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Preclinical concept validation of tumor endothelial cell metabolism for novel anti-angiogenic therapy

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Publications

EndoDB: a database of endothelial cell transcriptomics data

Author(s): Shawez Khan, Federico Taverna, Katerina Rohlenova, Lucas Treps, Vincent Geldhof, Laura de Rooij, Liliana Sokol, Andreas Pircher, Lena-Christin Conradi, Joanna Kalucka, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Tobias Karakach, Xuri Li, Jermaine Goveia, Peter Carmeliet
Published in: Nucleic Acids Research, Issue 47/D1, 2018, Page(s) D736-D744, ISSN 0305-1048
DOI: 10.1093/nar/gky997

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism

Author(s): Nihed Draoui, Pauline de Zeeuw, Peter Carmeliet
Published in: Open Biology, Issue 7/12, 2017, Page(s) 170219, ISSN 2046-2441
DOI: 10.1098/rsob.170219

Endothelial Cell Metabolism

Author(s): Guy Eelen, Pauline de Zeeuw, Lucas Treps, Ulrike Harjes, Brian W. Wong, Peter Carmeliet
Published in: Physiological Reviews, Issue 98/1, 2018, Page(s) 3-58, ISSN 0031-9333
DOI: 10.1152/physrev.00001.2017

COVID-19: the vasculature unleashed

Author(s): Laure-Anne Teuwen, Vincent Geldhof, Alessandra Pasut, Peter Carmeliet
Published in: Nature Reviews Immunology, 2020, ISSN 1474-1733
DOI: 10.1038/s41577-020-0343-0

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

Author(s): Joanna Kalucka, Laura Bierhansl, Nadine Vasconcelos Conchinha, Rindert Missiaen, Ilaria Elia, Ulrike Brüning, Samantha Scheinok, Lucas Treps, Anna Rita Cantelmo, Charlotte Dubois, Pauline de Zeeuw, Jermaine Goveia, Annalisa Zecchin, Federico Taverna, Francisco Morales-Rodriguez, Aleksandra Brajic, Lena-Christin Conradi, Sandra Schoors, Ulrike Harjes, Kim Vriens, Gregor-Alexander Pilz, Rongyuan Ch
Published in: Cell Metabolism, Issue 28/6, 2018, Page(s) 881-894.e13, ISSN 1550-4131
DOI: 10.1016/j.cmet.2018.07.016

Blockade of myeloid-derived suppressor cell expansion with all-trans retinoic acid increases the efficacy of anti-angiogenic therapy

Author(s): Raimund Bauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ines Miranda Santos, Federico Taverna, Meike Kuhlencord, Victoria Gensch, Sarina Päsler, Stefan Vinckier, Johanna M Brandner, Klaus Pantel, Carsten Bokemeyer, Thomas Vogl, Johannes Roth, Peter Carmeliet, Sonja Loges
Published in: Cancer Research, 2018, Page(s) canres.3415.2017, ISSN 0008-5472
DOI: 10.1158/0008-5472.can-17-3415

RAISEing VEGF-D’s importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients

Author(s): P. Carmeliet, X. Li, L. Treps, L.-C. Conradi, S. Loges
Published in: Annals of Oncology, Issue 29/3, 2018, Page(s) 529-532, ISSN 0923-7534
DOI: 10.1093/annonc/mdy028

How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development

Author(s): Laure-Anne Teuwen, Vincent Geldhof, Peter Carmeliet
Published in: Developmental Biology, Issue 447/1, 2019, Page(s) 90-102, ISSN 0012-1606
DOI: 10.1016/J.YDBIO.2017.12.001

Hallmarks of Endothelial Cell Metabolism in Health and Disease

Author(s): Xuri Li, Xiaodong Sun, Peter Carmeliet
Published in: Cell Metabolism, Issue 30/3, 2019, Page(s) 414-433, ISSN 1550-4131
DOI: 10.1016/j.cmet.2019.08.011

The metabolic engine of endothelial cells

Author(s): Kim D. Falkenberg, Katerina Rohlenova, Yonglun Luo, Peter Carmeliet
Published in: Nature Metabolism, Issue 1/10, 2019, Page(s) 937-946, ISSN 2522-5812
DOI: 10.1038/s42255-019-0117-9

Metabolic Pathways Fueling the Endothelial Cell Drive

Author(s): Xuri Li, Anil Kumar, Peter Carmeliet
Published in: Annual Review of Physiology, Issue 81/1, 2019, Page(s) 483-503, ISSN 0066-4278
DOI: 10.1146/annurev-physiol-020518-114731

The role of endothelial cells in cystic fibrosis

Author(s): M. Declercq, L. Treps, P. Carmeliet, P. Witters
Published in: Journal of Cystic Fibrosis, Issue 18/6, 2019, Page(s) 752-761, ISSN 1569-1993
DOI: 10.1016/j.jcf.2019.07.005

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Author(s): Joanna Kalucka, Laura P.M.H. de Rooij, Jermaine Goveia, Katerina Rohlenova, Sébastien J. Dumas, Elda Meta, Nadine V. Conchinha, Federico Taverna, Laure-Anne Teuwen, Koen Veys, Melissa García-Caballero, Shawez Khan, Vincent Geldhof, Liliana Sokol, Rongyuan Chen, Lucas Treps, Mila Borri, Pauline de Zeeuw, Charlotte Dubois, Tobias K. Karakach, Kim D. Falkenberg, Magdalena Parys, Xiangke Yin, Stefan
Published in: Cell, Issue 180/4, 2020, Page(s) 764-779.e20, ISSN 0092-8674
DOI: 10.1016/j.cell.2020.01.015

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Author(s): Jermaine Goveia, Katerina Rohlenova, Federico Taverna, Lucas Treps, Lena-Christin Conradi, Andreas Pircher, Vincent Geldhof, Laura P.M.H. de Rooij, Joanna Kalucka, Liliana Sokol, Melissa García-Caballero, Yingfeng Zheng, Junbin Qian, Laure-Anne Teuwen, Shawez Khan, Bram Boeckx, Els Wauters, Herbert Decaluwé, Paul De Leyn, Johan Vansteenkiste, Birgit Weynand, Xavier Sagaert, Erik Verbeken, Albert
Published in: Cancer Cell, Issue 37/1, 2020, Page(s) 21-36.e13, ISSN 1535-6108
DOI: 10.1016/j.ccell.2019.12.001

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

Author(s): Katerina Rohlenova, Jermaine Goveia, Melissa García-Caballero, Abhishek Subramanian, Joanna Kalucka, Lucas Treps, Kim D. Falkenberg, Laura P.M.H. de Rooij, Yingfeng Zheng, Lin Lin, Liliana Sokol, Laure-Anne Teuwen, Vincent Geldhof, Federico Taverna, Andreas Pircher, Lena-Christin Conradi, Shawez Khan, Steve Stegen, Dena Panovska, Frederik De Smet, Frank J.T. Staal, Rene J. Mclaughlin, Stefan Vinc
Published in: Cell Metabolism, Issue 31/4, 2020, Page(s) 862-877.e14, ISSN 1550-4131
DOI: 10.1016/j.cmet.2020.03.009

BIOMEX: an interactive workflow for (single cell) omics data interpretation and visualization

Author(s): Federico Taverna, Jermaine Goveia, Tobias K Karakach, Shawez Khan, Katerina Rohlenova, Lucas Treps, Abhishek Subramanian, Luc Schoonjans, Mieke Dewerchin, Guy Eelen, Peter Carmeliet
Published in: Nucleic Acids Research, Issue 48/W1, 2020, Page(s) W385-W394, ISSN 0305-1048
DOI: 10.1093/nar/gkaa332

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation

Author(s): Sébastien J. Dumas, Elda Meta, Mila Borri, Jermaine Goveia, Katerina Rohlenova, Nadine V. Conchinha, Kim Falkenberg, Laure-Anne Teuwen, Laura de Rooij, Joanna Kalucka, Rongyuan Chen, Shawez Khan, Federico Taverna, Weisi Lu, Magdalena Parys, Carla De Legher, Stefan Vinckier, Tobias K. Karakach, Luc Schoonjans, Lin Lin, Lars Bolund, Mieke Dewerchin, Guy Eelen, Ton J. Rabelink, Xuri Li, Yonglun Luo,
Published in: Journal of the American Society of Nephrology, Issue 31/1, 2019, Page(s) 118-138, ISSN 1046-6673
DOI: 10.1681/asn.2019080832

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

Author(s): Guy Eelen, Charlotte Dubois, Anna Rita Cantelmo, Jermaine Goveia, Ulrike Brüning, Michael DeRan, Gopala Jarugumilli, Jos van Rijssel, Giorgio Saladino, Federico Comitani, Annalisa Zecchin, Susana Rocha, Rongyuan Chen, Hongling Huang, Saar Vandekeere, Joanna Kalucka, Christian Lange, Francisco Morales-Rodriguez, Bert Cruys, Lucas Treps, Leanne Ramer, Stefan Vinckier, Katleen Brepoels, Sabine Wyns,
Published in: Nature, Issue 561/7721, 2018, Page(s) 63-69, ISSN 0028-0836
DOI: 10.1038/s41586-018-0466-7

Endothelial cell metabolism

Author(s): Laure-Anne Teuwen, Nihed Draoui, Charlotte Dubois, Peter Carmeliet
Published in: Current Opinion in Hematology, Issue 24/3, 2017, Page(s) 240-247, ISSN 1065-6251
DOI: 10.1097/moh.0000000000000335

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

Author(s): Saar Vandekeere, Charlotte Dubois, Joanna Kalucka, Mark R. Sullivan, Melissa García-Caballero, Jermaine Goveia, Rongyuan Chen, Frances F. Diehl, Libat Bar-Lev, Joris Souffreau, Andreas Pircher, Saran Kumar, Stefan Vinckier, Yoshio Hirabayashi, Shigeki Furuya, Luc Schoonjans, Guy Eelen, Bart Ghesquière, Eli Keshet, Xuri Li, Matthew G. Vander Heiden, Mieke Dewerchin, Peter Carmeliet
Published in: Cell Metabolism, Issue 28/4, 2018, Page(s) 573-587.e13, ISSN 1550-4131
DOI: 10.1016/j.cmet.2018.06.009

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

Author(s): Ulrike Bruning, Francisco Morales-Rodriguez, Joanna Kalucka, Jermaine Goveia, Federico Taverna, Karla C.S. Queiroz, Charlotte Dubois, Anna Rita Cantelmo, Rongyuan Chen, Stefan Loroch, Evy Timmerman, Vanessa Caixeta, Katarzyna Bloch, Lena-Christin Conradi, Lucas Treps, An Staes, Kris Gevaert, Andrew Tee, Mieke Dewerchin, Clay F. Semenkovich, Francis Impens, Birgit Schilling, Eric Verdin, Johannes V
Published in: Cell Metabolism, Issue 28/6, 2018, Page(s) 866-880.e15, ISSN 1550-4131
DOI: 10.1016/j.cmet.2018.07.019

Analysis of Endothelial Fatty Acid Metabolism Using Tracer Metabolomics

Author(s): Joanna Kalucka, Bart Ghesquière, Sarah-Maria Fendt, Peter Carmeliet
Published in: High-Throughput Metabolomics - Methods and Protocols, Issue 1978, 2019, Page(s) 259-268
DOI: 10.1007/978-1-4939-9236-2_16