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Impact of air pollutants on cutaneous responses in both healthy and compromised skin barrier, and innovative solutions to protect skin against urban pollution

Objective

Nowadays, our skin is increasingly more assaulted, as a result of the increasingly complexity of our living environment. Because of its critical location, the skin is continuously exposed not only to natural environmental stress factors, such as UV radiation, ozone and extreme weather conditions associated with climatic changes, but also to pollutants/aggressors of anthropic origin, such as cigarette smoke and diesel/gasoline fuel exhaust. By combining the complementary expertise of the three partners involved in the present consortium, i.e. polymer technology and formulation expertise (DCE), skin barrier understanding and biochemistry/molecular biology (UoF), and impact of diesel/gasoline exhaust on cellular responses (UNIFR), this project will aim (i) at better understanding the consequences of air pollutants on both skin integrity and function, (ii) at investigating the synergistic effects of air pollutants such as ozone, cigarette smoke and diesel exhaust with UV radiation, (iii) at discovering innovative solutions to protect skin against those environmental stressors using both a curative approach based on the optimization of the delivery and efficacy of antioxidant compounds, and a preventive approach, based on the formation of a polymeric barrier film at the skin surface, (iv) at studying the impact of air pollutants on both healthy skin and compromised, damaged skin since the number of individuals suffering from skin diseases such as atopic dermatitis and psoriasis continuously increases with the increasingly level of air pollution and air-conditioning systems. The variety of training offered under this EID proposal will enable three early-stage researchers to build strong S&T background as well as to develop numerous transferable skills for their future career. The present training program will allow the researchers to expand their knowledge to new domains and applications, while also providing good networking opportunities.

Field of science

  • /humanities/arts/modern and contemporary art/film
  • /natural sciences/earth and related environmental sciences/environmental sciences/pollution

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Funding Scheme

MSCA-ITN-EID - European Industrial Doctorates

Coordinator

DOW SILICONES BELGIUM
Address
Rue Jules Bordet Parc Industriel Zone C
7180 Seneffe
Belgium
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 250 560

Participants (2)

UNIVERSITA DEGLI STUDI DI FERRARA
Italy
EU contribution
€ 258 061,32
Address
Via Ariosto 35
44121 Ferrara
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE FRIBOURG
Switzerland
EU contribution
€ 265 226,76
Address
Avenue De L Europe 20
1700 Fribourg
Activity type
Higher or Secondary Education Establishments

Partners (1)

BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
United States
Address
Serra Mall 450
94305 2004 Stanford
Activity type
Higher or Secondary Education Establishments