New Chemical Tools for Precision Glycotherapy

Informazioni relative al progetto

GlycoEdit

ID dell’accordo di sovvenzione: 758913

DOI

10.3030/758913

Progetto chiuso

Data della firma CE 25 Ottobre 2017

Data di avvio 1 Novembre 2017

Data di completamento 30 Aprile 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 500 000,00

Contributo UE

€ 1 500 000,00

Coordinato da

STICHTING RADBOUD UNIVERSITEIT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (21)

Fluorinated rhamnosides inhibit cellular fucosylation

Autori: Johan F. A. Pijnenborg, Emiel Rossing, Jona Merx, Marek J. Noga, Willem H. C. Titulaer, Nienke Eerden, Raisa Veizaj, Paul B. White, Dirk J. Lefeber & Thomas J. Boltje
Pubblicato in: nature communication, 2021, ISSN 2049-3630
Editore: springer nature
DOI: 10.1038/s41467-021-27355-9

Structure–Activity Relationship of Fluorinated Sialic Acid Inhibitors for Bacterial Sialylation

Autori: Sam J. Moons, Emiel Rossing, Jurriaan J. A. Heming, Mathilde A. C. H. Janssen, Monique van Scherpenzeel, Dirk J. Lefeber, Marien I. de Jonge, Jeroen D. Langereis & Thomas J. Boltje
Pubblicato in: bioconjugate chem, 2021, ISSN 2049-3630
Editore: acs
DOI: 10.1021/acs.bioconjchem.1c00194

Chemical tools to track and perturb the expression of sialic acid and fucose monosaccharides

Autori: Emiel Rossing; Johan F. A. Pijnenborg; Thomas J. Boltje
Pubblicato in: Chemical Communications, 58, 12139 - 12150, Numero 1, 2022, ISSN 2049-3630
Editore: RSC
DOI: 10.1039/d2cc04275d

Selective N-Deacetylation and Functionalization of Aminosugars.

Autori: Sam J. Moons, Alexander D. Robertson, Dr. Thomas J. Boltje
Pubblicato in: ejoc, 2022, ISSN 2049-3630
Editore: wiley
DOI: 10.1002/ejoc.202200659

Sialic acid O-acetylation: From biosynthesis to roles in health and disease.

Autori: Eline A. Visser; Sam J. Moons; Suzanne B. P. E. Timmermans; Heleen de Jong; Thomas J. Boltje; Christian Büll
Pubblicato in: VOLUME=297;STARTPAGE=1;ENDPAGE=19;ISSN=0021-9258;TITLE=Journal of Biological Chemistry, Numero 1, 2021, ISSN 2049-3630
Editore: jbc
DOI: 10.1016/j.jbc.2021.100906

Cellular Fucosylation Inhibitors Based on Fluorinated Fucose‐1‐phosphates**

Autori: Johan F. A. Pijnenborg; Eline A. Visser; Marek J Noga; Emiel Rossing; Raisa Veizaj; Dirk Lefeber; Christian Büll; Thomas J. Boltje
Pubblicato in: urn:issn:0947-6539, Numero 1, 2021, ISSN 2049-3630
Editore: Wiley
DOI: 10.1002/chem.202005359

Sialic acid blockade in dendritic cells enhances CD8+ T cell responses by facilitating high-avidity interactions

Autori: Balneger, N.; Cornelissen, L. A. M.; Wassink, M.; Moons, S. J.; Boltje, T. J.; Bar-Ephraim, Y. E.; Das, K. K.; Søndergaard, J. N.; Büll, C.; Adema, G. J.
Pubblicato in: Cellular and Molecular Life Sciences, Numero 1, 2022, ISSN 2049-3630
Editore: nature springer
DOI: 10.1007/s00018-021-04027-x

The Glycosylation Mechanisms of 6,3-Uronic Acid Lactones

Autori: Hidde Elferink, Rens A. Mensink, Wilke W. A. Castelijns, Oscar Jansen, Jeroen P. J. Bruekers, Jonathan Martens, Jos Oomens, Anouk M. Rijs, Thomas J. Boltje
Pubblicato in: Angewandte Chemie International Edition, Numero 58/26, 2019, Pagina/e 8746-8751, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201902507

Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N‐ Acetylneuraminate Lyase in a Continuous Flow Reactor

Autori: Victor R. L. J. Bloemendal, Sam J. Moons, Jurriaan J. A. Heming, Mohamed Chayoua, Olaf Niesink, Jan C. M. van Hest, Thomas J. Boltje, Floris P. J. T. Rutjes
Pubblicato in: Advanced Synthesis & Catalysis, 2019, ISSN 1615-4150
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.201900146

Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs

Autori: Sam J Moons, Gosse J Adema, Max TGM Derks, Thomas J Boltje, Christian Büll
Pubblicato in: Glycobiology, 2019, ISSN 1460-2423
Editore: oxford academic
DOI: 10.1093/glycob/cwz026

Direct Experimental Characterization of Glycosyl Cations by Infrared Ion Spectroscopy

Autori: Hidde Elferink, Marion E. Severijnen, Jonathan Martens, Rens A. Mensink, Giel Berden, Jos Oomens, Floris P. J. T. Rutjes, Anouk M. Rijs, Thomas J. Boltje
Pubblicato in: Journal of the American Chemical Society, Numero 140/19, 2018, Pagina/e 6034-6038, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.8b01236

Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids

Autori: Torben Heise, Johan F. A. Pijnenborg, Christian Büll, Niek van Hilten, Esther D. Kers-Rebel, Natasja Balneger, Hidde Elferink, Gosse J. Adema, Thomas J. Boltje
Pubblicato in: Journal of Medicinal Chemistry, Numero 62/2, 2019, Pagina/e 1014-1021, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.8b01757

α-Selective Glycosylation with β-Glycosyl Sulfonium Ions Prepared via Intramolecular Alkylation

Autori: Sam J. Moons, Rens A. Mensink, Jeroen P. J. Bruekers, Maurits L. A. Vercammen, Laura M. Jansen, Thomas J. Boltje
Pubblicato in: The Journal of Organic Chemistry, Numero 84/7, 2019, Pagina/e 4486-4500, ISSN 0022-3263
Editore: American Chemical Society
DOI: 10.1021/acs.joc.9b00022

C-2 auxiliaries for stereoselective glycosylation based on common additive functional groups

Autori: Frank F. J. de Kleijne, Sam J. Moons, Paul B. White, Thomas J. Boltje
Pubblicato in: Organic & Biomolecular Chemistry, Numero 18/6, 2020, Pagina/e 1165-1184, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9ob02700a

Characterization of glycosyl dioxolenium ions and their role in glycosylation reactions

Autori: Thomas Hansen, Hidde Elferink, Jacob M. A. van Hengst, Kas J. Houthuijs, Wouter A. Remmerswaal, Alexandra Kromm, Giel Berden, Stefan van der Vorm, Anouk M. Rijs, Hermen S. Overkleeft, Dmitri V. Filippov, Floris P. J. T. Rutjes, Gijsbert A. van der Marel, Jonathan Martens, Jos Oomens, Jeroen D. C. Codée, Thomas J. Boltje
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-16362-x

Growth on Carbohydrates from Carbonaceous Meteorites Alters the Immunogenicity of Environment-Derived Bacterial Pathogens

Autori: Jorge Domínguez-Andrés, Marc Eleveld, Georgios Renieris, Thomas J. Boltje, Rob J. Mesman, Laura van Niftrik, Sam J. Moons, Petra Rettberg, Jos W.M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Huub J.M. Op den Camp, Marien I. de Jonge, Mihai G. Netea
Pubblicato in: Astrobiology, 2020, ISSN 1531-1074
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ast.2019.2173

GlycoCAP: A Cell-Free, Bacterial Glycosylation Platform for Building Clickable Azido-Sialoglycoproteins

Autori: Ariel Helms Thames, Sam J. Moons, Derek A. Wong, Thomas J. Boltje, Bruce S. Bochner, and Michael C. Jewett*
Pubblicato in: acs synthetic biology, 2023, ISSN 2049-3630
Editore: acs
DOI: 10.1021/acssynbio.3c00017

Structure-Activity Relationship of Metabolic Sialic Acid Inhibitors and Labeling Reagents

Autori: Sam J. Moons; Emiel Rossing; Mathilde A. C. H. Janssen; Torben Heise; Christian Büll; Gosse J. Adema; Thomas J. Boltje
Pubblicato in: VOLUME=17;STARTPAGE=590;ENDPAGE=597;ISSN=1554-8929;TITLE=Acs Chemical Biology, Numero 1, 2022, ISSN 2049-3630
Editore: acs
DOI: 10.1021/acschembio.1c00868

UV light-induced spatial loss of sialic acid capping using a photoactivatable sialyltransferase inhibitor

Autori: Sam J. Moons, Daniël L.A.H. Hornikx,‡b Mikkel K. M. Aasted,c Johan F.A. Pijnenborg,a Matteo Calzari,a Paul B. White,a Yoshiki Narimatsu,c Henrik Clausen,c Hans H. Wandall,c Thomas J. Boltje ORCID logo *a and Christian Büll ORCID logo *bc
Pubblicato in: rsc chemical biology, 2023, ISSN 2049-3630
Editore: rsc
DOI: 10.1039/d3cb00006k

Amadori rearrangement product as potential biomarkers for inborn errors of amino-acid metabolism

Autori: Rianne E. van Outersterp, Sam J. Moons, Udo F. H. Engelke, Herman Bentlage, Tessa M. A. Peters, Arno van Rooij, Marleen C. D. G. Huigen, Siebolt de Boer, Ed van der Heeft, Leo A. J. Kluijtmans, Clara D. M. van Karnebeek, Ron A. Wevers , Giel Berden, Jos Oomens, Thomas J. Boltje, Karlien L. M. Coene & Jonathan Martens
Pubblicato in: communications biology, 2021, ISSN 2049-3630
Editore: springer nature
DOI: 10.1038/s42003-021-01909-5

Sialic acids in gynaecological cancer development and progression: impact on diagnosis and treatment

Autori: Anna Y. Berghuis, Johan F. A. Pijnenborg, Thomas J. Boltje, Johanna M. A. Pijnenborg
Pubblicato in: molecular cancer biology, 2021, ISSN 2049-3630
Editore: wilet
DOI: 10.1002/ijc.33866