

Prototype process for data transfer defined in subtask 8.1.1

Plan a programme for review of Instruct infrastructure with external review panel

Plan a programme for review of Instruct infrastructure with external review panel

Process for establishing joint activities with new countries and formalising an agreement defining the shared programme

Process for establishing joint activities with new countries and formalising an agreement defining the shared programme

Training programme for core facility and Instruct Centre staff

Training programme for core facility and Instruct Centre staff

Dissemination, outreach and exploitation plan submitted to Executive Committee for review

Dissemination, outreach and exploitation plan submitted to Executive Committee for review

Standardized work-flows for extending the use of nanobodies

Standardized work-flows for extending the use of nanobodies

Public list of services offered to industries

Public list of services offered to industries

Standardized work-flows for production, crystallization and data collection of membrane protein

Standardized work-flows for production, crystallization and data collection of membrane protein

Publication of a position paper on the operation of NMR services and RIs in general as a guide for users in collaboration with WP3

Publication of a position paper on the operation of NMR services and RIs in general as a guide for users in collaboration with WP3

Schedule of events to engage widely with key stakeholders

Schedule of events to engage widely with key stakeholders

Women in Science workshop

Women in Science workshop

Outreach programme for new academic communities including an information pack

Outreach programme for new academic communities including an information pack

Call 1 launched for developing new service provision of existing technologies and selection of qualifying projects

Call 1 launched for developing new service provision of existing technologies and selection of qualifying projects

Searching for OpenAIRE data...

Publications

Fast simulations of multidimensional NMR spectra of proteins and peptides


Published in: ISSN 0749-1581
DOI: 10.1002/mrc.4663

Volta phase plate data collection facilitates image processing and cryo-EM structure determination

Author(s): Ottilie von Loeffelholz, Gabor Papai, Radostin Danev, Alexander G. Myasnikov, S. Kundhavai Natchiar, Isabelle Hazemann, Jean-François Ménétret, Bruno P. Klaholz
Published in: Journal of Structural Biology, Issue 202/3, 2018, Page(s) 191-199, ISSN 1047-8477
DOI: 10.1016/j.jsb.2018.01.003

Visualization of chemical modifications in the human 80S ribosome structure

Author(s): S. Kundhavai Natchiar, Alexander G. Myasnikov, Hanna Kratzat, Isabelle Hazemann, Bruno P. Klaholz
Published in: Nature, 2017, ISSN 0028-0836
DOI: 10.1038/nature24482

Function and Interactions of ERCC1-XPF in DNA Damage Response

Author(s): Maryam Faridounnia, Gert Folkers, Rolf Boelens
Published in: Molecules, Issue 23/12, 2018, Page(s) 3205, ISSN 1420-3049
DOI: 10.3390/molecules23123205

Real-Time Insights into Biological Events: In-Cell Processes and Protein-Ligand Interactions

Author(s): Linda Cerofolini, Stefano Giuntini, Letizia Barbieri, Matteo Pennestri, Anna Codina, Marco Fragai, Lucia Banci, Enrico Luchinat, Enrico Ravera
Published in: Biophysical Journal, Issue 116/2, 2019, Page(s) 239-247, ISSN 0006-3495
DOI: 10.1016/j.bpj.2018.11.3132

Validation of electron microscopy initial models via small angle X-ray scattering curves

Author(s): Amaya Jiménez, Slavica Jonic, Tomas Majtner, Joaquín Otón, Jose Luis Vilas, David Maluenda, Javier Mota, Erney Ramírez-Aportela, Marta Martínez, Yaiza Rancel, Joan Segura, Ruben Sánchez-García, Roberto Melero, Laura del Cano, Pablo Conesa, Lars Skjaerven, Roberto Marabini, Jose M Carazo, Carlos Oscar S Sorzano
Published in: Bioinformatics, Issue 35/14, 2018, Page(s) 2427-2433, ISSN 1367-4803
DOI: 10.1093/bioinformatics/bty985

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

Author(s): Haitian Fan, Alexander P. Walker, Loïc Carrique, Jeremy R. Keown, Itziar Serna Martin, Dimple Karia, Jane Sharps, Narin Hengrung, Els Pardon, Jan Steyaert, Jonathan M. Grimes, Ervin Fodor
Published in: Nature, Issue 573/7773, 2019, Page(s) 287-290, ISSN 0028-0836
DOI: 10.1038/s41586-019-1530-7

CENP-A nucleosome clusters form rosette-like structures around HJURP during G1

Author(s): Leonid Andronov, Khalid Ouararhni, Isabelle Stoll, Bruno P. Klaholz, Ali Hamiche
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-12383-3

Deriving and refining atomic models in crystallography and cryo-EM: the latest Phenix tools to facilitate structure analysis

Author(s): Bruno P. Klaholz
Published in: Acta Crystallographica Section D Structural Biology, Issue 75/10, 2019, Page(s) 878-881, ISSN 2059-7983
DOI: 10.1107/s2059798319013391

Flexible workflows for on-the-fly electron-microscopy single-particle image processing using Scipion

Author(s): D. Maluenda, T. Majtner, P. Horvath, J. L. Vilas, A. Jiménez-Moreno, J. Mota, E. Ramírez-Aportela, R. Sánchez-García, P. Conesa, L. del Caño, Y. Rancel, Y. Fonseca, M. Martínez, G. Sharov, C.A. García, D. Strelak, R. Melero, R. Marabini, J. M. Carazo, C. O. S. Sorzano
Published in: Acta Crystallographica Section D Structural Biology, Issue 75/10, 2019, Page(s) 882-894, ISSN 2059-7983
DOI: 10.1107/s2059798319011860

DeepRes : a new deep-learning- and aspect-based local resolution method for electron-microscopy maps

Author(s): Erney Ramírez-Aportela, Javier Mota, Pablo Conesa, Jose Maria Carazo, Carlos Oscar S. Sorzano
Published in: IUCrJ, Issue 6/6, 2019, Page(s) 1054-1063, ISSN 2052-2525
DOI: 10.1107/s2052252519011692

On the complementarity of X-ray and NMR data

Author(s): Antonio Schirò, Azzurra Carlon, Giacomo Parigi, Garib Murshudov, Vito Calderone, Enrico Ravera, Claudio Luchinat
Published in: Journal of Structural Biology: X, Issue 4, 2020, Page(s) 100019, ISSN 2590-1524
DOI: 10.1016/j.yjsbx.2020.100019

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

Author(s): Tomasz Uchański, Simonas Masiulis, Baptiste Fischer, Valentina Kalichuk, Alexandre Wohlkönig, Thomas Zögg, Han Remaut, Wim Vranken, A. Radu Aricescu, Els Pardon, Jan Steyaert
Published in: bioRxiv, 2019
DOI: 10.1101/812230

MicrographCleaner: a python package for cryo-EM micrograph segmentation using deep learning.

Author(s): Sanchez-Garcia R, Segura J, Maluenda D, Sorzano CO, Carazo JM.
Published in: bioRxiv, 2019

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.

Author(s): Uchanski T, Masiulis S, Fischer B, Kalichuk V, Wohlkonig A, Zogg T, Remaut H, Vranken W, Aricescu AR, Pardon E, Steyaert J.
Published in: bioRxiv, 2019

TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair

Author(s): Olga Kolesnikova, Laura Radu, Arnaud Poterszman
Published in: DNA Repair, Issue 115, 2019, Page(s) 21-67
DOI: 10.1016/bs.apcsb.2019.01.003