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Developing Smart 3D Scaffolds based on Conductive Polymers and Carbon Nanotubes for Cardiac Tissue Engineering

Objective

Conductive polymers (CP) appear as promising stimulus-responsing electroactive biomaterial for profileration of cells. CP are versatile materials that can be synthesized in different shapes and morphologies, offering a wide range of application in biosensing, implants, drug delivery and tissue engineering. Carbon Nanotubes (CNTs) have become promising advanced materials and gained increasing importance for applications in nanomedicine, such as diagnosis, disease treatment, imaging, and tissue engineering. CNTs can interact with cells, cross the biological barriers, and modify their functions and biology. More recently, CNTs have become a new tool to specifically interact with the central nervous systems and support tissue repair after brain damage. Take into account of such findings, we hypothesize that CNTs exert functional effects on networks of cardiac myocytes and, in addition, the combination of those two materials will generate an outstanding scaffold for other electroactive cell growth, such as cardiac cells. In my current research, I have developed 3D scaffolds of CNT with a CP skeleton (polypyrrole or PEDOT) and aftewards, the goal of my research and thus the aim of the current proposal is to test such scaffolds for cardiac tissue regeneration. More specific aims are:
1) Adapt already developed smart “scaffold-matrix supports” for heart tissue engineering and test its viability, comprising CNT and conductive polymers.
2) In vitro and in vivo studies of healthy and genetically modified cardiomyocites (CM) of neonatal and adult rat hearts to determine the interactions between cells and the smart scaffolds and demonstrate that such devices promote heart cell growth and change their electrical properties.
3) Test other carbon nanomaterial scaffolds generated in the host group as supports for cardiac tissue engineering.

Field of science

  • /medical and health sciences/medical biotechnology/tissue engineering
  • /natural sciences/chemical sciences/polymer science
  • /medical and health sciences/medical biotechnology/nanomedicine
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants
  • /engineering and technology/environmental biotechnology/biosensing

Call for proposal

H2020-MSCA-IF-2016
See other projects for this call

Funding Scheme

MSCA-IF-GF - Global Fellowships

Coordinator

UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Address
Barrio Sarriena S N
48940 Leioa
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 257 191,20

Partners (1)

REGENTS OF THE UNIVERSITY OF COLORADO
United States
Address
Marine Street - Room 479 3100
80309-0572 Boulder Co
Activity type
Higher or Secondary Education Establishments