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The Chemical Basis of RNA Epigenetics

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Publications

Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis

Author(s): Sidney Becker, Christina Schneider, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Milan Dejmek, Thomas Carell
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-017-02639-1

Non-canonical nucleosides and chemistry of the emergence of life

Author(s): Sidney Becker, Christina Schneider, Antony Crisp, Thomas Carell
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-07222-w

5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo

Author(s): Katharina Iwan, René Rahimoff, Angie Kirchner, Fabio Spada, Arne S Schröder, Olesea Kosmatchev, Shqiponja Ferizaj, Jessica Steinbacher, Edris Parsa, Markus Müller, Thomas Carell
Published in: Nature Chemical Biology, Issue 14/1, 2018, Page(s) 72-78, ISSN 1552-4450
DOI: 10.1038/nchembio.2531

A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions

Author(s): Hidenori Okamura, Sidney Becker, Niklas Tiede, Stefan Wiedemann, Jonas Feldmann, Thomas Carell
Published in: Chemical Communications, Issue 55/13, 2019, Page(s) 1939-1942, ISSN 1359-7345
DOI: 10.1039/c8cc09435g

Synthesis and Incorporation of k 2 U into RNA

Author(s): Milda Nainyte, Thomas Carell
Published in: Helvetica Chimica Acta, Issue 103/3, 2020, ISSN 0018-019X
DOI: 10.1002/hlca.202000016

TLR8 Is a Sensor of RNase T2 Degradation Products

Author(s): Wilhelm Greulich, Mirko Wagner, Moritz M. Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung
Published in: Cell, Issue 179/6, 2019, Page(s) 1264-1275.e13, ISSN 0092-8674
DOI: 10.1016/j.cell.2019.11.001

A Click‐Chemistry Linked 2′3′‐cGAMP Analogue


Published in: ISSN 0947-6539
DOI: 10.1002/chem.201805409

Proto‐Urea‐RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides


Published in: ISSN 1433-7851
DOI: 10.1002/anie.201911746

ALKBH5-induced demethylation of mono- and dimethylated adenosine

Author(s): Timm T. Ensfelder, Matthias Q. Kurz, Katharina Iwan, Simon Geiger, Sarah Matheisl, Markus Müller, Roland Beckmann, Thomas Carell
Published in: Chemical Communications, Issue 54/62, 2018, Page(s) 8591-8593, ISSN 1359-7345
DOI: 10.1039/c8cc03980a

Synthesis of an acp 3 U phosphoramidite and incorporation of the hypermodified base into RNA

Author(s): Milda Nainytė, Tynchtyk Amatov, Thomas Carell
Published in: Chemical Communications, Issue 55/81, 2019, Page(s) 12216-12218, ISSN 1359-7345
DOI: 10.1039/c9cc06314e

Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides

Author(s): Sidney Becker, Jonas Feldmann, Stefan Wiedemann, Hidenori Okamura, Christina Schneider, Katharina Iwan, Antony Crisp, Martin Rossa, Tynchtyk Amatov, Thomas Carell
Published in: Science, Issue 366/6461, 2019, Page(s) 76-82, ISSN 0036-8075
DOI: 10.1126/science.aax2747