Skip to main content

The Chemical Basis of RNA Epigenetics

Publications

Active turnover of genomic methylcytosine in pluripotent cells

Author(s): Fabio Spada, Sarah Schiffers, Angie Kirchner, Yingqian Zhang, Gautier Arista, Olesea Kosmatchev, Eva Korytiakova, René Rahimoff, Charlotte Ebert, Thomas Carell
Published in: Nature Chemical Biology, Issue 16/12, 2020, Page(s) 1411-1419, ISSN 1552-4450
DOI: 10.1038/s41589-020-0621-y

Impact of 5-formylcytosine on the melting kinetics of DNA by 1H NMR chemical exchange

Author(s): Romeo C A Dubini, Alexander Schön, Markus Müller, Thomas Carell, and Petra Rovó
Published in: Nucleic Acids Research, Issue 48, 2020, Page(s) 8796-8807, ISSN 1362-4962
DOI: 10.1093/nar/gkaa589

Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis

Author(s): Sidney Becker, Christina Schneider, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Milan Dejmek, Thomas Carell
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-017-02639-1

Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth-Generation by Prebiotic Methylations and Carbamoylations

Author(s): Christina Schneider, Sidney Becker, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Michael Stadlmeier, Thomas Carell
Published in: Angewandte Chemie International Edition, Issue 57/20, 2018, Page(s) 5943-5946, ISSN 1433-7851
DOI: 10.1002/anie.201801919

Non-canonical nucleosides and chemistry of the emergence of life

Author(s): Sidney Becker, Christina Schneider, Antony Crisp, Thomas Carell
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-07222-w

5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo

Author(s): Katharina Iwan, René Rahimoff, Angie Kirchner, Fabio Spada, Arne S Schröder, Olesea Kosmatchev, Shqiponja Ferizaj, Jessica Steinbacher, Edris Parsa, Markus Müller, Thomas Carell
Published in: Nature Chemical Biology, Issue 14/1, 2018, Page(s) 72-78, ISSN 1552-4450
DOI: 10.1038/nchembio.2531

A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions

Author(s): Hidenori Okamura, Sidney Becker, Niklas Tiede, Stefan Wiedemann, Jonas Feldmann, Thomas Carell
Published in: Chemical Communications, Issue 55/13, 2019, Page(s) 1939-1942, ISSN 1359-7345
DOI: 10.1039/c8cc09435g

Super-sensitive multi-fluorophore RNA-FISH for early virus detection and flow-FISH using click chemistry

Author(s): Nada Raddaoui, Stefano Groce, Florian Geiger, Alexander Borodavka, Leonhard Möckl, Samuele Stazzoni, Bastien Viverge, Christoph Bräuchle, Thomas Frischmuth, Hanna Engelke, Thomas Carell
Published in: ChemBioChem, Issue 18.03.2020, 2020, ISSN 1439-4227
DOI: 10.1002/cbic.202000081

Synthesis and Incorporation of k 2 U into RNA

Author(s): Milda Nainyte, Thomas Carell
Published in: Helvetica Chimica Acta, Issue 103/3, 2020, ISSN 0018-019X
DOI: 10.1002/hlca.202000016

TLR8 Is a Sensor of RNase T2 Degradation Products

Author(s): Wilhelm Greulich, Mirko Wagner, Moritz M. Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung
Published in: Cell, Issue 179/6, 2019, Page(s) 1264-1275.e13, ISSN 0092-8674
DOI: 10.1016/j.cell.2019.11.001

A Click‐Chemistry Linked 2′3′‐cGAMP Analogue

Author(s): Clemens Reto Dialer, Samuele Stazzoni, David Jan Drexler, Felix Moritz Müller, Simon Veth, Alexander Pichler, Hidenori Okamura, Gregor Witte, Karl‐Peter Hopfner, Thomas Carell
Published in: Chemistry – A European Journal, Issue 25/8, 2019, Page(s) 2089-2095, ISSN 0947-6539
DOI: 10.1002/chem.201805409

Proto‐Urea‐RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides

Author(s): Hidenori Okamura, Antony Crisp, Sarah Hübner, Sidney Becker, Petra Rovó, Thomas Carell
Published in: Angewandte Chemie International Edition, Issue 58/51, 2019, Page(s) 18691-18696, ISSN 1433-7851
DOI: 10.1002/anie.201911746

A Click‐Chemistry‐Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry

Author(s): Michael Stadlmeier, Leander Simon Runtsch, Filipp Streshnev, Martin Wühr, Thomas Carell
Published in: ChemBioChem, Issue 21/1-2, 2019, Page(s) 103-107, ISSN 1439-4227
DOI: 10.1002/cbic.201900611

Influencing Epigenetic Information with a Hydrolytically Stable Carbocyclic 5‐Aza‐2′‐deoxycytidine

Author(s): Thomas M. Wildenhof, Sarah Schiffers, Franziska R. Traube, Peter Mayer, Thomas Carell
Published in: Angewandte Chemie International Edition, Issue 58/37, 2019, Page(s) 12984-12987, ISSN 1433-7851
DOI: 10.1002/anie.201904794

ALKBH5-induced demethylation of mono- and dimethylated adenosine

Author(s): Timm T. Ensfelder, Matthias Q. Kurz, Katharina Iwan, Simon Geiger, Sarah Matheisl, Markus Müller, Roland Beckmann, Thomas Carell
Published in: Chemical Communications, Issue 54/62, 2018, Page(s) 8591-8593, ISSN 1359-7345
DOI: 10.1039/c8cc03980a

Synthesis of an acp 3 U phosphoramidite and incorporation of the hypermodified base into RNA

Author(s): Milda Nainytė, Tynchtyk Amatov, Thomas Carell
Published in: Chemical Communications, Issue 55/81, 2019, Page(s) 12216-12218, ISSN 1359-7345
DOI: 10.1039/c9cc06314e

Synthesis of galactosyl‐queuosine and distribution of hypermodified Q‐nucleosides in mouse tissues

Author(s): Peter Thumbs, Timm T. Ensfelder, Markus Hillmeier, Mirko Wagner, Matthias Heiss, Constanze Scheel, Alexander Schön, Markus Müller, Stylianos Michalakis, Stefanie Kellner, Thomas Carell
Published in: Angewandte Chemie International Edition, Issue 11.03.2020, 2020, ISSN 1433-7851
DOI: 10.1002/anie.202002295

Analysis of an Active Deformylation Mechanism of 5‐Formyl‐deoxycytidine (fdC) in Stem Cells

Author(s): Alexander Schön, Ewelina Kaminska, Florian Schelter, Eveliina Ponkkonen, Eva Korytiaková, Sarah Schiffers, Thomas Carell
Published in: Angewandte Chemie International Edition, Issue 59/14, 2020, Page(s) 5591-5594, ISSN 1433-7851
DOI: 10.1002/anie.202000414

Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides

Author(s): Sidney Becker, Jonas Feldmann, Stefan Wiedemann, Hidenori Okamura, Christina Schneider, Katharina Iwan, Antony Crisp, Martin Rossa, Tynchtyk Amatov, Thomas Carell
Published in: Science, Issue 366/6461, 2019, Page(s) 76-82, ISSN 0036-8075
DOI: 10.1126/science.aax2747

Datasets

CCDC 1574223: Experimental Crystal Structure Determination

Author(s): Becker, Sidney; Schneider, Christina; Okamura, Hidenori; Crisp, Antony; Amatov, Tynchtyk; Dejmek, Milan; Carell, Thomas
Published in: Cambridge Crystallographic Data Centre

CCDC 1574225: Experimental Crystal Structure Determination

Author(s): Becker, Sidney; Schneider, Christina; Okamura, Hidenori; Crisp, Antony; Amatov, Tynchtyk; Dejmek, Milan; Carell, Thomas
Published in: Cambridge Crystallographic Data Centre

CCDC 1574224: Experimental Crystal Structure Determination

Author(s): Becker, Sidney; Schneider, Christina; Okamura, Hidenori; Crisp, Antony; Amatov, Tynchtyk; Dejmek, Milan; Carell, Thomas
Published in: Cambridge Crystallographic Data Centre

CCDC 1574226: Experimental Crystal Structure Determination

Author(s): Becker, Sidney; Schneider, Christina; Okamura, Hidenori; Crisp, Antony; Amatov, Tynchtyk; Dejmek, Milan; Carell, Thomas
Published in: Cambridge Crystallographic Data Centre