The Chemical Basis of RNA Epigenetics

Pubblicazioni

Active turnover of genomic methylcytosine in pluripotent cells

Autori: Fabio Spada, Sarah Schiffers, Angie Kirchner, Yingqian Zhang, Gautier Arista, Olesea Kosmatchev, Eva Korytiakova, René Rahimoff, Charlotte Ebert, Thomas Carell
Pubblicato in: Nature Chemical Biology, Numero 16/12, 2020, Pagina/e 1411-1419, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-020-0621-y

A prebiotically plausible scenario of an RNA–peptide world

Autori: Felix Müller, Luis Escobar, Felix Xu, Ewa Wegrzyn, Milda Nainyte, Tynchtyk Amatov, Chun-Yin Chan, Alexander Pichler, Thomas Carell
Pubblicato in: Nature, Numero 605, 2022, Pagina/e 279-284, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-04676-3

Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World.

Autori: Milda Nainytė; Felix Müller; Giacomo Ganazzoli; Chun-Yin Chan; Antony Crisp; Daniel Globisch; Thomas Carell
Pubblicato in: Chemistry, A European Journal, Numero 26(65), 2020, Pagina/e 14856-14860, ISSN 1521-3765
Editore: Wiley-VCH GmbH
DOI: 10.1002/chem.202002929

Human TRMT2A methylates tRNA and contributes to translation fidelity

Autori: Monika Witzenberger, Sandra Burczyk, David Settele, Wieland Mayer, Luisa M Welp, Matthias Heiss, Mirko Wagner, Thomas Monecke, Robert Janowski, Thomas Carell, Henning Urlaub, Stefanie M Hauck, Aaron Voigt, and Dierk Niessing
Pubblicato in: Nucleic Acids Research, Numero 51(16), 2023, Pagina/e 8691-8710, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkad565

1H NMR Chemical Exchange Techniques Reveal Local and Global Effects of Oxidized Cytosine Derivatives

Autori: Romeo C.A. Dubini, Eva Korytiaková, Thea Schinkel, Pia Heinrichs, Thomas Carell, Petra Rovó
Pubblicato in: ACS Physical Chemistry Au, Numero 2(3), 2022, Pagina/e 237-246, ISSN 2694-2445
Editore: ACS Publications
DOI: 10.1021/acsphyschemau.1c00050

Synthesis and Structure Elucidation of Glutamyl-Queuosine

Autori: Alexander Pichler, Markus Hillmeier, Matthias Heiss, Elsa Peev, Stylianos Xefteris, Barbara Steigenberger, Ines Thoma, Markus Müller, Marco Borsò, Axel Imhof, and Thomas Carell
Pubblicato in: Journal of the American Chemical Society, Numero 145(47), 2023, Pagina/e 25528-25532, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c10075

Epigenetic Anti-Cancer Treatment With a Stabilized Carbocyclic Decitabine Analogue

Autori: Franziska R. Traube, Natércia F. Brás, Dr. Wynand P. Roos, Corinna C. Sommermann, Tamara Diehl, Robert J. Mayer, Armin R. Ofial, Markus Müller, Hendrik Zipse, Thomas Carell
Pubblicato in: Chemistry - A European Journal, Numero Early View, 2022, Pagina/e e202200640, ISSN 1521-3765
Editore: Wiley-VCH
DOI: 10.1002/chem.202200640

Synthesis and structure elucidation of the human tRNA nucleoside mannosyl-queuosine

Autori: Markus Hillmeier, Mirko Wagner, Timm Ensfelder, Eva Korytiakova, Peter Thumbs, Markus Müller, Thomas Carell
Pubblicato in: Nature Communications, Numero 12, 2021, Pagina/e 7123, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27371-9

5-Hydroxymethyl-, 5-Formyl- and 5-Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks

Autori: Florian Schelter, Angie Kirchner, Franziska R. Traube, Markus Müller, Wolfgang Steglich, Thomas Carell
Pubblicato in: Chemistry - A European Journal, Numero 27, 2021, Pagina/e 8100-8104, ISSN 1521-3765
Editore: Wiley-VCH
DOI: 10.1002/chem.202100551

Isoxazole Nucleosides as Building Blocks for a Plausible Proto-RNA

Autori: Felix Xu, Antony Crisp, Thea Schinkel, Romeo C.A. Dubini, Sarah Hübner, Sidney Becker, Florian Schelter, Petra Rovó, Thomas Carell
Pubblicato in: Angewandte Chemie International Edition, Numero 61(45), 2022, Pagina/e e202211945, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202211945

A Unifying Concept for the Prebiotic Formation of RNA Pyrimidine Nucleosides

Autori: Jonas Feldmann, Mads K. Skaanning, Marcus Lommel, Tobias Kernmayr, Peter Mayer, Thomas Carell
Pubblicato in: ChemistryEurope, Numero 1(1), 2023, Pagina/e e202300013, ISSN 2751-4765
Editore: Wiley-VCH
DOI: 10.1002/ceur.202300013

Suppression of SARS-CoV-2 Replication with Stabilized and Click-Chemistry Modified siRNAs

Autori: Franziska R. Traube, Marcel Stern, Annika J. Tölke, Martina Rudelius, Ernesto Mejías-Pérez, Nada Raddaoui, Beate M. Kümmerer, Céline Douat, Filipp Streshnev, Manuel Albanese, Paul R. Wratil, Yasmin V. Gärtner, Milda Nainyte, Grazia Giorgio, Stylianos Michalakis, Sabine Schneider, Hendrik Streeck, Markus Müller, Oliver T. Keppler, Thomas Carell
Pubblicato in: Angewandte Chemie International Edition, Numero 61(38), 2022, Pagina/e e202204556, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202204556

Intragenomic decarboxylation of 5-carboxy-2’-deoxycytidine

Autori: Ewelina Kaminska; Eva Korytiaková; Andreas Reichl; Markus Müller; Thomas Carell
Pubblicato in: Angewandte Chemie (International Ed. in English), Numero 60, 2021, Pagina/e 23207-23211, ISSN 1521-3773
Editore: Wiley-VCH
DOI: 10.1002/anie.202109995

Loading of Amino Acids onto RNA in a Putative RNA-Peptide World

Autori: Johannes N. Singer, Felix M. Müller, Ewa Węgrzyn, Christina Hölzl, Hans Hurmiz, Chuyi Liu, Luis Escobar, Thomas Carell
Pubblicato in: Angewandte Chemie International Edition, Numero 62(21), 2023, Pagina/e e202302360, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202302360

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Autori: Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis, Thomas Carell
Pubblicato in: Nature Communications, Numero 12, 2021, Pagina/e 4100, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24353-9

Comparative nucleosomal reactivity of 5-formyl-uridine and 5-formyl-cytidine

Autori: Leander Simon Runtsch; Michael Stadlmeier; Alexander Schön; Markus Müller; Thomas Carell
Pubblicato in: Chemistry (Weinheim an Der Bergstrasse, Germany), Numero 27, 2021, Pagina/e 12747-12752, ISSN 1521-3765
Editore: Wiley-VCH
DOI: 10.1002/chem.202102159

Impact of 5-formylcytosine on the melting kinetics of DNA by 1H NMR chemical exchange

Autori: Romeo C A Dubini, Alexander Schön, Markus Müller, Thomas Carell, and Petra Rovó
Pubblicato in: Nucleic Acids Research, Numero 48, 2020, Pagina/e 8796-8807, ISSN 1362-4962
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa589

Third-Generation Sequencing of Epigenetic DNA

Autori: Bethany Searle, Markus Müller, Thomas Carell, Andrew Kellett
Pubblicato in: Angewandte Chemie International Edition, Numero 62(14), 2023, Pagina/e e202215704, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202215704

Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis

Autori: Sidney Becker, Christina Schneider, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Milan Dejmek, Thomas Carell
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-02639-1

Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth-Generation by Prebiotic Methylations and Carbamoylations

Autori: Christina Schneider, Sidney Becker, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Michael Stadlmeier, Thomas Carell
Pubblicato in: Angewandte Chemie International Edition, Numero 57/20, 2018, Pagina/e 5943-5946, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201801919

Non-canonical nucleosides and chemistry of the emergence of life

Autori: Sidney Becker, Christina Schneider, Antony Crisp, Thomas Carell
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-07222-w

5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo

Autori: Katharina Iwan, René Rahimoff, Angie Kirchner, Fabio Spada, Arne S Schröder, Olesea Kosmatchev, Shqiponja Ferizaj, Jessica Steinbacher, Edris Parsa, Markus Müller, Thomas Carell
Pubblicato in: Nature Chemical Biology, Numero 14/1, 2018, Pagina/e 72-78, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/nchembio.2531

A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions

Autori: Hidenori Okamura, Sidney Becker, Niklas Tiede, Stefan Wiedemann, Jonas Feldmann, Thomas Carell
Pubblicato in: Chemical Communications, Numero 55/13, 2019, Pagina/e 1939-1942, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c8cc09435g

Super-sensitive multi-fluorophore RNA-FISH for early virus detection and flow-FISH using click chemistry

Autori: Nada Raddaoui, Stefano Groce, Florian Geiger, Alexander Borodavka, Leonhard Möckl, Samuele Stazzoni, Bastien Viverge, Christoph Bräuchle, Thomas Frischmuth, Hanna Engelke, Thomas Carell
Pubblicato in: ChemBioChem, Numero 18.03.2020, 2020, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000081

Synthesis and Incorporation of k 2 U into RNA

Autori: Milda Nainyte, Thomas Carell
Pubblicato in: Helvetica Chimica Acta, Numero 103/3, 2020, ISSN 0018-019X
Editore: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.202000016

TLR8 Is a Sensor of RNase T2 Degradation Products

Autori: Wilhelm Greulich, Mirko Wagner, Moritz M. Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung
Pubblicato in: Cell, Numero 179/6, 2019, Pagina/e 1264-1275.e13, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2019.11.001

A Click‐Chemistry Linked 2′3′‐cGAMP Analogue

Autori: Clemens Reto Dialer, Samuele Stazzoni, David Jan Drexler, Felix Moritz Müller, Simon Veth, Alexander Pichler, Hidenori Okamura, Gregor Witte, Karl‐Peter Hopfner, Thomas Carell
Pubblicato in: Chemistry – A European Journal, Numero 25/8, 2019, Pagina/e 2089-2095, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201805409

Proto‐Urea‐RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides

Autori: Hidenori Okamura, Antony Crisp, Sarah Hübner, Sidney Becker, Petra Rovó, Thomas Carell
Pubblicato in: Angewandte Chemie International Edition, Numero 58/51, 2019, Pagina/e 18691-18696, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201911746

A Click‐Chemistry‐Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry

Autori: Michael Stadlmeier, Leander Simon Runtsch, Filipp Streshnev, Martin Wühr, Thomas Carell
Pubblicato in: ChemBioChem, Numero 21/1-2, 2019, Pagina/e 103-107, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900611

Influencing Epigenetic Information with a Hydrolytically Stable Carbocyclic 5‐Aza‐2′‐deoxycytidine

Autori: Thomas M. Wildenhof, Sarah Schiffers, Franziska R. Traube, Peter Mayer, Thomas Carell
Pubblicato in: Angewandte Chemie International Edition, Numero 58/37, 2019, Pagina/e 12984-12987, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201904794

ALKBH5-induced demethylation of mono- and dimethylated adenosine

Autori: Timm T. Ensfelder, Matthias Q. Kurz, Katharina Iwan, Simon Geiger, Sarah Matheisl, Markus Müller, Roland Beckmann, Thomas Carell
Pubblicato in: Chemical Communications, Numero 54/62, 2018, Pagina/e 8591-8593, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c8cc03980a

Synthesis of an acp 3 U phosphoramidite and incorporation of the hypermodified base into RNA

Autori: Milda Nainytė, Tynchtyk Amatov, Thomas Carell
Pubblicato in: Chemical Communications, Numero 55/81, 2019, Pagina/e 12216-12218, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c9cc06314e

Synthesis of galactosyl‐queuosine and distribution of hypermodified Q‐nucleosides in mouse tissues

Autori: Peter Thumbs, Timm T. Ensfelder, Markus Hillmeier, Mirko Wagner, Matthias Heiss, Constanze Scheel, Alexander Schön, Markus Müller, Stylianos Michalakis, Stefanie Kellner, Thomas Carell
Pubblicato in: Angewandte Chemie International Edition, Numero 11.03.2020, 2020, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202002295

Analysis of an Active Deformylation Mechanism of 5‐Formyl‐deoxycytidine (fdC) in Stem Cells

Autori: Alexander Schön, Ewelina Kaminska, Florian Schelter, Eveliina Ponkkonen, Eva Korytiaková, Sarah Schiffers, Thomas Carell
Pubblicato in: Angewandte Chemie International Edition, Numero 59/14, 2020, Pagina/e 5591-5594, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202000414

Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides

Autori: Sidney Becker, Jonas Feldmann, Stefan Wiedemann, Hidenori Okamura, Christina Schneider, Katharina Iwan, Antony Crisp, Martin Rossa, Tynchtyk Amatov, Thomas Carell
Pubblicato in: Science, Numero 366/6461, 2019, Pagina/e 76-82, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aax2747

Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists

Autori: Samuele Stazzoni, Daniel F.R. Böhmer, Fabian Hernichel, Dilara Özdemir, Aikaterini Pappa, David Drexler, Stefan Bauernfeind, Gregor Witte, Mirko Wagner, Simon Veth, Karl-Peter Hopfner, Veit Hornung, Lars M. König, Thomas Carell
Pubblicato in: Angewandte Chemie International Edition, Numero 61(40), 2022, Pagina/e e202207175, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202207175

Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency.

Autori: Bianca B. Jütte; Calvin Krollmann; Kevin Cieslak; Ruth-Miriam Koerber; Peter Boor; Claus Moritz Graef; Eva Bartok; Eva Bartok; Mirko Wagner; Thomas Carell; Jennifer Landsberg; Pia Aymans; Jörg Wenzel; Peter Brossart; Lino L. Teichmann
Pubblicato in: iScience, Numero 24(8), 2021, Pagina/e 102833, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2021.102833

An Aminoisoxazole-Based Proto-RNA

Autori: Felix Xu, Stefan Wiedemann, Jonas Feldmann, Sidney Becker, Thomas Carell
Pubblicato in: ChemistryEurope, Numero 1(3), 2023, Pagina/e e202300057, ISSN 2751-4765
Editore: Wiley-VCH
DOI: 10.1002/ceur.202300057

DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

Autori: J. B. Alberge, F. Magrangeas, M. Wagner, S. Denié, C. Guérin-Charbonnel, L. Campion, M. Attal, H. Avet-Loiseau, T. Carell, P. Moreau, S. Minvielle, A. A. Sérandour
Pubblicato in: Clinical Epigenetics, Numero 12(1), 2020, Pagina/e 163, ISSN 1868-7083
Editore: Springer Nature
DOI: 10.1186/s13148-020-00953-y

Deformylation of 5-Formylcytidine in Different Cell Types.

Autori: Eva Korytiaková; Ewelina Kaminska; Markus Müller; Thomas Carell
Pubblicato in: Angewandte Chemie (International Ed. in English), Numero 60, 2021, Pagina/e 16869-16873, ISSN 1521-3773
Editore: Wiley-VCH
DOI: 10.1002/anie.202107089

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