CORDIS
EU research results

CORDIS

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Epilepsy Controlled with Electronic Neurotransmitter Delivery

Project information

Grant agreement ID: 716867

Status

Ongoing project

  • Start date

    1 March 2017

  • End date

    28 February 2022

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 636 250

  • EU contribution

    € 1 636 250

Hosted by:

UNIVERSITE D'AIX MARSEILLE

France

Objective

Many efficient drugs have been designed to treat neurological disorders, but have failed in the clinic because they were toxic, could not cross the blood-brain barrier, and/or had deleterious side effects in healthy regions. I propose a conceptual breakthrough to solve these three issues, with minimally-invasive organic electronic ion pumps (OEIPs) to provide targeted treatment where and when it is needed. I will use epilepsy as the disease model because of its high rate of drug-resistance (30%) and will offer concrete opportunities for clinical transfer of such state-of-the-art technology.
The clinical problem: Resective surgery is frequently the last option available to a patient with drug-resistant epilepsy (> 1 million persons in the EU). However, surgery fails in 30% of the cases and can have deleterious consequences with severe postoperative neurological deficits (impaired motor function, speech and memory). Furthermore, some cases of epilepsy are simply untreatable surgically because resective surgery would leave unacceptable damage to core functions. Clearly, a new therapeutic approach is needed when neurosurgery is not possible or deemed too risky.
The OEIP solution: As I have demonstrated, OEIPs combine state-of-the-art organic electronics and pharmacology to control epileptiform activity in vitro by directly delivering inhibitory neurotransmitters on-demand. I additionally demonstrated that thin-film flexible organic electronics can be used to create minimally-invasive depth probes for implantation which significantly reduced tissue damage compared to standard rigid implants in vivo. I will integrate OEIPs on such probes creating devices which will have both the high-quality recordings provided by the organic electrodes for electrophysiological seizure detection and the molecular delivery capability of the OEIP for seizure intervention. The devices will be a closed-loop system to detect seizure onset and intervene in the affected brain region.

Host institution

UNIVERSITE D'AIX MARSEILLE

Address

Boulevard Charles Livon 58
13284 Marseille

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 636 250

Beneficiaries (1)

UNIVERSITE D'AIX MARSEILLE

France

EU Contribution

€ 1 636 250

Project information

Grant agreement ID: 716867

Status

Ongoing project

  • Start date

    1 March 2017

  • End date

    28 February 2022

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 636 250

  • EU contribution

    € 1 636 250

Hosted by:

UNIVERSITE D'AIX MARSEILLE

France