Preclinical concept validation of tumor endothelial cell metabolism for novel anti-angiogenic therapy

Publicaciones

Cardiac Microvascular Endothelial Cells in Pressure Overload-Induced Heart Disease.

Autores: S. Trenson, H. Hermans, S. Craps, P. Pokreisz, P. de Zeeuw, J. Van Wauwe, H. Gillijns, D. Veltman, F. Wei, E. Caluwe, R. Gijsbers, P. Baatsen, J.A. Staessen, B. Ghesquiere, P. CARMELIET, F. Rega, B. Meuris, B. Meyns, W. Oosterlinck, J. Duchenne, K. Goetschalckx, J.U. Voigt, M.C. Herregods, P. Herijgers, A. Luttun, and S. Janssens.
Publicado en: CIRCULATION-HEART FAILURE, Edición Volume 14 Edición 1, 2021, Página(s) 97-111, ISSN 1941-3297
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circheartfailure.120.006979

Hallmarks of Endothelial Cell Metabolism in Health and Disease.

Autores: Li, Xuri; Sun, Xiaodong; Carmeliet, Peter
Publicado en: Cell Metabolism, Edición 5, 2019, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2019.08.011

Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells.

Autores: A. Cuypers, L. A. Teuwen, V. L. Bridgeman, Lpmh de Rooij, G. Eelen, M. Dewerchin, A. R. Cantelmo, J. Kalucka, A. Bouche, S. Vinckier, A. Carton, A. Manderveld, P. B. Vermeulen, A. R. Reynolds & P. CARMELIET.
Publicado en: Star Protocols, 2022, ISSN 2666-1667
Editor: Cell Press
DOI: 10.1016/j.xpro.2022.101691

Metabolic Reprogramming in Tumor Endothelial Cells

Autores: M. Garcia-Caballero, L. Sokol, A. Cuypers & P. CARMELIET
Publicado en: International Journal of Molecular Sciences, Edición Vol23/Edición19, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911052

Protocols for endothelial cell isolation from mouse tissues: brain, choroid, lung, and muscle

Autores: N.V. Conchinha, L. Sokol, L.A. Teuwen, K. Veys, S.J. Dumas, E. Meta, M. Garcia-Caballero, V. Geldhof, R. Chen, L. Treps, M. Borri, P. de Zeeuw, K.D. Falkenberg, C. Dubois, M. Parys, L. de Rooij, K. Rohlenova, J. Goveia, L. Schoonjans, M. Dewerchin, G. Eelen, X. Li, J. Kalucka & P. CARMELIET.
Publicado en: Star Protocols, Edición Vollume 2 Edición 3, 2021, Página(s) 100508, ISSN 2666-1667
Editor: Elsevier
DOI: 10.1016/j.xpro.2021.100508

Protocols for endothelial cell isolation from mouse tissues: small intestine, colon, heart, and liver

Autores: L. Sokol, V. Geldhof, M. Garcia-Caballero, N.V. Conchinha, S.J. Dumas, E. Meta, L.A. Teuwen, K. Veys, R. Chen, L. Treps, M. Borri, P. de Zeeuw, K.D. Falkenberg, C. Dubois, M. Parys, L. de Rooij, J. Goveia, K. Rohlenova, L. Schoonjans, M. Dewerchin, G. Eelen, X. Li, J. Kalucka, & P. CARMELIET.
Publicado en: Star Protocols, Edición Volume 2 Edición 2, 2021, Página(s) 100489, ISSN 2666-1667
Editor: Elsevier
DOI: 10.1016/j.xpro.2021.100489

Tumor vessel co-option probed by single-cell analysis.

Autores: L.A. Teuwen, L. De Rooij, A. Cuypers, K. Rohlenova, S.J. Dumas, M. Garcia-Caballero, E. Meta, J. Amersfoort, F. Taverna, L.M. Becker, N. Veiga, A.R. Cantelmo, V. Geldhof, N.V. Conchinha, J. Kalucka, L. Treps, L.C. Conradi, S. Khan, T.K. Karakach, S. Soenen, S. Vinckier, L. Schoonjans, G. Eelen, S. Van Laere, M. Dewerchin, L. Dirix, M. Mazzone, Y. Luo, P. Vermeulen & P. CARMELIET
Publicado en: Cell Reports, Edición Volume 35 Edición 11, 2021, Página(s) ARTN 109253, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109253

Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity

Autores: K. Veys, Z. Fan, M. Ghobrial, A. Bouche, M. Garcia-Caballero, K. Vriens, N. V. Conchinha, A. Seuwen, F. Schlegel, T. Gorski, M. Crabbe, P. Gilardoni, R. Ardicoglu, J. Schaffenrath, C. Casteels, G. De Smet, I. Smolders, K. Van Laere, E. D. Abel, S. M. Fendt, A. Schroeter, J. Kalucka, A. R. Cantelmo, T. Walchli, A. Keller, P. CARMELIET & K. De Bock
Publicado en: Circulation Research, 2020, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.316463

Endothelial metabolism going single

Autores: A. Subramanian, L. M. Becker & P. CARMELIET
Publicado en: NATURE METABOLISM, Edición Volume 3 Edición 5, 2021, Página(s) 593-594, ISSN 2522-5812
Editor: NATURE RESEARCH
DOI: 10.1038/s42255-021-00399-3

Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis

Autores: R. Tillie, J. De Bruijn, J. Perales-Paton, L. Temmerman, Y. Ghosheh, K. Van Kuijk, M.J. Gijbels, P. CARMELIET, K. Ley, J. Saez-Rodriguez & J.C. Sluimer
Publicado en: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, Edición Volume 9, 2021, Página(s) 11 pages ARTN 695684, ISSN 2296-634X
Editor: FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.695684

Endothelial CFTR dysfunction and its involvement in the pathogenesis of pulmonary arterial hypertension

Autores: M. Declercq, L. Treps, S. Bousfia, P. CARMELIET & P. Witters
Publicado en: EUROPEAN RESPIRATORY JOURNAL, Edición Volume 58 Edición 2, 2021, Página(s) ARTN 2101645, ISSN 0903-1936
Editor: European Respiratory Society
DOI: 10.1183/13993003.01645-2021

Angiogenesis goes computational – The future way forward to discover new angiogenic targets?

Autores: A. Subramanian, P. Zakeri, M. Mousa, H. Alnaqbi, F. Y. Alshamsi, L. Bettoni, E. Damiani, H. Alsafar, Y. Saeys & P. CARMELIET
Publicado en: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, Edición Vol 20, 2022, Página(s) 5235-5255, ISSN 2001-0370
Editor: Elsevier
DOI: 10.1016/j.csbj.2022.09.019

Vasculogenesis in kidney organoids upon transplantation

Autores: M.S. Koning, S. J. Dumas, M. C. Avramut, R. I. Koning, E. Meta, et al, P. Carmeliet, et al
Publicado en: NPJ Regen Med, 2022, ISSN 2057-3995
Editor: Nature Portfolio
DOI: 10.1038/s41536-022-00237-4

Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancer

Autores: an Nyen, T., M. Planque, L. van Wagensveld, J. A. G. Duarte, E. A. Zaal, A. Talebi, M. Rossi, P. R. Korner, et al, P. Carmeliet, et al
Publicado en: Nature Communications, Edición Vol 13, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32272-6

Macrophage-derived glutamine boosts satellite cells and muscle regeneration.

Autores: M. Shang, F. Cappellesso, R. Amorim, J. Serneels, F. Virga, G. Eelen, S. Carobbio, M. Y. Rincon, P. Maechler, K. De Bock, P. C. Ho, M. Sandri, B. Ghesquiere, P. CARMELIET, M. Di Matteo, E. Berardi & M. Mazzone. Macrophage-derived glutamine boosts satellite cells and muscle regeneration.
Publicado en: Nature, 2020, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2857-9

Glutamine Metabolism in Osteoprogenitors Is Required for Bone Mass Accrual and PTH-Induced Bone Anabolism in Male Mice

Autores: S. Stegen, C. S. Devignes, S. Torrekens, R. Van Looveren, P. CARMELIET & G. Carmeliet.
Publicado en: JOURNAL OF BONE AND MINERAL RESEARCH, Edición Volume 36 Edición 3, 2021, Página(s) 604-616, ISSN 0884-0431
Editor: American Society for Bone and Mineral Research
DOI: 10.1002/jbmr.4219

Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice.

Autores: J.A.F. Demandt, K. van Kuijk, T.L. Theelen, E. Marsch, S.P. Heffron, E.A. Fisher, P. CARMELIET, E.A.L. Biessen, and J.C. Sluimer.
Publicado en: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, Edición Volume 9, 2021, Página(s) 10 pages ARTN 664258, ISSN 2296-634X
Editor: FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.664258

Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain

Autores: T. Walchli, J. Bisschop, A. Miettinen, A. Ulmann-Schuler, C. Hintermuller, E.P. Meyer, T. Krucker, R. Walchli, P.P. Monnier
Publicado en: NATURE PROTOCOLS, Edición Volume 16 Edición 10, 2021, Página(s) 4564, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-021-00587-1

c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Autores: J. Leslie, M. G. Macia, S. Luli, J. C. Worrell, W. J. Reilly, H. L. Paish, A. Knox, B. S. Barksby, L. M. Gee, M. Y. W. Zaki, A. L. Collins, R. A. Burgoyne, R. Cameron, C. Bragg, X. Xu, G. W. Chung, C. D. A. Brown, A. D. Blanchard, C. B. Nanthakumar, M. Karsdal, S. M. Robinson, D. M. Manas, G. Sen, J. French, S. A. White, S. Murphy, M. Trost, J. L. Zakrzewski, U. Klein, R. F. Schwabe, I. Mederacke,
Publicado en: Nature Metabolism, 2020, ISSN 2522-5812
Editor: Nature
DOI: 10.1038/s42255-020-00306-2

Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level

Autores: F. Wang, P. Ding, X. Liang, et al, P. Carmeliet, et al
Publicado en: Nature communications, Edición Vol13,3620, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34498-w

CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation

Autores: Fernandez-Garcia, J., F. Franco, S. Parik, P. Altea-Manzano, A. A. Pane, D. Broekaert, J. van Elsen, I. Vermeire, T. Schalley, M. Planque, T. van Brussel, R. Schepers, E. Modave, T. K. Karakach, P. CARMELIET, D. Lambrechts, P. C. Ho, and S. M. Fendt
Publicado en: Cell Reports, Edición Volume 41, Edición7, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111639

Gas6 is dispensable for pubertal mammary gland development.

Autores: Mills, Kylie L.; Gomes, Angelica M.; Standlee, Courtney R.; Rojo, Michelle D.; Carmeliet, Peter; Lin, Zhen; Machado, Heather L.
Publicado en: PLoS ONE, Edición 1, 2018, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0208550

Protocols for endothelial cell isolation from mouse tissues: kidney, spleen, and testis.

Autores: S.J. Dumas, E. Meta, N.V. Conchinha, L. Sokol, R. Chen, M. Borri, L.A. Teuwen, K. Veys, M. Garcia-Caballero, V. Geldhof, L. Treps, P. de Zeeuw, K.D. Falkenberg, C. Dubois, M. Parys, L. de Rooij, K. Rohlenova, J. Goveia, L. Schoonjans, M. Dewerchin, G. Eelen, X. Li, J. Kalucka & P. CARMELIET
Publicado en: Star Protocols, Edición Volume 2 Edición 3, 2021, Página(s) 100523, ISSN 2666-1667
Editor: Elsevier
DOI: 10.1016/j.xpro.2021.100523

The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors

Autores: A. De Zutter, H. Crijns, N. Berghmans, M. Garcia-Caballero, L. Vanbrabant, N. Portner, V. Vanheule, P. Verscheure, M.M. Siddiquei, A.M. Abu El-Asrar, P. CARMELIET, P. Van Wielendaele, I. De Meester, J. Van Damme, P. Proost & S. Struyf.
Publicado en: Cancers, Edición volume 13 Edición 20, 2021, Página(s) ARTN 5090, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13205090

De novo serine synthesis regulates chondrocyte proliferation during bone development and repair

Autores: Stegen, S., S. Loopmans, I. Stockmans, K. Moermans, P. CARMELIET & G. Carmeliet
Publicado en: Bone Research, 2021, ISSN 2095-4700
Editor: Sichuan University Press
DOI: 10.1038/s41413-021-00185-7

Metabolic signatures of distinct endothelial phenotypes

Autores: S.J. Dumas, M. Garcia-Caballero & P. CARMELIET
Publicado en: TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2020, ISSN 1043-2760
Editor: Elsevier BV
DOI: 10.1016/j.tem.2020.05.009

Endothelial cell metabolism:: an update anno 2017

Autores: LA Teuwen, N Draoui, C Dubois, P Carmeliet
Publicado en: Current Opinion in Hematology, 2017, ISSN 1065-6251
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/moh.0000000000000335

Deciphering Endothelial Heterogeneity in Health and Disease at Single Cell Resolution: Progress and Perspectives.

Autores: Becker, L. M., S. H. Chen, J. Rodor, Lpmh de Rooij, A. H. Baker, & P. CARMELIET.
Publicado en: CARDIOVASCULAR RESEARCH, 2021, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvac018

Prominin-1 controls stem cell activation by orchestrating ciliary dynamics

Autores: Singer, Donald; Thamm, Kristina; Zhuang, Heng; Karbanová, Jana; Gao, Yan; Walker, Jemma Victoria; Jin, Heng; Wu, Xiangnan; Coveney, Clarissa R; Marangoni, Pauline; Lu, Dongmei; Grayson, Portia Rebecca Clare; Gulsen, Tulay; Liu, Karen J; Ardu, Stefano; Wann, Angus KT; Luo, Shouqing; Zambon, Alexander C; Jetten, Anton M; Tredwin, Christopher; Klein, Ophir D; Attanasio, Massimo; Carmeliet, Peter; Hu
Publicado en: Embo Journal, Edición 1, 2019, ISSN 1460-2075
Editor: Wiley
DOI: 10.15252/embj.201899845

A Role for the Vascular Endothelium in Post-Acute COVID-19?

Autores: de Rooij, Lpmh, L. M. Becker & P. CARMELIET
Publicado en: CIRCULATION, Edición Volume 145 Edición 20, 2021, Página(s) 1503-1505, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.059231

EndoDB: a database of endothelial cell transcriptomics data

Autores: Shawez Khan, Federico Taverna, Katerina Rohlenova, Lucas Treps, Vincent Geldhof, Laura de Rooij, Liliana Sokol, Andreas Pircher, Lena-Christin Conradi, Joanna Kalucka, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Tobias Karakach, Xuri Li, Jermaine Goveia, Peter Carmeliet
Publicado en: Nucleic Acids Research, Edición 47/D1, 2018, Página(s) D736-D744, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gky997

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism

Autores: Nihed Draoui, Pauline de Zeeuw, Peter Carmeliet
Publicado en: Open Biology, Edición 7/12, 2017, Página(s) 170219, ISSN 2046-2441
Editor: Royal Society Publishing
DOI: 10.1098/rsob.170219

Endothelial Cell Metabolism

Autores: Guy Eelen, Pauline de Zeeuw, Lucas Treps, Ulrike Harjes, Brian W. Wong, Peter Carmeliet
Publicado en: Physiological Reviews, Edición 98/1, 2018, Página(s) 3-58, ISSN 0031-9333
Editor: American Physiological Society
DOI: 10.1152/physrev.00001.2017

COVID-19: the vasculature unleashed

Autores: Laure-Anne Teuwen, Vincent Geldhof, Alessandra Pasut, Peter Carmeliet
Publicado en: Nature Reviews Immunology, 2020, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-020-0343-0

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

Autores: Joanna Kalucka, Laura Bierhansl, Nadine Vasconcelos Conchinha, Rindert Missiaen, Ilaria Elia, Ulrike Brüning, Samantha Scheinok, Lucas Treps, Anna Rita Cantelmo, Charlotte Dubois, Pauline de Zeeuw, Jermaine Goveia, Annalisa Zecchin, Federico Taverna, Francisco Morales-Rodriguez, Aleksandra Brajic, Lena-Christin Conradi, Sandra Schoors, Ulrike Harjes, Kim Vriens, Gregor-Alexander Pilz, Rongyuan Ch
Publicado en: Cell Metabolism, Edición 28/6, 2018, Página(s) 881-894.e13, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2018.07.016

Blockade of myeloid-derived suppressor cell expansion with all-trans retinoic acid increases the efficacy of anti-angiogenic therapy

Autores: Raimund Bauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ines Miranda Santos, Federico Taverna, Meike Kuhlencord, Victoria Gensch, Sarina Päsler, Stefan Vinckier, Johanna M Brandner, Klaus Pantel, Carsten Bokemeyer, Thomas Vogl, Johannes Roth, Peter Carmeliet, Sonja Loges
Publicado en: Cancer Research, 2018, Página(s) canres.3415.2017, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-17-3415

RAISEing VEGF-D’s importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients

Autores: P. Carmeliet, X. Li, L. Treps, L.-C. Conradi, S. Loges
Publicado en: Annals of Oncology, Edición 29/3, 2018, Página(s) 529-532, ISSN 0923-7534
Editor: Oxford University Press
DOI: 10.1093/annonc/mdy028

How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development

Autores: Laure-Anne Teuwen, Vincent Geldhof, Peter Carmeliet
Publicado en: Developmental Biology, Edición 447/1, 2019, Página(s) 90-102, ISSN 0012-1606
Editor: Academic Press
DOI: 10.1016/J.YDBIO.2017.12.001

The metabolic engine of endothelial cells

Autores: Kim D. Falkenberg, Katerina Rohlenova, Yonglun Luo, Peter Carmeliet
Publicado en: Nature Metabolism, Edición 1/10, 2019, Página(s) 937-946, ISSN 2522-5812
Editor: Springer Nature
DOI: 10.1038/s42255-019-0117-9

Metabolic Pathways Fueling the Endothelial Cell Drive

Autores: Xuri Li, Anil Kumar, Peter Carmeliet
Publicado en: Annual Review of Physiology, Edición 81/1, 2019, Página(s) 483-503, ISSN 0066-4278
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-physiol-020518-114731

The role of endothelial cells in cystic fibrosis

Autores: M. Declercq, L. Treps, P. Carmeliet, P. Witters
Publicado en: Journal of Cystic Fibrosis, Edición 18/6, 2019, Página(s) 752-761, ISSN 1569-1993
Editor: Elsevier BV
DOI: 10.1016/j.jcf.2019.07.005

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Autores: Joanna Kalucka, Laura P.M.H. de Rooij, Jermaine Goveia, Katerina Rohlenova, Sébastien J. Dumas, Elda Meta, Nadine V. Conchinha, Federico Taverna, Laure-Anne Teuwen, Koen Veys, Melissa García-Caballero, Shawez Khan, Vincent Geldhof, Liliana Sokol, Rongyuan Chen, Lucas Treps, Mila Borri, Pauline de Zeeuw, Charlotte Dubois, Tobias K. Karakach, Kim D. Falkenberg, Magdalena Parys, Xiangke Yin, Stefan
Publicado en: Cell, Edición 180/4, 2020, Página(s) 764-779.e20, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.01.015

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Autores: Jermaine Goveia, Katerina Rohlenova, Federico Taverna, Lucas Treps, Lena-Christin Conradi, Andreas Pircher, Vincent Geldhof, Laura P.M.H. de Rooij, Joanna Kalucka, Liliana Sokol, Melissa García-Caballero, Yingfeng Zheng, Junbin Qian, Laure-Anne Teuwen, Shawez Khan, Bram Boeckx, Els Wauters, Herbert Decaluwé, Paul De Leyn, Johan Vansteenkiste, Birgit Weynand, Xavier Sagaert, Erik Verbeken, Albert
Publicado en: Cancer Cell, Edición 37/1, 2020, Página(s) 21-36.e13, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2019.12.001

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

Autores: Katerina Rohlenova, Jermaine Goveia, Melissa García-Caballero, Abhishek Subramanian, Joanna Kalucka, Lucas Treps, Kim D. Falkenberg, Laura P.M.H. de Rooij, Yingfeng Zheng, Lin Lin, Liliana Sokol, Laure-Anne Teuwen, Vincent Geldhof, Federico Taverna, Andreas Pircher, Lena-Christin Conradi, Shawez Khan, Steve Stegen, Dena Panovska, Frederik De Smet, Frank J.T. Staal, Rene J. Mclaughlin, Stefan Vinc
Publicado en: Cell Metabolism, Edición 31/4, 2020, Página(s) 862-877.e14, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.03.009

BIOMEX: an interactive workflow for (single cell) omics data interpretation and visualization

Autores: Federico Taverna, Jermaine Goveia, Tobias K Karakach, Shawez Khan, Katerina Rohlenova, Lucas Treps, Abhishek Subramanian, Luc Schoonjans, Mieke Dewerchin, Guy Eelen, Peter Carmeliet
Publicado en: Nucleic Acids Research, Edición 48/W1, 2020, Página(s) W385-W394, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa332

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

Autores: Guy Eelen, Charlotte Dubois, Anna Rita Cantelmo, Jermaine Goveia, Ulrike Brüning, Michael DeRan, Gopala Jarugumilli, Jos van Rijssel, Giorgio Saladino, Federico Comitani, Annalisa Zecchin, Susana Rocha, Rongyuan Chen, Hongling Huang, Saar Vandekeere, Joanna Kalucka, Christian Lange, Francisco Morales-Rodriguez, Bert Cruys, Lucas Treps, Leanne Ramer, Stefan Vinckier, Katleen Brepoels, Sabine Wyns,
Publicado en: Nature, Edición 561/7721, 2018, Página(s) 63-69, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-018-0466-7

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

Autores: Saar Vandekeere, Charlotte Dubois, Joanna Kalucka, Mark R. Sullivan, Melissa García-Caballero, Jermaine Goveia, Rongyuan Chen, Frances F. Diehl, Libat Bar-Lev, Joris Souffreau, Andreas Pircher, Saran Kumar, Stefan Vinckier, Yoshio Hirabayashi, Shigeki Furuya, Luc Schoonjans, Guy Eelen, Bart Ghesquière, Eli Keshet, Xuri Li, Matthew G. Vander Heiden, Mieke Dewerchin, Peter Carmeliet
Publicado en: Cell Metabolism, Edición 28/4, 2018, Página(s) 573-587.e13, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2018.06.009

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

Autores: Ulrike Bruning, Francisco Morales-Rodriguez, Joanna Kalucka, Jermaine Goveia, Federico Taverna, Karla C.S. Queiroz, Charlotte Dubois, Anna Rita Cantelmo, Rongyuan Chen, Stefan Loroch, Evy Timmerman, Vanessa Caixeta, Katarzyna Bloch, Lena-Christin Conradi, Lucas Treps, An Staes, Kris Gevaert, Andrew Tee, Mieke Dewerchin, Clay F. Semenkovich, Francis Impens, Birgit Schilling, Eric Verdin, Johannes V
Publicado en: Cell Metabolism, Edición 28/6, 2018, Página(s) 866-880.e15, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2018.07.019

Mitochondrial respiration supports autophagy to provide stress resistance during quiescence.

Autores: Magalhaes-Novais, S., J. Blecha, R. Naraine, J. Mikesova, P. Abaffy, A. Pecinova, M. Milosevic, R. Bohuslavova, J. Prochazka, S. Khan, E. Novotna, R. Sindelka, R. Machan, M. Dewerchin, E. Vlcak, J. Kalucka, S. Stemberkova Hubackova, A. Benda, J. Goveia, T. Mracek, C. Barinka, P. CARMELIET, J. Neuzil, K. Rohlenova & J. Rohlena.
Publicado en: AUTOPHAGY, 2021, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2022.2038898

Tumor vessel co-option: The past & the future

Autores: A. Cuypers, A. K. Truong, L. M. Becker, P. Saavedra-Garcia, & P. CARMELIET
Publicado en: Frontiers in Oncology, Edición Vol 12, 2022, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.965277

Basic and Therapeutic Aspects of Angiogenesis Updated

Autores: Eelen, Guy; Treps, Lucas; Li, Xuri; Carmeliet, Peter
Publicado en: CIRCULATION RESEARCH, 2020, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316851

Endothelial cell plasticity at the single-cell level

Autores: A. Pasut, Lisa M. Becker, A. Cuypers & P. CARMELIET
Publicado en: Angiogenesis, Edición volume 24 Edición 2, 2021, Página(s) 311-326, ISSN 0969-6970
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10456-021-09797-3

The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single cell resolution

Autores: Lpmh de Rooij, L. M. Becker, L. A. Teuwen, B. Boeckx, S. Jansen, S. Feys, S. Verleden, L. Liesenborghs, et al & P Carmeliet
Publicado en: Cardiovascular Research, Edición cva139, 2022, ISSN 1755-3245
Editor: Oxford Univ Press
DOI: 10.1093/cvr/cvac139

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation

Autores: Sébastien J. Dumas, Elda Meta, Mila Borri, Jermaine Goveia, Katerina Rohlenova, Nadine V. Conchinha, Kim Falkenberg, Laure-Anne Teuwen, Laura de Rooij, Joanna Kalucka, Rongyuan Chen, Shawez Khan, Federico Taverna, Weisi Lu, Magdalena Parys, Carla De Legher, Stefan Vinckier, Tobias K. Karakach, Luc Schoonjans, Lin Lin, Lars Bolund, Mieke Dewerchin, Guy Eelen, Ton J. Rabelink, Xuri Li, Yonglun Luo
Publicado en: Journal of the american society of nephrology, Edición 31 (1), 2020, Página(s) 118-138, ISSN 1046-6673
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2019080832

Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype

Autores: M. Declercq, P. de Zeeuw, N. Vasconcelos Conchinha, V. Geldhof, A. S. Ramalho, M. Garcia-Caballero, K. Brepoels, M. Ensinck, M. S. Carlon, M. J. Bird, S. Vinckier, M. Proesmans, F. Vermeulen, L. Dupont, B. Ghesquiere, M. Dewerchin, P. CARMELIET, D. Cassiman, L. Treps, G. Eelen & P. Witters
Publicado en: EUROPEAN RESPIRATORY JOURNAL, Edición Volume 57 Edición 4, 2021, Página(s) ARTN 2000261, ISSN 0903-1936
Editor: European Respiratory Society
DOI: 10.1183/13993003.00261-2020

Phenotypic diversity and metabolic specialization of renal endothelial cells

Autores: S.J. Dumas, E. Meta, M. Borri, Y. Luo, X. Li, T.J. Rabelink & .P. CARMELIET.
Publicado en: NATURE REVIEWS NEPHROLOGY, Edición volume 17 Edición 7, 2021, ISSN 1759-5061
Editor: Nature Publishing Group
DOI: 10.1038/s41581-021-00411-9

Immunomodulation by endothelial cells – partnering up with the immune system?

Autores: J. Amersfoort, G. Eelen & P. CARMELIET
Publicado en: NATURE REVIEWS IMMUNOLOGY, 2021, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-022-00694-4

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

Autores: M.D. Mana, A.M. Hussey, C.N. Tzouanas, S. Imada, Y. Barrera Millan, D. Bahceci, D.R. Saiz, A.T. Webb, C.A. Lewis, P. CARMELIET, M.M. Mihaylova, A.K. Shalek, and O.H. Yilmaz
Publicado en: CELL REPORTS, Edición Volume 35 Edición 10, 2021, Página(s) ARTN 109212, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109212

Analysis of Endothelial Fatty Acid Metabolism Using Tracer Metabolomics.

Autores: Joanna Kalucka; Bart Ghesquière; Sarah-Maria Fendt; Peter Carmeliet
Publicado en: Methods in Molecular Biology, Edición 2, 2019, ISBN 978-1-4939-9235-5
Editor: HUMANA PRESS INC
DOI: 10.1007/978-1-4939-9236-2_16

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