New Chemical Tools for Precision Glycotherapy

Project Information

GlycoEdit

Grant agreement ID: 758913

DOI 10.3030/758913

Project closed

EC signature date 25 October 2017

Start date 1 November 2017

End date 30 April 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

STICHTING RADBOUD UNIVERSITEIT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (21)

Fluorinated rhamnosides inhibit cellular fucosylation

Author(s): Johan F. A. Pijnenborg, Emiel Rossing, Jona Merx, Marek J. Noga, Willem H. C. Titulaer, Nienke Eerden, Raisa Veizaj, Paul B. White, Dirk J. Lefeber & Thomas J. Boltje
Published in: nature communication, 2021, ISSN 2049-3630
Publisher: springer nature
DOI: 10.1038/s41467-021-27355-9

Structure–Activity Relationship of Fluorinated Sialic Acid Inhibitors for Bacterial Sialylation

Author(s): Sam J. Moons, Emiel Rossing, Jurriaan J. A. Heming, Mathilde A. C. H. Janssen, Monique van Scherpenzeel, Dirk J. Lefeber, Marien I. de Jonge, Jeroen D. Langereis & Thomas J. Boltje
Published in: bioconjugate chem, 2021, ISSN 2049-3630
Publisher: acs
DOI: 10.1021/acs.bioconjchem.1c00194

Chemical tools to track and perturb the expression of sialic acid and fucose monosaccharides

Author(s): Emiel Rossing; Johan F. A. Pijnenborg; Thomas J. Boltje
Published in: Chemical Communications, 58, 12139 - 12150, Issue 1, 2022, ISSN 2049-3630
Publisher: RSC
DOI: 10.1039/d2cc04275d

Selective N-Deacetylation and Functionalization of Aminosugars.

Author(s): Sam J. Moons, Alexander D. Robertson, Dr. Thomas J. Boltje
Published in: ejoc, 2022, ISSN 2049-3630
Publisher: wiley
DOI: 10.1002/ejoc.202200659

Sialic acid O-acetylation: From biosynthesis to roles in health and disease.

Author(s): Eline A. Visser; Sam J. Moons; Suzanne B. P. E. Timmermans; Heleen de Jong; Thomas J. Boltje; Christian Büll
Published in: VOLUME=297;STARTPAGE=1;ENDPAGE=19;ISSN=0021-9258;TITLE=Journal of Biological Chemistry, Issue 1, 2021, ISSN 2049-3630
Publisher: jbc
DOI: 10.1016/j.jbc.2021.100906

Cellular Fucosylation Inhibitors Based on Fluorinated Fucose‐1‐phosphates**

Author(s): Johan F. A. Pijnenborg; Eline A. Visser; Marek J Noga; Emiel Rossing; Raisa Veizaj; Dirk Lefeber; Christian Büll; Thomas J. Boltje
Published in: urn:issn:0947-6539, Issue 1, 2021, ISSN 2049-3630
Publisher: Wiley
DOI: 10.1002/chem.202005359

Sialic acid blockade in dendritic cells enhances CD8+ T cell responses by facilitating high-avidity interactions

Author(s): Balneger, N.; Cornelissen, L. A. M.; Wassink, M.; Moons, S. J.; Boltje, T. J.; Bar-Ephraim, Y. E.; Das, K. K.; Søndergaard, J. N.; Büll, C.; Adema, G. J.
Published in: Cellular and Molecular Life Sciences, Issue 1, 2022, ISSN 2049-3630
Publisher: nature springer
DOI: 10.1007/s00018-021-04027-x

The Glycosylation Mechanisms of 6,3-Uronic Acid Lactones

Author(s): Hidde Elferink, Rens A. Mensink, Wilke W. A. Castelijns, Oscar Jansen, Jeroen P. J. Bruekers, Jonathan Martens, Jos Oomens, Anouk M. Rijs, Thomas J. Boltje
Published in: Angewandte Chemie International Edition, Issue 58/26, 2019, Page(s) 8746-8751, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201902507

Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N‐ Acetylneuraminate Lyase in a Continuous Flow Reactor

Author(s): Victor R. L. J. Bloemendal, Sam J. Moons, Jurriaan J. A. Heming, Mohamed Chayoua, Olaf Niesink, Jan C. M. van Hest, Thomas J. Boltje, Floris P. J. T. Rutjes
Published in: Advanced Synthesis & Catalysis, 2019, ISSN 1615-4150
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.201900146

Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs

Author(s): Sam J Moons, Gosse J Adema, Max TGM Derks, Thomas J Boltje, Christian Büll
Published in: Glycobiology, 2019, ISSN 1460-2423
Publisher: oxford academic
DOI: 10.1093/glycob/cwz026

Direct Experimental Characterization of Glycosyl Cations by Infrared Ion Spectroscopy

Author(s): Hidde Elferink, Marion E. Severijnen, Jonathan Martens, Rens A. Mensink, Giel Berden, Jos Oomens, Floris P. J. T. Rutjes, Anouk M. Rijs, Thomas J. Boltje
Published in: Journal of the American Chemical Society, Issue 140/19, 2018, Page(s) 6034-6038, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b01236

Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids

Author(s): Torben Heise, Johan F. A. Pijnenborg, Christian Büll, Niek van Hilten, Esther D. Kers-Rebel, Natasja Balneger, Hidde Elferink, Gosse J. Adema, Thomas J. Boltje
Published in: Journal of Medicinal Chemistry, Issue 62/2, 2019, Page(s) 1014-1021, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.8b01757

α-Selective Glycosylation with β-Glycosyl Sulfonium Ions Prepared via Intramolecular Alkylation

Author(s): Sam J. Moons, Rens A. Mensink, Jeroen P. J. Bruekers, Maurits L. A. Vercammen, Laura M. Jansen, Thomas J. Boltje
Published in: The Journal of Organic Chemistry, Issue 84/7, 2019, Page(s) 4486-4500, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.9b00022

C-2 auxiliaries for stereoselective glycosylation based on common additive functional groups

Author(s): Frank F. J. de Kleijne, Sam J. Moons, Paul B. White, Thomas J. Boltje
Published in: Organic & Biomolecular Chemistry, Issue 18/6, 2020, Page(s) 1165-1184, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9ob02700a

Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions

Author(s): Thomas Hansen, Hidde Elferink, Jacob M. A. van Hengst, Kas J. Houthuijs, Wouter A. Remmerswaal, Alexandra Kromm, Giel Berden, Stefan van der Vorm, Anouk M. Rijs, Hermen S. Overkleeft, Dmitri V. Filippov, Floris P. J. T. Rutjes, Gijsbert A. van der Marel, Jonathan Martens, Jos Oomens, Jeroen D. C. Codée, Thomas J. Boltje
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16362-x

Growth on Carbohydrates from Carbonaceous Meteorites Alters the Immunogenicity of Environment-Derived Bacterial Pathogens

Author(s): Jorge Domínguez-Andrés, Marc Eleveld, Georgios Renieris, Thomas J. Boltje, Rob J. Mesman, Laura van Niftrik, Sam J. Moons, Petra Rettberg, Jos W.M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Huub J.M. Op den Camp, Marien I. de Jonge, Mihai G. Netea
Published in: Astrobiology, 2020, ISSN 1531-1074
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ast.2019.2173

GlycoCAP: A Cell-Free, Bacterial Glycosylation Platform for Building Clickable Azido-Sialoglycoproteins

Author(s): Ariel Helms Thames, Sam J. Moons, Derek A. Wong, Thomas J. Boltje, Bruce S. Bochner, and Michael C. Jewett*
Published in: acs synthetic biology, 2023, ISSN 2049-3630
Publisher: acs
DOI: 10.1021/acssynbio.3c00017

Structure-Activity Relationship of Metabolic Sialic Acid Inhibitors and Labeling Reagents

Author(s): Sam J. Moons; Emiel Rossing; Mathilde A. C. H. Janssen; Torben Heise; Christian Büll; Gosse J. Adema; Thomas J. Boltje
Published in: VOLUME=17;STARTPAGE=590;ENDPAGE=597;ISSN=1554-8929;TITLE=Acs Chemical Biology, Issue 1, 2022, ISSN 2049-3630
Publisher: acs
DOI: 10.1021/acschembio.1c00868

UV light-induced spatial loss of sialic acid capping using a photoactivatable sialyltransferase inhibitor

Author(s): Sam J. Moons, Daniël L.A.H. Hornikx,‡b Mikkel K. M. Aasted,c Johan F.A. Pijnenborg,a Matteo Calzari,a Paul B. White,a Yoshiki Narimatsu,c Henrik Clausen,c Hans H. Wandall,c Thomas J. Boltje ORCID logo *a and Christian Büll ORCID logo *bc
Published in: rsc chemical biology, 2023, ISSN 2049-3630
Publisher: rsc
DOI: 10.1039/d3cb00006k

Amadori rearrangement product as potential biomarkers for inborn errors of amino-acid metabolism

Author(s): Rianne E. van Outersterp, Sam J. Moons, Udo F. H. Engelke, Herman Bentlage, Tessa M. A. Peters, Arno van Rooij, Marleen C. D. G. Huigen, Siebolt de Boer, Ed van der Heeft, Leo A. J. Kluijtmans, Clara D. M. van Karnebeek, Ron A. Wevers , Giel Berden, Jos Oomens, Thomas J. Boltje, Karlien L. M. Coene & Jonathan Martens
Published in: communications biology, 2021, ISSN 2049-3630
Publisher: springer nature
DOI: 10.1038/s42003-021-01909-5

Sialic acids in gynaecological cancer development and progression: impact on diagnosis and treatment

Author(s): Anna Y. Berghuis, Johan F. A. Pijnenborg, Thomas J. Boltje, Johanna M. A. Pijnenborg
Published in: molecular cancer biology, 2021, ISSN 2049-3630
Publisher: wilet
DOI: 10.1002/ijc.33866