Preclinical concept validation of tumor endothelial cell metabolism for novel anti-angiogenic therapy

Publications

Cardiac Microvascular Endothelial Cells in Pressure Overload-Induced Heart Disease.

Author(s): S. Trenson, H. Hermans, S. Craps, P. Pokreisz, P. de Zeeuw, J. Van Wauwe, H. Gillijns, D. Veltman, F. Wei, E. Caluwe, R. Gijsbers, P. Baatsen, J.A. Staessen, B. Ghesquiere, P. CARMELIET, F. Rega, B. Meuris, B. Meyns, W. Oosterlinck, J. Duchenne, K. Goetschalckx, J.U. Voigt, M.C. Herregods, P. Herijgers, A. Luttun, and S. Janssens.
Published in: CIRCULATION-HEART FAILURE, Issue Volume 14 Issue 1, 2021, Page(s) 97-111, ISSN 1941-3297
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circheartfailure.120.006979

Hallmarks of Endothelial Cell Metabolism in Health and Disease.

Author(s): Li, Xuri; Sun, Xiaodong; Carmeliet, Peter
Published in: Cell Metabolism, Issue 5, 2019, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.08.011

Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells.

Author(s): A. Cuypers, L. A. Teuwen, V. L. Bridgeman, Lpmh de Rooij, G. Eelen, M. Dewerchin, A. R. Cantelmo, J. Kalucka, A. Bouche, S. Vinckier, A. Carton, A. Manderveld, P. B. Vermeulen, A. R. Reynolds & P. CARMELIET.
Published in: Star Protocols, 2022, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2022.101691

Metabolic Reprogramming in Tumor Endothelial Cells

Author(s): M. Garcia-Caballero, L. Sokol, A. Cuypers & P. CARMELIET
Published in: International Journal of Molecular Sciences, Issue Vol23/Issue19, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911052

Protocols for endothelial cell isolation from mouse tissues: brain, choroid, lung, and muscle

Author(s): N.V. Conchinha, L. Sokol, L.A. Teuwen, K. Veys, S.J. Dumas, E. Meta, M. Garcia-Caballero, V. Geldhof, R. Chen, L. Treps, M. Borri, P. de Zeeuw, K.D. Falkenberg, C. Dubois, M. Parys, L. de Rooij, K. Rohlenova, J. Goveia, L. Schoonjans, M. Dewerchin, G. Eelen, X. Li, J. Kalucka & P. CARMELIET.
Published in: Star Protocols, Issue Vollume 2 Issue 3, 2021, Page(s) 100508, ISSN 2666-1667
Publisher: Elsevier
DOI: 10.1016/j.xpro.2021.100508

Protocols for endothelial cell isolation from mouse tissues: small intestine, colon, heart, and liver

Author(s): L. Sokol, V. Geldhof, M. Garcia-Caballero, N.V. Conchinha, S.J. Dumas, E. Meta, L.A. Teuwen, K. Veys, R. Chen, L. Treps, M. Borri, P. de Zeeuw, K.D. Falkenberg, C. Dubois, M. Parys, L. de Rooij, J. Goveia, K. Rohlenova, L. Schoonjans, M. Dewerchin, G. Eelen, X. Li, J. Kalucka, & P. CARMELIET.
Published in: Star Protocols, Issue Volume 2 Issue 2, 2021, Page(s) 100489, ISSN 2666-1667
Publisher: Elsevier
DOI: 10.1016/j.xpro.2021.100489

Tumor vessel co-option probed by single-cell analysis.

Author(s): L.A. Teuwen, L. De Rooij, A. Cuypers, K. Rohlenova, S.J. Dumas, M. Garcia-Caballero, E. Meta, J. Amersfoort, F. Taverna, L.M. Becker, N. Veiga, A.R. Cantelmo, V. Geldhof, N.V. Conchinha, J. Kalucka, L. Treps, L.C. Conradi, S. Khan, T.K. Karakach, S. Soenen, S. Vinckier, L. Schoonjans, G. Eelen, S. Van Laere, M. Dewerchin, L. Dirix, M. Mazzone, Y. Luo, P. Vermeulen & P. CARMELIET
Published in: Cell Reports, Issue Volume 35 Issue 11, 2021, Page(s) ARTN 109253, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109253

Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity

Author(s): K. Veys, Z. Fan, M. Ghobrial, A. Bouche, M. Garcia-Caballero, K. Vriens, N. V. Conchinha, A. Seuwen, F. Schlegel, T. Gorski, M. Crabbe, P. Gilardoni, R. Ardicoglu, J. Schaffenrath, C. Casteels, G. De Smet, I. Smolders, K. Van Laere, E. D. Abel, S. M. Fendt, A. Schroeter, J. Kalucka, A. R. Cantelmo, T. Walchli, A. Keller, P. CARMELIET & K. De Bock
Published in: Circulation Research, 2020, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.316463

Endothelial metabolism going single

Author(s): A. Subramanian, L. M. Becker & P. CARMELIET
Published in: NATURE METABOLISM, Issue Volume 3 Issue 5, 2021, Page(s) 593-594, ISSN 2522-5812
Publisher: NATURE RESEARCH
DOI: 10.1038/s42255-021-00399-3

Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis

Author(s): R. Tillie, J. De Bruijn, J. Perales-Paton, L. Temmerman, Y. Ghosheh, K. Van Kuijk, M.J. Gijbels, P. CARMELIET, K. Ley, J. Saez-Rodriguez & J.C. Sluimer
Published in: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, Issue Volume 9, 2021, Page(s) 11 pages ARTN 695684, ISSN 2296-634X
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.695684

Endothelial CFTR dysfunction and its involvement in the pathogenesis of pulmonary arterial hypertension

Author(s): M. Declercq, L. Treps, S. Bousfia, P. CARMELIET & P. Witters
Published in: EUROPEAN RESPIRATORY JOURNAL, Issue Volume 58 Issue 2, 2021, Page(s) ARTN 2101645, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.01645-2021

Angiogenesis goes computational – The future way forward to discover new angiogenic targets?

Author(s): A. Subramanian, P. Zakeri, M. Mousa, H. Alnaqbi, F. Y. Alshamsi, L. Bettoni, E. Damiani, H. Alsafar, Y. Saeys & P. CARMELIET
Published in: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, Issue Vol 20, 2022, Page(s) 5235-5255, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2022.09.019

Vasculogenesis in kidney organoids upon transplantation

Author(s): M.S. Koning, S. J. Dumas, M. C. Avramut, R. I. Koning, E. Meta, et al, P. Carmeliet, et al
Published in: NPJ Regen Med, 2022, ISSN 2057-3995
Publisher: Nature Portfolio
DOI: 10.1038/s41536-022-00237-4

Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancer

Author(s): an Nyen, T., M. Planque, L. van Wagensveld, J. A. G. Duarte, E. A. Zaal, A. Talebi, M. Rossi, P. R. Korner, et al, P. Carmeliet, et al
Published in: Nature Communications, Issue Vol 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32272-6

Macrophage-derived glutamine boosts satellite cells and muscle regeneration.

Author(s): M. Shang, F. Cappellesso, R. Amorim, J. Serneels, F. Virga, G. Eelen, S. Carobbio, M. Y. Rincon, P. Maechler, K. De Bock, P. C. Ho, M. Sandri, B. Ghesquiere, P. CARMELIET, M. Di Matteo, E. Berardi & M. Mazzone. Macrophage-derived glutamine boosts satellite cells and muscle regeneration.
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2857-9

Glutamine Metabolism in Osteoprogenitors Is Required for Bone Mass Accrual and PTH-Induced Bone Anabolism in Male Mice

Author(s): S. Stegen, C. S. Devignes, S. Torrekens, R. Van Looveren, P. CARMELIET & G. Carmeliet.
Published in: JOURNAL OF BONE AND MINERAL RESEARCH, Issue Volume 36 Issue 3, 2021, Page(s) 604-616, ISSN 0884-0431
Publisher: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4219

Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice.

Author(s): J.A.F. Demandt, K. van Kuijk, T.L. Theelen, E. Marsch, S.P. Heffron, E.A. Fisher, P. CARMELIET, E.A.L. Biessen, and J.C. Sluimer.
Published in: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, Issue Volume 9, 2021, Page(s) 10 pages ARTN 664258, ISSN 2296-634X
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.664258

Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain

Author(s): T. Walchli, J. Bisschop, A. Miettinen, A. Ulmann-Schuler, C. Hintermuller, E.P. Meyer, T. Krucker, R. Walchli, P.P. Monnier
Published in: NATURE PROTOCOLS, Issue Volume 16 Issue 10, 2021, Page(s) 4564, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00587-1

c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Author(s): J. Leslie, M. G. Macia, S. Luli, J. C. Worrell, W. J. Reilly, H. L. Paish, A. Knox, B. S. Barksby, L. M. Gee, M. Y. W. Zaki, A. L. Collins, R. A. Burgoyne, R. Cameron, C. Bragg, X. Xu, G. W. Chung, C. D. A. Brown, A. D. Blanchard, C. B. Nanthakumar, M. Karsdal, S. M. Robinson, D. M. Manas, G. Sen, J. French, S. A. White, S. Murphy, M. Trost, J. L. Zakrzewski, U. Klein, R. F. Schwabe, I. Mederacke,
Published in: Nature Metabolism, 2020, ISSN 2522-5812
Publisher: Nature
DOI: 10.1038/s42255-020-00306-2

Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level

Author(s): F. Wang, P. Ding, X. Liang, et al, P. Carmeliet, et al
Published in: Nature communications, Issue Vol13,3620, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34498-w

CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation

Author(s): Fernandez-Garcia, J., F. Franco, S. Parik, P. Altea-Manzano, A. A. Pane, D. Broekaert, J. van Elsen, I. Vermeire, T. Schalley, M. Planque, T. van Brussel, R. Schepers, E. Modave, T. K. Karakach, P. CARMELIET, D. Lambrechts, P. C. Ho, and S. M. Fendt
Published in: Cell Reports, Issue Volume 41, Issue7, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111639

Gas6 is dispensable for pubertal mammary gland development.

Author(s): Mills, Kylie L.; Gomes, Angelica M.; Standlee, Courtney R.; Rojo, Michelle D.; Carmeliet, Peter; Lin, Zhen; Machado, Heather L.
Published in: PLoS ONE, Issue 1, 2018, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0208550

Protocols for endothelial cell isolation from mouse tissues: kidney, spleen, and testis.

Author(s): S.J. Dumas, E. Meta, N.V. Conchinha, L. Sokol, R. Chen, M. Borri, L.A. Teuwen, K. Veys, M. Garcia-Caballero, V. Geldhof, L. Treps, P. de Zeeuw, K.D. Falkenberg, C. Dubois, M. Parys, L. de Rooij, K. Rohlenova, J. Goveia, L. Schoonjans, M. Dewerchin, G. Eelen, X. Li, J. Kalucka & P. CARMELIET
Published in: Star Protocols, Issue Volume 2 Issue 3, 2021, Page(s) 100523, ISSN 2666-1667
Publisher: Elsevier
DOI: 10.1016/j.xpro.2021.100523

The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors

Author(s): A. De Zutter, H. Crijns, N. Berghmans, M. Garcia-Caballero, L. Vanbrabant, N. Portner, V. Vanheule, P. Verscheure, M.M. Siddiquei, A.M. Abu El-Asrar, P. CARMELIET, P. Van Wielendaele, I. De Meester, J. Van Damme, P. Proost & S. Struyf.
Published in: Cancers, Issue volume 13 Issue 20, 2021, Page(s) ARTN 5090, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13205090

De novo serine synthesis regulates chondrocyte proliferation during bone development and repair

Author(s): Stegen, S., S. Loopmans, I. Stockmans, K. Moermans, P. CARMELIET & G. Carmeliet
Published in: Bone Research, 2021, ISSN 2095-4700
Publisher: Sichuan University Press
DOI: 10.1038/s41413-021-00185-7

Metabolic signatures of distinct endothelial phenotypes

Author(s): S.J. Dumas, M. Garcia-Caballero & P. CARMELIET
Published in: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2020, ISSN 1043-2760
Publisher: Elsevier BV
DOI: 10.1016/j.tem.2020.05.009

Endothelial cell metabolism:: an update anno 2017

Author(s): LA Teuwen, N Draoui, C Dubois, P Carmeliet
Published in: Current Opinion in Hematology, 2017, ISSN 1065-6251
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/moh.0000000000000335

Deciphering Endothelial Heterogeneity in Health and Disease at Single Cell Resolution: Progress and Perspectives.

Author(s): Becker, L. M., S. H. Chen, J. Rodor, Lpmh de Rooij, A. H. Baker, & P. CARMELIET.
Published in: CARDIOVASCULAR RESEARCH, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac018

Prominin-1 controls stem cell activation by orchestrating ciliary dynamics

Author(s): Singer, Donald; Thamm, Kristina; Zhuang, Heng; Karbanová, Jana; Gao, Yan; Walker, Jemma Victoria; Jin, Heng; Wu, Xiangnan; Coveney, Clarissa R; Marangoni, Pauline; Lu, Dongmei; Grayson, Portia Rebecca Clare; Gulsen, Tulay; Liu, Karen J; Ardu, Stefano; Wann, Angus KT; Luo, Shouqing; Zambon, Alexander C; Jetten, Anton M; Tredwin, Christopher; Klein, Ophir D; Attanasio, Massimo; Carmeliet, Peter; Hu
Published in: Embo Journal, Issue 1, 2019, ISSN 1460-2075
Publisher: Wiley
DOI: 10.15252/embj.201899845

A Role for the Vascular Endothelium in Post-Acute COVID-19?

Author(s): de Rooij, Lpmh, L. M. Becker & P. CARMELIET
Published in: CIRCULATION, Issue Volume 145 Issue 20, 2021, Page(s) 1503-1505, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.059231

EndoDB: a database of endothelial cell transcriptomics data

Author(s): Shawez Khan, Federico Taverna, Katerina Rohlenova, Lucas Treps, Vincent Geldhof, Laura de Rooij, Liliana Sokol, Andreas Pircher, Lena-Christin Conradi, Joanna Kalucka, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Tobias Karakach, Xuri Li, Jermaine Goveia, Peter Carmeliet
Published in: Nucleic Acids Research, Issue 47/D1, 2018, Page(s) D736-D744, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky997

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism

Author(s): Nihed Draoui, Pauline de Zeeuw, Peter Carmeliet
Published in: Open Biology, Issue 7/12, 2017, Page(s) 170219, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1098/rsob.170219

Endothelial Cell Metabolism

Author(s): Guy Eelen, Pauline de Zeeuw, Lucas Treps, Ulrike Harjes, Brian W. Wong, Peter Carmeliet
Published in: Physiological Reviews, Issue 98/1, 2018, Page(s) 3-58, ISSN 0031-9333
Publisher: American Physiological Society
DOI: 10.1152/physrev.00001.2017

COVID-19: the vasculature unleashed

Author(s): Laure-Anne Teuwen, Vincent Geldhof, Alessandra Pasut, Peter Carmeliet
Published in: Nature Reviews Immunology, 2020, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-020-0343-0

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

Author(s): Joanna Kalucka, Laura Bierhansl, Nadine Vasconcelos Conchinha, Rindert Missiaen, Ilaria Elia, Ulrike Brüning, Samantha Scheinok, Lucas Treps, Anna Rita Cantelmo, Charlotte Dubois, Pauline de Zeeuw, Jermaine Goveia, Annalisa Zecchin, Federico Taverna, Francisco Morales-Rodriguez, Aleksandra Brajic, Lena-Christin Conradi, Sandra Schoors, Ulrike Harjes, Kim Vriens, Gregor-Alexander Pilz, Rongyuan Ch
Published in: Cell Metabolism, Issue 28/6, 2018, Page(s) 881-894.e13, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.07.016

Blockade of myeloid-derived suppressor cell expansion with all-trans retinoic acid increases the efficacy of anti-angiogenic therapy

Author(s): Raimund Bauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ines Miranda Santos, Federico Taverna, Meike Kuhlencord, Victoria Gensch, Sarina Päsler, Stefan Vinckier, Johanna M Brandner, Klaus Pantel, Carsten Bokemeyer, Thomas Vogl, Johannes Roth, Peter Carmeliet, Sonja Loges
Published in: Cancer Research, 2018, Page(s) canres.3415.2017, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-17-3415

RAISEing VEGF-D’s importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients

Author(s): P. Carmeliet, X. Li, L. Treps, L.-C. Conradi, S. Loges
Published in: Annals of Oncology, Issue 29/3, 2018, Page(s) 529-532, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1093/annonc/mdy028

How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development

Author(s): Laure-Anne Teuwen, Vincent Geldhof, Peter Carmeliet
Published in: Developmental Biology, Issue 447/1, 2019, Page(s) 90-102, ISSN 0012-1606
Publisher: Academic Press
DOI: 10.1016/J.YDBIO.2017.12.001

The metabolic engine of endothelial cells

Author(s): Kim D. Falkenberg, Katerina Rohlenova, Yonglun Luo, Peter Carmeliet
Published in: Nature Metabolism, Issue 1/10, 2019, Page(s) 937-946, ISSN 2522-5812
Publisher: Springer Nature
DOI: 10.1038/s42255-019-0117-9

Metabolic Pathways Fueling the Endothelial Cell Drive

Author(s): Xuri Li, Anil Kumar, Peter Carmeliet
Published in: Annual Review of Physiology, Issue 81/1, 2019, Page(s) 483-503, ISSN 0066-4278
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-physiol-020518-114731

The role of endothelial cells in cystic fibrosis

Author(s): M. Declercq, L. Treps, P. Carmeliet, P. Witters
Published in: Journal of Cystic Fibrosis, Issue 18/6, 2019, Page(s) 752-761, ISSN 1569-1993
Publisher: Elsevier BV
DOI: 10.1016/j.jcf.2019.07.005

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Author(s): Joanna Kalucka, Laura P.M.H. de Rooij, Jermaine Goveia, Katerina Rohlenova, Sébastien J. Dumas, Elda Meta, Nadine V. Conchinha, Federico Taverna, Laure-Anne Teuwen, Koen Veys, Melissa García-Caballero, Shawez Khan, Vincent Geldhof, Liliana Sokol, Rongyuan Chen, Lucas Treps, Mila Borri, Pauline de Zeeuw, Charlotte Dubois, Tobias K. Karakach, Kim D. Falkenberg, Magdalena Parys, Xiangke Yin, Stefan
Published in: Cell, Issue 180/4, 2020, Page(s) 764-779.e20, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.01.015

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Author(s): Jermaine Goveia, Katerina Rohlenova, Federico Taverna, Lucas Treps, Lena-Christin Conradi, Andreas Pircher, Vincent Geldhof, Laura P.M.H. de Rooij, Joanna Kalucka, Liliana Sokol, Melissa García-Caballero, Yingfeng Zheng, Junbin Qian, Laure-Anne Teuwen, Shawez Khan, Bram Boeckx, Els Wauters, Herbert Decaluwé, Paul De Leyn, Johan Vansteenkiste, Birgit Weynand, Xavier Sagaert, Erik Verbeken, Albert
Published in: Cancer Cell, Issue 37/1, 2020, Page(s) 21-36.e13, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2019.12.001

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

Author(s): Katerina Rohlenova, Jermaine Goveia, Melissa García-Caballero, Abhishek Subramanian, Joanna Kalucka, Lucas Treps, Kim D. Falkenberg, Laura P.M.H. de Rooij, Yingfeng Zheng, Lin Lin, Liliana Sokol, Laure-Anne Teuwen, Vincent Geldhof, Federico Taverna, Andreas Pircher, Lena-Christin Conradi, Shawez Khan, Steve Stegen, Dena Panovska, Frederik De Smet, Frank J.T. Staal, Rene J. Mclaughlin, Stefan Vinc
Published in: Cell Metabolism, Issue 31/4, 2020, Page(s) 862-877.e14, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.03.009

BIOMEX: an interactive workflow for (single cell) omics data interpretation and visualization

Author(s): Federico Taverna, Jermaine Goveia, Tobias K Karakach, Shawez Khan, Katerina Rohlenova, Lucas Treps, Abhishek Subramanian, Luc Schoonjans, Mieke Dewerchin, Guy Eelen, Peter Carmeliet
Published in: Nucleic Acids Research, Issue 48/W1, 2020, Page(s) W385-W394, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa332

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

Author(s): Guy Eelen, Charlotte Dubois, Anna Rita Cantelmo, Jermaine Goveia, Ulrike Brüning, Michael DeRan, Gopala Jarugumilli, Jos van Rijssel, Giorgio Saladino, Federico Comitani, Annalisa Zecchin, Susana Rocha, Rongyuan Chen, Hongling Huang, Saar Vandekeere, Joanna Kalucka, Christian Lange, Francisco Morales-Rodriguez, Bert Cruys, Lucas Treps, Leanne Ramer, Stefan Vinckier, Katleen Brepoels, Sabine Wyns,
Published in: Nature, Issue 561/7721, 2018, Page(s) 63-69, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0466-7

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

Author(s): Saar Vandekeere, Charlotte Dubois, Joanna Kalucka, Mark R. Sullivan, Melissa García-Caballero, Jermaine Goveia, Rongyuan Chen, Frances F. Diehl, Libat Bar-Lev, Joris Souffreau, Andreas Pircher, Saran Kumar, Stefan Vinckier, Yoshio Hirabayashi, Shigeki Furuya, Luc Schoonjans, Guy Eelen, Bart Ghesquière, Eli Keshet, Xuri Li, Matthew G. Vander Heiden, Mieke Dewerchin, Peter Carmeliet
Published in: Cell Metabolism, Issue 28/4, 2018, Page(s) 573-587.e13, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.06.009

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

Author(s): Ulrike Bruning, Francisco Morales-Rodriguez, Joanna Kalucka, Jermaine Goveia, Federico Taverna, Karla C.S. Queiroz, Charlotte Dubois, Anna Rita Cantelmo, Rongyuan Chen, Stefan Loroch, Evy Timmerman, Vanessa Caixeta, Katarzyna Bloch, Lena-Christin Conradi, Lucas Treps, An Staes, Kris Gevaert, Andrew Tee, Mieke Dewerchin, Clay F. Semenkovich, Francis Impens, Birgit Schilling, Eric Verdin, Johannes V
Published in: Cell Metabolism, Issue 28/6, 2018, Page(s) 866-880.e15, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.07.019

Mitochondrial respiration supports autophagy to provide stress resistance during quiescence.

Author(s): Magalhaes-Novais, S., J. Blecha, R. Naraine, J. Mikesova, P. Abaffy, A. Pecinova, M. Milosevic, R. Bohuslavova, J. Prochazka, S. Khan, E. Novotna, R. Sindelka, R. Machan, M. Dewerchin, E. Vlcak, J. Kalucka, S. Stemberkova Hubackova, A. Benda, J. Goveia, T. Mracek, C. Barinka, P. CARMELIET, J. Neuzil, K. Rohlenova & J. Rohlena.
Published in: AUTOPHAGY, 2021, ISSN 1554-8627
Publisher: Landes Bioscience
DOI: 10.1080/15548627.2022.2038898

Tumor vessel co-option: The past & the future

Author(s): A. Cuypers, A. K. Truong, L. M. Becker, P. Saavedra-Garcia, & P. CARMELIET
Published in: Frontiers in Oncology, Issue Vol 12, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.965277

Basic and Therapeutic Aspects of Angiogenesis Updated

Author(s): Eelen, Guy; Treps, Lucas; Li, Xuri; Carmeliet, Peter
Published in: CIRCULATION RESEARCH, 2020, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316851

Endothelial cell plasticity at the single-cell level

Author(s): A. Pasut, Lisa M. Becker, A. Cuypers & P. CARMELIET
Published in: Angiogenesis, Issue volume 24 Issue 2, 2021, Page(s) 311-326, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-021-09797-3

The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single cell resolution

Author(s): Lpmh de Rooij, L. M. Becker, L. A. Teuwen, B. Boeckx, S. Jansen, S. Feys, S. Verleden, L. Liesenborghs, et al & P Carmeliet
Published in: Cardiovascular Research, Issue cva139, 2022, ISSN 1755-3245
Publisher: Oxford Univ Press
DOI: 10.1093/cvr/cvac139

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation

Author(s): Sébastien J. Dumas, Elda Meta, Mila Borri, Jermaine Goveia, Katerina Rohlenova, Nadine V. Conchinha, Kim Falkenberg, Laure-Anne Teuwen, Laura de Rooij, Joanna Kalucka, Rongyuan Chen, Shawez Khan, Federico Taverna, Weisi Lu, Magdalena Parys, Carla De Legher, Stefan Vinckier, Tobias K. Karakach, Luc Schoonjans, Lin Lin, Lars Bolund, Mieke Dewerchin, Guy Eelen, Ton J. Rabelink, Xuri Li, Yonglun Luo
Published in: Journal of the american society of nephrology, Issue 31 (1), 2020, Page(s) 118-138, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2019080832

Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype

Author(s): M. Declercq, P. de Zeeuw, N. Vasconcelos Conchinha, V. Geldhof, A. S. Ramalho, M. Garcia-Caballero, K. Brepoels, M. Ensinck, M. S. Carlon, M. J. Bird, S. Vinckier, M. Proesmans, F. Vermeulen, L. Dupont, B. Ghesquiere, M. Dewerchin, P. CARMELIET, D. Cassiman, L. Treps, G. Eelen & P. Witters
Published in: EUROPEAN RESPIRATORY JOURNAL, Issue Volume 57 Issue 4, 2021, Page(s) ARTN 2000261, ISSN 0903-1936
Publisher: European Respiratory Society
DOI: 10.1183/13993003.00261-2020

Phenotypic diversity and metabolic specialization of renal endothelial cells

Author(s): S.J. Dumas, E. Meta, M. Borri, Y. Luo, X. Li, T.J. Rabelink & .P. CARMELIET.
Published in: NATURE REVIEWS NEPHROLOGY, Issue volume 17 Issue 7, 2021, ISSN 1759-5061
Publisher: Nature Publishing Group
DOI: 10.1038/s41581-021-00411-9

Immunomodulation by endothelial cells – partnering up with the immune system?

Author(s): J. Amersfoort, G. Eelen & P. CARMELIET
Published in: NATURE REVIEWS IMMUNOLOGY, 2021, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-022-00694-4

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

Author(s): M.D. Mana, A.M. Hussey, C.N. Tzouanas, S. Imada, Y. Barrera Millan, D. Bahceci, D.R. Saiz, A.T. Webb, C.A. Lewis, P. CARMELIET, M.M. Mihaylova, A.K. Shalek, and O.H. Yilmaz
Published in: CELL REPORTS, Issue Volume 35 Issue 10, 2021, Page(s) ARTN 109212, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109212

Analysis of Endothelial Fatty Acid Metabolism Using Tracer Metabolomics.

Author(s): Joanna Kalucka; Bart Ghesquière; Sarah-Maria Fendt; Peter Carmeliet
Published in: Methods in Molecular Biology, Issue 2, 2019, ISBN 978-1-4939-9235-5
Publisher: HUMANA PRESS INC
DOI: 10.1007/978-1-4939-9236-2_16

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